Research & Publications †
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Dr. Southern is an Associate Staff Physician at the Respiratory Institute and holds a secondary appointment in the Lerner Research Institute Department of Pathobiology, where his research focus is Idiopathic Pulmonary Fibrosis (IPF). In the laboratory of Dr. Mitchell Olman, Dr. Southern helped develop a novel tissue-based assay to explore how fibroblasts and myofibroblasts (the scar-producing cells in IPF) interact with lung tissue matrix to propagate fibrosis. Using this method he has identified that, through activation of a motor protein called myosin II, normal lung tissue signals fibroblasts to migrate, while fibrotic lung tissue induces myofibroblast differentiation. His current research involves further exploration of the myosin II pathway to identify novel targets to stop the fibrotic process in patients with IPF. In addition, Dr. Southern conducts an outpatient clinic where he treats patients with all forms of interstitial lung disease and sarcoidosis. He serves as a co-investigator on a number of clinical trials for patients with IPF. He also supervises trainees in the Pulmonary Fellow Interstitial Lung Disease Clinic and on the inpatient pulmonary consult service.
Since joining the staff of the Cleveland Clinic in 2012, Dr.Southern has been invited to present his research findings at the American Thoracic Society International Conference, the Keystone Symposium on Fibrosis,and The Society for Clinical Research/Midwestern Section American Federation for Medical Research (CSCR/MWAFMR). He has received a funding award from the Research Program Committee at the Cleveland Clinic. He has served on the Intermune Advisory Board, and reviews manuscripts for the American Journal of Respiratory and Critical Care Medicine and the Journal of Biological Chemistry. Additionally, he serves as a volunteer physician at the Free Clinic and with MedWorks USA in Cleveland, OH.
Idiopathic Pulmonary Fibrosis, Interstitial Lung Diseases, Sarcoidosis
American Thoracic Society, American Society for Matrix Biology, American Association for the Advancement of Science
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As of 2/17/2015, Dr. Southern has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.
Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias. * Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.