We conduct clinical trials to advance new treatments and diagnostic approaches for patients with Alzheimer’s, Parkinson’s and Huntington’s disease, multiple sclerosis and frontotemporal dementia.
What are clinical trials and why are they conducted?
A clinical trial is a research process that is used to test new ways of treating disease.
There are many different types of clinical trials, from interventional (which include pill, infusion, device, diagnostic approach) to non-interventional (which include observations and follow-up without active treatment).
Clinical trials are the only way to test new drugs and advance treatment.
All drugs have to be tested in clinical trials to show they are safe and effective before they can be approved by the FDA to treat patients.
Why should I get involved with clinical trials?
Many people get involved because they want to help those suffering from a disease.
Others get involved to help themselves and because they will have access to the newest medication which is not available to the general public in addition to more comprehensive assessments.
The success of finding a new treatment depends on having enough patients to participate.
Your involvement is the key to finding cures and preventing the onset of brain diseases.
How do I participate?
Learn more about current trials at Cleveland Clinic Lou Ruvo Center for Brain Health:
Call: 702.685.7073
Email: brainhealth@ccf.org
You could do something today to make a difference for your family and your community. At your next visit, ask you doctor if clinical trials are right for you.
Current Clinical Trials
| Study Name |
Description |
Treatment |
| Avanir Study |
New drug to treat agitation in Alzheimer’s patients.
Age: 50-90
Duration: 10 weeks (8 clinic visits)
Study Tests: ECG, Memory and function tests
|
Oral Tablets Daily |
| AVID-B04 |
Parkinson's Disease.
Age: 40 or older
Duration: 18 months (3 clinic visits; 3 telehone checks)
Study Tests: MRI and PET tests
|
N/A |
| ASSESS |
Relapsing Remitting MS.
Age: 18-65
Duration: 12 or 15 months (daily study visits)
Study Tests: MRI and ECG tests
|
Oral Tablets Daily |
| B.E.A.T. AD |
Test an approved cancer drug in treating Alzheimer’s patients.
Age: 50-90
Duration: 10 weeks (7 clinic visits)
Study Tests: MRI, PET Scan, Blood test, Memory and function tests
|
Oral Tablets Daily |
| Neuronix |
For mild to moderate Alzheimer's disease.
Age: 60-90
Duration: 6 weeks (5 days a week)
Study Tests: MRI and ECG
|
Device |
| F-AV-45 |
Mild Impairment and Dementia.
Age: 50-90
Duration: 12 months (7 study visits)
Study Tests: PET
|
Intravenous |
| Nourish AD |
Mild to moderate Alzheimer's disease.
Age: 66 & older
Duration: 26 weeks (8 study visits)
Study Tests: ECG
|
Oral Tablets Daily |
| Teva |
Parkinson's Disease.
Age: 45-75
Duration: 24 weeks (once daily)
Study Tests: N/A
|
Oral Tablets Daily |
| BAF MS |
Secondary Progressiev Multiple Sclerosis.
Age: 18-60
Duration: 24-42 months depending on accural
Study Tests: MRI and ECG
|
Oral Tablets Daily |
Stay tuned for more information on upcoming clinical trials: the NICE Study and the Prevention Study.
For more information on how to get involved, please contact:
Samuel J. Hickson
Research Assistant/Recruitment Specialist
702.685.7073
brainhealth@ccf.org
Although tremendous progress has been made in the past 2 decades, no cure or treatment that slows or stops the deterioration caused by Alzheimer's disease has been found. That's why research continues to be critically important.
The FDA requires that all drugs be investigated in clinical trials to show they are safe and effective before they can be approved to treat patients.
Cleveland Clinic Lou Ruvo Center for Brain Health is one of the leading sites in the country conducting advanced clinical trial and translational research. The center is at the forefront of developing new treatment and diagnostic approaches for patients with cognitive disorders.
We conduct clinical trials sponsored by pharmaceutical, biotechnological, device and diagnostic assessment companies. We support research activities funded by government grants, private foundation and other philanthropic sources. We provide a wide range of drug development services.
With our innovative clinical trial consortium, Cleveland Clinic Lou Ruvo Center for Brain Health is revolutionizing the clinical trial process. Under the visionary leadership of Jeffrey L. Cummings, MD, ScD, a world renowned AD expert, and Kate Zhong, MD, a geriatric psychiatrist and pharmacologist, the consortium is committed to advancing research and providing new treatments to our patients suffering from neurodegenerative disorders. Trial sites are located in Las Vegas, Nevada; Cleveland, Ohio (main campus); Lakewood, Ohio and Weston, Florida.
Using one confidential disclosure agreement (CDA), one institutional review board (IRB), one budget, one contract, one electronic medical record (EMR) and one standard operational procedure (SOP), the consortium is united under a highly centralized system. The ONE model facilitates exemplary trial conduct by providing large patient volume, streamlined operations, rapid start up, speedy enrollment, high retention and quality data.
For more information, please contact:
Samuel J. Hickson
Research Assistant/Recruitment Specialist
702.685.7073 or brainhealth@ccf.org
Together, we will Keep Memory Alive for many years and generations to come.