Respiratory Institute Outcomes
Chronic Thromboembolic Pulmonary Hypertension
Chronic Thromboembolic Pulmonary Hypertension
Pulmonary hypertension due to unresolved pulmonary emboli that narrow pulmonary arteries, also known as chronic thromboembolic pulmonary hypertension (CTEPH), is a deadly disease that can be effectively treated with a complex surgical procedure called pulmonary thromboendarterectomy (PTE). Since 2011, Cleveland Clinic has a multidisciplinary team dedicated to the evaluation and treatment of CTEPH patients. The team includes clinicians specializing in pulmonary medicine, cardiothoracic surgery, interventional radiology, chest radiology, nuclear medicine, cardiovascular medicine, anesthesiology, and critical care medicine.
Cleveland Clinic also offers PTE surgery to carefully selected patients with normal resting pulmonary hemodynamics who are symptomatic from chronic thromboembolic disease (CTED) as evidenced by invasive cardiopulmonary exercise testing.¹ ²
Pulmonary Thromboendarterectomy Experience (N = 368)
2011 – 2023
PTE = pulmonary thromboendarterectomy
During the past 29 years, 453 PTE surgeries have been performed at Cleveland Clinic. Between 1995 and 2010, operative mortality (i.e., in-hospital deaths) was 11.6%. Between 2011 and 2023, surgical volume more than quadrupled and the operative mortality decreased to 2.2%, a rate comparable to or better than current published literature. ¹ ²
Balloon Pulmonary Angioplasty (BPA) Experience 2016 – 2023 (138 Patients and 574 Sessions)
2016 – 2023
For patients with inoperable CTEPH or residual pulmonary hypertension after PTE, medical therapy followed by balloon pulmonary angioplasty (BPA) has become the standard of care. Between 2016 and 2023 the team has treated 138 patients for a total of 574 BPA sessions.
BPA = balloon pulmonary angioplasty, PTE = pulmonary thromboendarterectomy
With more than 50 PTE surgeries per year and more than 100 BPA sessions per year, the Cleveland Clinic multidisciplinary CTEPH program meets the volumes suggested by the guidelines for an expert CTEPH center. ³
References
- Jenkins DP, Tsui SS, Taghavi J, Kaul P, Ali J, Ng C. Pulmonary thromboendarterectomy-the Royal Papworth experience. Ann Cardiothorac Surg. 2022 Mar;11(2):128-132.
- de Perrot M, McRae K, Donahoe L, Abdelnour-Berchtold E, Thenganatt J, Granton J; Canadian CTEPH Working Group. Pulmonary endarterectomy in severe chronic thromboembolic pulmonary hypertension: the Toronto experience. Ann Cardiothorac Surg. 2022 Mar;11(2):133-1423.
- Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, Ferreira DS, Ghofrani HA, Giannakoulas G, Kiely DG, Mayer E, Meszaros G, Nagavci B, Olsson KM, Pepke-Zaba J, Quint JK, Rådegran G, Simonneau G, Sitbon O, Tonia T, Toshner M, Vachiery JL, Vonk Noordegraaf A, Delcroix M, Rosenkranz S; ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023 Jan 6;61(1):2200879