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CBMT 1911   |   CC00043
(Adult/Pediatric) KIR Genotyping for Unrelated Donor (URD) Selection Prior to Hematopoietic Cell Transplantation (HCT) for AML: Selecting a Favorable KIR Donor

Blood & Marrow Transplant (BMT)
Leukemia, Acute Myeloid (AML)
Main Campus

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Primary Objective

  • To measure the impact of donor selection for KIR genotype in allogeneic URD HCT for AML on cumulative incidence of relapse

Secondary Objectives

  • To evaluate of the incidence of relapse free-survival and overall survival, as well as of endpoints not expected to be influenced by donor KIR selection including engraftment, GVHD and TRM. To determine the percentage of searches utilizing KIR genotyping to choose the best available KIR donor;
  • To measure the effect of the KIR genotyping process on the rate of optimal donor selection.

Inclusion Criteria

At or near the time a request for confirmatory typing is made for an unrelated donor (URD) for an AML patient enrolled on this study, CIBMTRstudy staff will mail the donor a buccal swab research kit. Donors who chose to participate in the study will be instructed to return a signed copy of the study consent form to the CIBMTR and mail the collected buccal swab sample to the KIR genotyping laboratory. Criteria for study participation are as follows:

  • Patient with acute myeloid leukemia (AML) undergoing screening for potential URD HCT
  • Potential URD undergoing screening to provide a HCT graft to a patient with acute myeloid leukemia (AML) at a participating institution
  • Provides written consent

Exclusion Criteria
Exclusion Criteria Not Available

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