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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Spanish
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Cardiovascular Medicine
  • Cardiovascular Medicine Department
  • Debridement of Skin and Wound
  • Non-Invasive Diagnostic Testing
  • Non-invasive Testing for Vascular Disease
  • Pseudoaneurysm Injection
  • Sclerotherapy
  • Thrombolytic Therapy
  • Unna Boot Application
  • Vascular Medicine Section
View all 10 Treatment & Services +

Specialty in Diseases & Conditions

  • Abdominal Aortic Aneurysm
  • Adverse Effects Anticoagulants
  • Antiphospholipid Syndrome
  • Aorta Disease
  • Aortic Aneurysms
  • Aortic Occlusion (blockage)
  • Arteriosclerosis Obliterans
  • Atheroembolism
  • Atherosclerosis (vascular)
  • Axillo Subclavian Vein Thrombosis
  • Bleeding Disorders
  • Blood Clots
  • Cardiovascular Risk Prevention
  • Carotid Artery Disease
  • Cellulitis
  • Cerebrovascular Occlusive Disease
  • Chronic Venous Insufficiency (CVI)
  • Coumadin Skin Necrosis
  • Cystic Adventitial Disease
  • Deep Vein Thrombosis
  • Edema
  • Erythema Ab Igne
  • Erythromelalgia
  • External Iliac Artery Endofibrosis
  • Factor V Leiden
  • Fibromuscular Dysplasia (FMD)
  • Frostbite
  • Heparin-induced Thrombocytopenia
  • Hepatic Artery Aneurysm
  • Iliac Artery Occlusion (blockage)
  • Intestinal Ischemic Syndrome
  • Ischemic Digits (Upper Extremity)
  • Klippel-Trenaunay Syndrome (KTS)
  • Leg Circulation Problems
  • Lipedema
  • Lower Extremity Ulcers
  • Lupus Anticoagulant
  • Lymphedema
  • Marfan Syndrome
  • May-Thurner Syndrome (MTS)
  • Median Arcuate Ligament Syndrome
  • Peripheral Artery Disease
  • Popliteal Artery Aneurysms
  • Popliteal Artery Entrapment Syndrome
  • Post-Phlebitic (Thrombotic) Syndrome
  • Protein C and S Deficiencies
  • Prothrombin Gene Mutation
  • Pulmonary Embolism
  • Raynaud's Phenomenon
  • Renal Artery Aneurysm
  • Renovascular Hypertension
  • Restless Leg Syndrome
  • Splenic Artery Aneurysm
  • Stenosis - Spinal
  • Superior Vena Cava Syndrome
  • Swollen Leg
  • Takayasu's Arteritis
  • Thoracic Outlet Syndrome
  • Thromboangitis Obliterans
  • Ulnar Artery Aneurysm
  • Varicose Veins
  • Vascular Anomalies
  • Vascular Diseases
  • Venous Insufficiency
  • Venous Stasis Leg Ulcers
  • Visceral Artery Aneurysms
  • Visceral Ischemic Syndrome
View all 67 Specialties +


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About John Bartholomew, MD

John R. Bartholomew, MD, is Director of the Thrombosis Center and a staff physician in the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic. He has a joint appointment to the Department of Hematology/Oncology. Dr. Bartholomew is board-certified as a Diplomat of the American Board of Internal Medicine and the American Board of Vascular Medicine. He is a Professor of Medicine for the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

Specialty/Clinical interests: New oral anticoagulants, adverse effects of anticoagulants, heparin-induced thrombocytopenia, blood clots, hypercoagulable states (thrombophilia), deep vein thrombosis (DVT), pulmonary embolism, thrombosis in unusual locations, inferior vena cava filters, general vascular medicine, peripheral arterial disease, unusual vascular disorders including erythromelalgia, pernio, lymphedema and lipedema.

Number of Procedures Performed:  Throughout his career, Dr. Bartholomew has performed more than 20,000 sclerotherapy procedures for patients with varicose and spider veins.

