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Frederick Heupler, Jr., MD


Frederick Heupler, Jr., MD
Department: Cardiovascular Medicine
Location: Cleveland Clinic Main Campus
Mail Code J2-3
9500 Euclid Avenue
Cleveland, OH 44195
Frederick Heupler, Jr., MD
Department: Heart and Vascular Institute
Director, Diagnostic Section, Cardiac Catheterization Laboratory
Location: Cleveland Clinic Main Campus
Mail Code J2-3
9500 Euclid Avenue
Cleveland, OH 44195
Type of Doctor:
Adults Only

Biographical Sketch

Frederick A. Heupler, Jr., MD, is a staff cardiologist in the Robert and Suzanne Tomsich Department of Cardiovascular Medicine at the Sydell and Arnold Miller Family Heart & Vascular Institute at Cleveland Clinic. Dr. Heupler is Director of the Diagnostic Section in the Sones Cardiac Catheterization Laboratory and specializes in cardiac catheterization, coronary artery disease, coronary spasm syndrome, cardiovascular PACS, and catheterization lab image quality analysis. He also leads efforts in quality improvement in the cardiac catheterization laboratory, digital-imaging technology in the cardiac catheterization laboratory, and surveys of cardiovascular and cardiac catheterization services in healthcare institutions. He pioneered the ergonovine test for coronary artery spasm, and he has written extensively on this subject. He is board-certified in internal medicine and cardiovascular disease.

Dr. Heupler is a Fellow of the American College of Cardiology, the Council on Clinical Cardiology of the American Heart Association, the American College of Chest Physicians, the American College of Physicians and the Society for Cardiac Angiography and Interventions. A member of the Ohio State Medical Association and the American Medical Association, he has served as Chairman of the Laboratory Performance Standards Committee of the Society for Cardiac Angiography and Interventions.

A graduate of the University of Pennsylvania School of Medicine in Philadelphia, Dr. Heupler completed his internship at the Hospital of the University of Pennsylvania and did both his residency and fellowship at Cleveland Clinic.

Education & Fellowships

Fellowship - Cleveland Clinic
Cardiovascular Disease
Cleveland, OH USA
Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA
Internship - Hospital of the University of Pennsylvania
Philadelphia, PA USA
Medical School - University of Pennsylvania School of Medicine
Philadelphia, PA USA
Undergraduate - Saint Vincent College
Latrobe, PA USA


  • Internal Medicine- Cardiovascular Disease
  • Internal Medicine

Specialty Interests

Coronary Artery Disease, Coronary Spasm Syndrome, Cardiac Catheterization, Valvular Heart Disease, Constrictive Pericarditis, Cath Lab Hemodynamics, Cath Lab Angiographic Equipment, Cath Lab Radiation Safety, Cardiovascular PACS.

Awards & Honors

"Top Docs", Cleveland Magazine, March, 2007 and March, 2006


  • Fellow, American College of Cardiology
  • Fellow, American Heart Association, Council on Clinical Cardiology
  • Fellow, American College of Physicians
  • Ohio State Medical Association
  • American Medical Association

Treatment & Services

Industry Relationships

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As of 5/23/2016, Dr. Heupler, Jr. has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English

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