Mark Luciano, MD, PhD


Mark Luciano, MD, PhD

Appointed: 1993

4.7 out of 5
156 Patient Satisfaction Ratings 10 Comments
Mark Luciano, MD, PhD
Department: Neurological Surgery
Section Head
Location: Cleveland Clinic Main Campus
Mail Code S60
9500 Euclid Avenue
Cleveland, OH 44195
Mark Luciano, MD, PhD
Department: Pediatric Surgery
Location: Cleveland Clinic Main Campus
Mail Code S60
9500 Euclid Avenue
Cleveland, OH 44195
Mark Luciano, MD, PhD
Department: Biomedical Engineering
Location: Cleveland Clinic Main Campus
Mail Code S60
9500 Euclid Avenue
Cleveland, OH 44195
Type of Doctor:
Both Adults and Children & Adolescents

Biographical Sketch

Mark G. Luciano, MD, PhD, FACS, came to the Cleveland Clinic Department of Neurosurgery in 1993 after training in general neurosurgery at the University of Pennsylvania and in pediatric neurosurgery at Harvard’s Boston Children’s Hospital. In addition, he was trained in research through a PhD from Tulane University and a fellowship at the National Institutes of Health. At Cleveland Clinic, he also holds adjunct positions in neuroscience research and in biomedical engineering.

Dr. Luciano is board-certified in general neurosurgery and in pediatric neurosurgery. He is Head of Congenital and Pediatric Neurosurgery and Co-Director of the Pediatric Neurology Center at Cleveland Clinic. His patients are children and adults with neurological congenital anomalies, hydrocephalus, cerebral cysts, tumors, craniofacial anomalies, tethered cord, Chiari malformation and cerebral palsy. As part of his section, Dr. Luciano also directs the Neuroendoscopy and CSF Disorders program. He is known nationally and internationally for his clinical activity, research and educational work in neuroendoscopy, a form of minimally invasive neurosurgery. Children and adults are referred who are in need of endoscopic procedures, such as those with ventricular tumors and cysts. Dr. Luciano has directed Cleveland-area, national and international courses in neuroendoscopy and has developed new techniques in minimally invasive neurosurgery.

Dr. Luciano is recognized as an international leader in hydrocephalus. His NIH-funded experimental research has centered on the brain’s adaptation to the chronic compression and hypoxia of hydrocephalus and on the dynamic relationship between the CSF and vascular systems. Dr. Luciano is an Adjunct Faculty member for Kent State and Cleveland State Universities and is training PhD graduate students in both engineering and neuroscience. His experimental work also has led to his invention and development of a novel device to increase cerebral blood flow.

At Cleveland Clinic, Dr. Luciano initiated the first multidisciplinary clinic in the country to diagnose and treat NPH, an increasingly recognized reversible form of imbalance and dementia. The “Aging Brain Clinic” or NPH Screening Clinic (Normal Pressure Hydrocephalus Screening Clinic) triages elderly patients with problems in balance and cognition. This clinic is a national role model for NPH diagnosis and treatment. As a result of his recognized leadership in hydrocephalus, Dr. Luciano has been on the National Hydrocephalus Association advisory board and has appeared in the local and national press and television including the Wall Street Journal, Good Morning America, and the Today Show.

In addition to national publications, peer-review and editorial activity, Dr. Luciano is an internationally invited speaker in neuroendoscopy, hydrocephalus and pediatric neurosurgery. He was the “Brahm Prakash Memorial Orator” in New Dehli, India, and has been invited as visiting professor and speaker in India, China, Egypt and Europe. He has initiated an international cooperation between Cleveland Clinic and Peking Union Medical Center in Beijing, China, for education in neuroendoscopy. In addition, he has served as host and thesis mentor for international MD research fellows from Egypt and Sweden.

Professional Highlights

  • Head, Pediatric & Congenital Neurosurgery
  • Staff, Joint Appointment, Division of Pediatrics, Cleveland Clinic Foundation
  •  Director, CSF Physiological Laboratory, Cleveland Clinic Foundation
  • Co-Director, Congress of Neurological Surgery Neuroendoscopy Course, 2005-2008
  • Visiting Professor, Peking Union Medical Center, China, 2006-2009
  • Keynote Lectureship Japan Society of Pediatric Neurosurgery, 2006-2011
  • NIH Grant Review Committee, Neurological Medical Devices 2010-2011
  • Founder and chair of Scientific Advisory Board for CSF Therapeutics, Inc

Education & Fellowships

Fellowship - Children's Hospital of Boston
Pediatric Neurosurgery-Clinica
Boston, MA USA
Residency - Hospital of the University of Pennsylvania
Philadelphia, PA USA
Fellowship - National Institutes of Health
Surg Neuro Research
Bethesda, MD USA
Internship - Loyola University Medical Center
General Surgery
Maywood, IL USA
Medical School - University of Chicago Pritzker School of Medicine
Chicago, IL USA
Undergraduate - University of Rochester
Rochester, NY USA


  • Neurological Surgery

Specialty Interests

Craniofacial, hydrocephalus, neuroendoscopy, neuro-oncology, pediatric neurosurgery, spasticity

Awards & Honors

  • Chair, Scientific Advisory Board, CSF Therapeutics, Inc.
  • Best Physicians, Northeast Ohio magazine
  • NIH R01-funded laboratory research
  • Visiting Professor, Peking Union Medical Center, China, 2006-2009
  • Best Doctors’, National Listing 2009-2014

Additional Training

  • Fellowship, Surgical Neurology Branch, National Institutes of Health, 1988-1990
  • State of Ohio Licensure #35-065678
  • Gamma Knife Certification
  • BCLS, ACLS, PALS Certified
  • American Board of Neurological Surgery
  • Bureau for Children with Medical Handicaps
  • American Board of Pediatric Neurosurgery

Innovations & Patents

  • Minimally invasive, laparoscopic shunt placement used to place CSF shunts with easier recovery and reduced risk
  • Minimally invasive Chiari decompression, with reduced incision length and depth for effective decompression and faster recovery time
  • Principle inventor and developer of patented "Cadence" device for increasing cerebral blood flow.  Now in laboratory development stage.


  • American Association of Neurological Surgeons
  • Congress of Neurological Surgeons
  • American Society of Pediatric Neurosurgeons
  • American College of Surgeons
  • Society for Research in Hydrocephalus and Spina Bifida

Treatment & Services

  • Brain Biopsy
  • Brain Tumor Surgery
  • Cervical Spine Surgery
  • Chiari Malformation Surgery
  • Congenital Neurosurgery
  • Craniotomy
  • Craniotomy For Brain Avm
  • Department of Pediatric Neurology & Neurosurgery
  • Endoscopic Brain Tumor Surgery
  • Endoscopic Minimally Invasive Neurosurgery
  • Epilepsy Surgery
  • Evaluation of Back Pain
  • General Neurosurgery
  • Intrathecal Baclofen Pump
  • Lumbar Spine Surgery
  • Microsurgical and Minimally Invasive Techniques
  • Minimally Invasive Spine Surgery
  • Minimally Invasive Surgery
  • Neuroendoscopy
  • Neurological Surgery
  • Neuro-Oncology
  • Neurosurgery
  • Pediatric Neuroscience
  • Pediatric Neurosurgery
  • Pediatric Oncology Neurosurgery
  • Skull Base Surgery
  • Spinal Surgery
  • Spine Decompression
  • Stereotactic Brain Biopsy
  • Stereotactic Surgery
  • Surgery For Spinal Tumors
  • Vascular Neurosurgery

Specialty in Diseases and Conditions

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. The Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, the Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 8/11/2014, Dr. Luciano has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English

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