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Innovations Timeline

Since its founding, Cleveland Clinic has been home to major medical breakthroughs in medicine.

  • Isolation of serotonin, a key factor in hypertension (1940s)
  • Development of “no-touch” colorectal surgery (1950s)
  • First coronary angiography (1958)
  • Development and refinement of coronary bypass surgery (1967)
  • First minimally invasive aortic heart valve surgery (1996)
  • First successful larynx transplant (1998)
  • Discovery of first gene linked to juvenile macular degeneration (2000)
  • Discovery of first gene linked to coronary artery disease (2003)
  • Pioneering success in deep brain stimulation for psychiatric disorders and minimally conscious state (2006)
  • First kidney surgery performed through patient’s navel (2007)
  • Nation’s first near-total face transplant (2008)

In 2009, Cleveland Clinic continued to make headlines, furthering innovations in the following areas:

  • World’s first heart/liver transplant in patient with total artificial heart
  • Heart and Vascular Institute performs the largest number of Thoracic Aorta Surgeries in the world and sets a new record in both cardiac and thoracic surgery
  • World’s first completely transvaginal nephrectomy
  • World’s first single port gynecologic laparoendoscopic robotic procedure
  • World’s first single-port total proctocolectomy with ileal J-pouch
  • First treatment of Desmoid Tumors with radiofrequency ablation
  • World’s first use of ultrasound for continuous tap catheter insertion for kidney transplant
  • Ohio’s first robotic whipple procedure