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Center for Cardiovascular Diagnostics & Prevention

The Center for Cardiovascular Diagnostics and Prevention is a joint effort of many specialized research centers.

The Center hosts a diverse range of research programs whose central theme is an emphasis on extending basic research observations into clinical studies. Areas of interest include:

Inflammation and inflammatory mediators of cardiovascular disease

  • Preventive cardiovascular medicine
  • Intestinal micro (gut) flora
  • Dysfunctional HDL
  • Genetic and molecular determinants of atherosclerotic plaque progression and vulnerability
  • Platelet activating factor (PAF) and involvement in atherothrombotic disease
  • Genetic determinants of cholesterol and fat absorption
  • Clinical utility of molecular markers of distinct oxidation pathways

Dr. Hazen, Chair of the Center for Cardiovascular Diagnostics and Prevention is currently focusing his research on:

  • Role of gut flora in cardiometabolic diseases
  • Role of myeloperoxidase in cardiovascular disease
  • HDL structure, function and dysfunction
  • Peroxidases and the origins of tissue injury in asthma
  • Molecular and genetic determinants of atherosclerotic plaque progression and vulnerability

Why use the Center for Cardiovascular Diagnostics and Prevention?

The Center has an outstanding level of accuracy and reliability. For example, our lipid assays are standardized with the Center for Disease Control and the Lab is accredited by the College of American Pathologists and C.L.I.A. Analyses for each study are run in ways to reduce variance and close attention is paid to each specimen. Costs are kept to minimum while ensuring the finest quality. Our test menu is constantly increasing; feel free to contact us for details.

Dr. Hazen

Stanley L. Hazen, MD, PhD
Chair, Center for Cardiovascular Diagnostics & Prevention
Vice Chair, Translational Research, Lerner Research Institute
Staff, Department of Cell Biology
Section Head, Preventive Cardiology & Rehabilitation, Department of Cardiovascular Medicine

Dr. Cho

Leslie Cho, MD, FACC
Staff, Department of Cardiovascular Medicine
Section Head, Preventive Cardiology & Rehabilitation, Department of Cardiovascular Medicine Medical Director, Preventive Cardiology Clinic
Director, Women's Center for Cardiovascular Medicine

Dr. DiDonato

Joseph DiDonato, PhD
Laboratory Director, Center for Cardiovascular Diagnostics & Prevention
Staff Scientist, Department of Cell Biology
Assistant Staff, Department of Cardiovascular Medicine

Dr. McIntyre

Thomas McIntyre, PhD
Staff, Department of Cell Biology
Staff, Department of Cardiovascular Medicine

Dr. Nicholls

Stephen J. Nicholls, MD, PhD, FACC
Clinical Director, Center for Cardiovascular Diagnostics & Prevention
Assistant Staff, Department of Cell Biology
Associate Staff, Department of Cardiovascular Medicine
Director, Atherosclerosis Imaging Core Lab

Dr. Sehayek

Ephraim Sehayek, MD
Assistant Staff, Department of Genomic Medicine Institute
Assistant Staff, Department of Cardiovascular Medicine

Dr. Tang

W.H. Wilson Tang, MD, FACC, FAHA
Staff, Department of Cell Biology
Staff, Department of Cardiovascular Medicine


The Preventive Research Lab

Dr. van Lente

Director - Frederick van Lente, PhD


Mass Spectrometry II Core

Prevention Research Laboratory (PRL)

Director - Frederick van Lente, PhD
Manager - Alan Pratt
Assistant Manager - Sarah Neale

The Preventive Research Laboratory (PRL) functions as a full-service core reference laboratory for clinical and diagnostic laboratory studies. PRL is College of American Pathologists (CAP) certified and Clinical Laboratory Improvement Act (CLIA) licensed, and serves as core facilities to the Cleveland Clinic Heart Center and the NIH-funded General Clinical Research Center. Many of the assays performed at PRL are CDC standardized. In addition to performing more 100 routine clinical diagnostic tests, PRL performs cutting-edge biochemical and genetic tests for the prediction, diagnosis and treatment of cardiovascular disease. Many novel diagnostic tests for cardiovascular disease developed within the Center are validated within PRL prior to implementation as high through-put assays. PRL also provides infrastructure with quality control oversight, and electronic storage/sample tracking procedures to effectively process blood, serum/plasma and DNA samples in support of clinical trials.

Molecular Diagnostics Laboratory

Director: Stanley Hazen, MD, PhD

Dr. Hazen’s lab within The Department of Cellular and Molecular Medicine is focused on finding the molecular and cellular mechanisms that cause diseases like heart disease and asthma, thus establishing a platform for treating and curing those diseases.

Mass Spectrometry II Core Laboratory

Director: Renliang Zhang MD, PhD

The Mass Spectrometry II Core Laboratory is designed to meet the growing needs of investigators for development of analytical methods for identification and quantification of biomarkers in plasma, tissue and other biological materials. The main focus of this core is quantitative analysis of small molecules in complex matrices and structural characterization of small compounds. The core offers the service for the investigators to develop analytical methods for:

  • Identification of novel bioactive compounds
  • Quantification of biomarkers in biological materials like plasma, urine and tissues

Contact Us

Prevention Research Lab
Sarah Neale MS neales@ccf.org
Mike Pepoy BS pepoym@ccf.org
Alan Pratt BS MT (ASCP) pratta@ccf.org
Phone: 216.444.5447 and 216.444.3136

Molecular Diagnostics Lab
Phone: 216.445.1900 (Lab)

Mass Spectrometry II Core Lab
Renliang Zhang MD, PhD Zhangr1@ccf.org

Reviewed: 02/14

Talk to a Nurse: Mon. - Fri., 8:30 a.m. - 4 p.m. (ET)

Call a Heart & Vascular Nurse locally 216.445.9288 or toll-free 866.289.6911.

Schedule an Appointment

Toll-free 800.659.7822

This information is provided by Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition.

© Copyright 2014 Cleveland Clinic. All rights reserved.

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