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Title A Physical Activity Intervention to Reduce Functional Health Disparities among Older Breast Cancer Survivors

IRB CASE2116

CC 011627C

Hospital Hillcrest, Main Campus

Disease Breast

To determine the effect of a refined and culturally-sensitive physical activity intervention on functional outcomes at 20 and 52 weeks among older BCa survivors who are within five years of treatment completion for stage I-III BCa.
To examine whether race and SES moderate the intervention effect on PA levels and functional outcomes at 20 and 52 weeks.
To examine the effect of the PA intervention on longitudinal changes in KAPs and PA levels, and the extent to which changes in these factors mediate intervention effect on functional outcomes. Participants will complete validated questionnaires to identify KAPs towards PA.
To determine the effect of the PA intervention on surrogate biomarkers associated with breast cancer prognosis and functional disability

Females with pathologically confirmed breast cancer
Stage I-III
Patients who have completed treatment but are within five years of treatment completion (primary surgery, chemotherapy or radiation therapy), whichever was received last. Hormonal therapy and targeted therapy are allowed
Age: 65 years and older
Race: African-Americans and Non-Hispanic Whites

Stage IV breast cancer
Patients with end-stage disease, severe dementia and/or life expectancy of less than one year
Inability to understand English as study instruments have not been validated in other languages
Inability to provide informed consent
High-risk patients (as defined by the American College of Sports Medicine risk-stratification schema using the ACSM/American Heart Association exercise pre-participation questionnaire) who do not receive clearance from cardiology, please see Table 1 and Appendix I
Other medical or psychological conditions that would make participation unsafe or inhibit our ability to test our primary hypothesis, e.g. Parkinson's disease, severe dementia.

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