Research

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George Hoppe, Ph.D.

Hoppe Publications 1994-2006

Papers
  1. Hoppe G, O'Neil J, Hoff HF. Inactivation of lysosomal proteases by oxidized LDL is partially responsible for its poor degradation by mouse peritoneal macrophages. J. Clin. Invest. 94:1506-1512, 1994.
  2. Smejkal G, Hoppe G, Hoff HF. Filipin as a fluorescent probe of lipoprotein-derived sterols on thin layer chromatograms. Anal Biochem 239:115-117, 1996.
  3. Hoppe G, Subbanagounder G, O'Neil J, Salomon RG, Hoff HF. Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid. Biochem. Biophys. Acta 1344:1-5, 1997.
  4. O'Neil J, Hoppe G, Sayre LM, Hoff HF. Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme. Free Radical Biol Med 23:215-225, 1997.
  5. Hoppe G, Ravandi A, Herrera D, Kuksis A, and Hoff HF. Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions. J. Lipid Res. 38:1347-1360, 1997.
  6. Hoppe G, O'Neil J, Sayre LM, Hoff HF. Non-conventional modification of low density lipoproteins: Chemical models for macrophage recognition of oxidized LDL. Biochem. Biophys. Acta 1362:103-108, 1997.
  7. Podrez EA, Hoppe G, O'Neil J, Sayre LM, Sheibani N, Hoff HF. Macrophage Receptors Responsible for Distinct Recognition of LDL Containing Pyrrole or Pyridinium Adducts: Models of Oxidized LDL. J. Lipid Res. 41:1455-1463, 2000.
  8. Hoppe G, Marmorstein AD, Pennock EA, and Hoff HF. Oxidized low density lipoprotein-induced inhibition of processing of photoreceptor outer segments by RPE. Invest Ophthalmol Vis Sci. 42:2714-2720, 2001.
  9. Podrez EA*, Hoppe G*, O'Neil J, and Hoff HF. Phospholipids in oxidized LDL not adducted to apo B are recognized by the CD36 scavenger receptor. Free Radical Biol Med 34:356-364, 2003. *Equal contribution.
  10. Chai Y-C, Hoppe G, and Sears JE. Reversal of protein S-glutathiolation by glutaredoxin in the retinal pigment epithelium. Exp Eye Res 76:155-159, 2003.
  11. Hoff HF, O'Neil J, Wu Z, Hoppe G, and Salomon RG. Phospholipid hydroxyalkenals: Biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions. Arterioscler Thromb Vasc Biol 23: 275-282, 2003.
  12. O'Neil J, Hoppe G, and Hoff HF. Phospholipids in Oxidized LDL Perturb the Ability of Macrophages to Degrade Internalized Macromolecules and Reduce Intracellular Cathepsin B Activity. Atherosclerosis 169:215-224, 2003.
  13. Bakall B, Marmorstein LY, Hoppe G, Peachey NS, Wadelius C, and Marmorstein AD. Expression and localization of bestrophin during normal mouse development. Invest Ophthalmol Vis Sci 44:3622-3628, 2003.
  14. Hoppe G, Chai Y-C, and Sears JE. Endogenous Oxidoreductase Expression is Induced by Aminoglycosides. Arch Biochem Biophys 414:19-23, 2003.
  15. Hoppe G, O'Neil J, Hoff HF, and Sears J. Products of lipid peroxidation induce missorting of the principal lysosomal protease in retinal pigment epithelium. Biochem. Biophys. Acta 1689:33-41, 2004.
  16. Hoppe G, Chai Y-C, Crabb J, and Sears J. Protein S-Glutathionylation in Retinal Pigment Epithelium Converts Heat Shock Protein 70 to an Active Chaperone. Exp Eye Res 78:1085-1092, 2004.
  17. Ravandi A, Babaei S, Leung R, Monge JC, Hoppe G, Hoff HF, Kamido H, and Kuksis A. Phospholipids and Oxophospholipids in Atherosclerotic Plaques at Different Stages of Plaque Development. Lipids 39:97-109, 2004.
  18. Hoppe G, O'Neil J, Hoff HF, and Sears J. Accumulation of oxidized lipid-protein complexes alters phagosome maturation in retinal pigment epithelium. Cell Mol Life Sci 61:1664-1674, 2004.
  19. Sears J and Hoppe G. Triamcinolone Acetonide Destabilizes VEGF mRNA in Müller Cells Under Continuous Cobalt Stimulation. Invest Ophthalmol Vis Sci 46:4336-4341, 2005.
  20. Sun M, Finnemann SC, Febbraio M, Shan L, Annangudi SP, Podrez EA, Hoppe G, Darrow R, Organisciak DT, Salomon RG, Silverstein RL, Hazen SL. Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: A potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions. J Biol Chem 281: 4222-4230, 2006.
  21. Stanton JB, Goldberg AFX, Hoppe G, Marmorstein LY, Marmorstein AD. Hydrodynamic Properties of Porcine Bestrophin-1 in Triton X-100. Biochem. Biophys. Acta 1758: 241-247, 2006.
  22. Yokoyama T, Yamane K, Minamoto A, Mishima HK, Yamashita H, Hoppe G, and Sears J. Protein Expression Patterns of Cultured Human RPE Cells Under Hyperglycaemic Condition Investigated by Proteome Analysis. Exp Eye Res 83: 602-609 2006.
  23. Hoppe G, Talcott KE, Bhattacharya SK, Crabb JW, Sears J. Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1. Exp Cell Res 312:3526-3538, 2006.
  24. Ebrahem Q, Minamoto A, Hoppe G, Anand-Apte B, Sears J. Triamcinolone Acetonide Inhibits VEGF-Dependent Angiogenesis Downstream of the VEGF and IL-6 Receptor. Invest Ophthalmol Vis Sci 47: 4935-4941, 2006.
  25. Hoppe G, Rayborn ME, Sears J. Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation. J Comp Neurol (accepted)
  26. Marinic T, Krukovets I, Hoppe G, Stenina OI. Cell type-specific regulation of expression of a potent antiangiogenic and proatherogenic protein thrombospondin-1 by glucose. FASEB J (in review)
Chapters and Reviews
  1. Hoff HF, O'Neil J, Hoppe G. Processing of oxidized LDL in macrophages. In: Atherosclerosis X. Proceedings of the 10th International Symposium on Atherosclerosis, Montréal, 1994. (Edited by Woodford FP, Davignon J, and Sniderman A), pp. 442-446, Elsevier Science B.V., Amsterdam, 1995.
  2. Hoff HF, and Hoppe G. Structure of cholesterol-containing particles accumulating in atherosclerotic lesions and the mechanisms of their derivation. Current Opinion in Lipidology 6(5): 317-325, 1995.
  3. Hoppe G, Marmorstein LY, and Marmorstein AD. Localization and functional analysis of bestrophin. In: New Insights into Retinal Degenerative Diseases.(Edited by RE Anderson, MM LaVail, and JG Hollyfield), pp. 207-216, Kluwer Academic/Plenum Publishers, New York, NY, 2001.
Abstracts
  1. Hoppe G, O'Neil J, and Hoff HF. Inactivation of lysosomal proteases by oxidized LDL is partially responsible for its poor degradation by macrophages. 66th Scientific Sessions of the American Heart Association, Atlanta, 1993, Circulation 88: I-181, 1993.
  2. Hoff HF, O'Neil J, and Hoppe G. Processing and trafficing of oxidized LDL in macrophages. 10th International Symposium on Atherosclerosis, Montréal, 1994, Atherosclerosis 109: 174, 1994.
  3. Hoff HF, O'Neil J, and Hoppe G. Inactivation of cathepsin B by oxidized low density lipoproteins at low pH involves binding of 4-hydroxynonenal to the thiol at its active site. 67th Scientific Sessions of the American Heart Association, Dallas, 1994, Circulation 90: I-354, 1994.
  4. Hoppe G, and Hoff HF. Poor hydrolysis of oxidized cholesteryl esters in macrophages. 68th Scientific Sessions of the American Heart Association, Anaheim, 1995, Circulation 92: I-289, 1995.
  5. Hoppe G, O'Neil J, Sayre LM, and Hoff HF. Chemical Models for Macrophage Recognition of Oxidized LDL. 69th Scientific Sessions of the American Heart Association, New Orleans, 1996, Circulation 94: I-400, 1996.
  6. Hoff HF, Hoppe G, Podrez EA, O'Neil J, and Sayre LM. Non-conventional Modifications of LDL That Model Changes in Oxidized LDL Critical for Receptor Recognition. 11th International Symposium on Atherosclerosis, Paris, 1997, Atherosclerosis 134: 223, 1997.
  7. Podrez EA, Hoppe G, O'Neil J, Aamir R, Sayre LM, Hoff HF. Different Macrophage Receptors Are Responsible for the Recognition of LDL Containing Pyrrole or Pyridinium Adducts: Models of Oxidized LDL. 70th Scientific Sessions of the American Heart Association, Orlando, 1997, Circulation 96: I-105, 1997.
  8. Hoppe G, O'Neil J, Podrez EA, and Hoff HF. A Class of Readily Exchangeable Lipids in Oxidized LDL Capable of Inducing Cathepsin B Inactivation. 70th Scientific Sessions of the American Heart Association, Orlando, 1997, Circulation 96: I-167, 1997.
  9. Podrez EA, Hoppe G, O'Neil J, Sayre LM, and Hoff HF. Mechanism of Oxidized LDL Recognition by the Macrophage CD36 Receptor. Role of Pyridinium Adducts on Lysines. 71th Scientific Sessions of the American Heart Association, Dallas, 1998, Circulation 98: I-521, 1998.
  10. Hoff HF, Marmorstein AD, Pennock EA, and Hoppe G. RPE Cells Treated with Oxidized Lipids Deficiently Process Rod Outer Segments. ARVO Annual Meeting, Fort Lauderdale, 2000.
  11. Hoppe G, Pennock EA, Marmorstein AD, and Hoff HF. Oxidized Lipids Inhibit Processing of Photoreceptor Outer Segments by Retinal Pigment Epithelial Cells. 40th Annual Meeting of ASCB, San Francisco, 2000.
  12. Hoppe G, Marmorstein LY, Bakall B, Pennock EA, Kyle N, Wang X, Wadelius C, and Marmorstein AD. Identification and Characterization of a Mouse Homologue of Bestrophin. ARVO Annual Meeting, Fort Lauderdale, 2001.
  13. Chai Y-C, Hoppe G, Mieyal JJ, and Sears JE. Reduction of Dehydroascorbate May Depend on Glutaredoxin in Human Retinal Pigment Epithelium In Vitro. ARVO Annual Meeting, Fort Lauderdale, 2002.
  14. Hoppe G, Chai Y-C, Mieyal JJ, and Sears JE. Glutaredoxin Expression in Human Retinal Pigment Epithelial Cell Lines Inversely Correlates with the Levels of Protein Glutathiolation. ARVO Annual Meeting, Fort Lauderdale, 2002.
  15. Hoppe G, Chai Y-C, West K and Sears JE. Glutathione as a second messenger of oxidation: Hsc70 is a substrate of glutaredoxin-1. ARVO Annual Meeting, Fort Lauderdale, 2003.
  16. Sears JE, Chai Y-C, and Hoppe G. Endogenous Oxidoreductase Expression is Induced by Aminoglycosides. ARVO Annual Meeting, Fort Lauderdale, 2003.
  17. Hoppe G, O'Neil J, Hoff HF, and Sears J. Arrest of phagosome maturation by products of lipid peroxidation via inhibition of phosphoinositide 3-kinase recruitment. 43th Annual Meeting of ASCB, San Francisco, 2003.
  18. Sears J and Hoppe G. Glutaredoxin Reduces Chaperone Activity via Deglutathionylation of Hsc70. ARVO Annual Meeting, Fort Lauderdale, 2004.
  19. Minamoto A, Hoppe G, Talcott K, Tanimura H, and Sears J. Triamcinolone Acetonide Decreases IL-6 Induced VEGF Secretion from Human Cultured RPE Cells. ARVO Annual Meeting, Fort Lauderdale, 2004.
  20. Hoppe G, O'Neil J, Hoff HF, and Sears J. Accumulation of Oxidized Lipid-Protein Complexes in the RPE Impedes Phagosome Maturation by Blocking Recruitment of Phosphatidylinositol-3-Kinase. ARVO Annual Meeting, Fort Lauderdale, 2004.
  21. Hoppe G, Talcott KE, Bhattacharya SK, Crabb JW, and Sears J. Identification of High Mobility Group Protein B1, a DNA-Binding Structural Chromosomal Protein, as a Novel Substrate of RPE Glutaredoxin. ARVO Annual Meeting, Fort Lauderdale, 2005.
  22. Sears J and Hoppe G. Triamcinolone Acetonide Decreases HIF-1 Binding to Hypoxia Response Element in Cobalt Stimulated Mueller Cells. ARVO Annual Meeting, Fort Lauderdale, 2005.
  23. Yokoyama T, Yamane K, Minamoto A, Mishima HK, Yamashita H, Hoppe G, and Sears J. Protein Expression Patterns of Cultured Human RPE Cells Under Hyperglycaemic Condition Investigated by Proteome Analysis. ARVO Annual Meeting, Fort Lauderdale, 2005.
  24. Hoppe G, Talcott KE, Bhattacharya SK, Crabb JW, Sears J. Distinct Roles for Cysteines in the Structure and Nuclear Transport of the Chromatin Protein Hmgb1. 45th Annual Meeting of ASCB, San Francisco, 2005.
  25. Sears JE, Ebrahem Q, Minamoto A, Hoppe G, B.Anand-Apte. IL-6 Induced Angiogenesis is VEGF Dependent and Blocked by Triamcinolone Acetonide. ARVO Annual Meeting, Fort Lauderdale, 2006.
  26. Hoppe G, Rayborn ME, Sears J. Expression of Chromatin Protein HMGB1 in Photoreceptors Is Under Circadian Regulation. ARVO Annual Meeting, Fort Lauderdale, 2006.
  27. Shadrach KG, de la Motte CA, Drazba J, Hoppe G, Senanayake PD, Hollyfield JG. Monocyte Adhesion to Retinal Pigment Epithelium Cells. ARVO Annual Meeting, Fort Lauderdale, 2006.