Success Rates: The Section of Vascular Medicine at Cleveland Clinic is one of the most active Vascular Medicine programs in the United States. Our specialists treat patients with a wide variety of vascular problems, including all forms of arterial, venous, and lymphatic disorders, cardiovascular risk factor management, thrombotic disorders, hypercoagulable states and wound care. In addition, we have expertise on the use of the new oral anticoagulants. Cleveland Clinic has specialty clinics for patients with a number of disorders, including fibromuscular dysplasia, retrieval of Inferior vena cava filters, endovenous laser ablation (first nationally accredited academic practice), and lymphedema. Patients also benefit from programs designed as a result of the department’s close collaborations with Medical Genetics, Pulmonary Function lab and Physical Therapy. Success rates for specific procedures are available at

Education and Training: Dr. Bartholomew completed his undergraduate work at Central Michigan University, and received his medical degree from the Autonomous Universidad De Guadalajara, in Guadalajara, Jalisco, Mexico. He completed his internship and residency at Maryland General Hospital in Baltimore, where he was Chief Resident. Dr. Bartholomew was awarded a fellowship by the Johns Hopkins Hospital and appointed Senior Clinical Fellow in the Division of Hematology. While at Johns Hopkins, he received the William Bell Award for Patient Care.

Prior to joining the Cleveland Clinic in 1988, Dr. Bartholomew was the Assistant Director of Internal Medicine Education at St. Joseph Hospital at Michigan State University, where he was given the Instructor of the Year Award for the Family Practice Residency Program. He also served as Director of the Eastern Michigan Hemophilia Center.

Dr. Bartholomew is the Director of the Vascular Medicine Section’s anticoagulation clinic. In 2003, Dr. Bartholomew was part of the clinical faculty for the Joint Commission Resources, Inc., for the Joint Commission on Accreditation of Hospital Organizations (JCAHO). He has also been a member of the Deep Vein Thrombosis Steering Committee for the National Quality Forum, which sets the national standards for the care of patients with Deep Vein Thrombosis and Pulmonary Embolism. He currently serves as the Director of the Cleveland Clinic Health Systems efforts to prevent and treat deep vein thrombosis and pulmonary embolism. He has a joint clinic with Interventional Radiology to evaluate patients for retrieval of their inferior vena cava filters and is Co-Director of the Pulmonary Embolism Response Team.

Research, Publications and Speaking: Dr. Bartholomew has published numerous articles and abstracts in professional scientific journals, including the Annals of Internal Medicine, Journal of Thrombosis and Hemostasis, Journal of Thrombosis and Thrombolysis, Transfusion, Cardiovascular Surgery, Circulation, the Cleveland Clinic Journal of Medicine, Chest, Archives of Internal Medicine, American Journal of Cardiology, Journal of American College of Cardiology, Journal of Pediatrics, Vascular and Endovascular Surgery, and Vascular Medicine. His publications focus on topics related to smokeless tobacco and cardiovascular risk, peripheral artery disease, pulmonary embolism, and heparin-induced thrombocytopenia, and deep vein thrombosis, among others. He has written more than 45 chapters in medical textbooks related to atheromatous embolization, stasis leg ulcers, hypercoagulable states, heparin-induced thrombocytopenia, and peripheral arterial disease.

Dr. Bartholomew has spoken at many major national meetings, workshops, symposiums and conferences about the diagnosis and treatment of patients with deep vein and pulmonary embolism and peripheral arterial disease, and the diagnosis and management of patients with hypercoagulable states and heparin-induced thrombocytopenia, as well as patients with unusual vascular disorders and lymphedema and lipedema.

About Dr. Bartholomew: “I enjoy my field because many of the patients I treat have disorders that are not well known to other physicians. In that way, patients are extremely thankful that there are physicians that deal with these unusual and often complicated diseases. Many of our patients go from doctor to doctor before they find the right answer to their medical problems, and it is gratifying to let them know that someone understands what is wrong with them. In addition, I like the opportunity to use the newer anticoagulants to treat patients who have blood clots and to help advance the field of medicine related to those events.”

Leisure Activities: In his spare time, Dr. Bartholomew enjoys fishing, hiking, skiing, writing and reading.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Johns Hopkins Hospital
Baltimore, MD USA

Residency - Maryland General Hospital
Internal Medicine
Baltimore, MD USA

Internship - Maryland General Hospital
Fifth Pathway
Baltimore, MD USA

Medical Education - Universidad Autonoma De Guadalajara
Guadalajara, Jalisco, Mexico

Undergraduate - Central Michigan University
Mt. Pleasant, MI USA


  • Internal Medicine

Specialty Interests

New oral anticoagulants, adverse effects of anticoagulants, heparin-induced thrombocytopenia, blood clots, hypercoagulable states (thrombophilia), deep vein thrombosis (DVT), pulmonary embolism, thrombosis in unusual locations, inferior vena cava filters, general vascular medicine, peripheral arterial disease, unusual vascular disorders including erythromelalgia, pernio, lymphedema and lipedema

Awards & Honors

  • 2014 Regional Top Doctor, Castle Connolly
  • Cleveland’s Best Doctors, Cleveland Magazine
  • Teacher of the Year, Cleveland Clinic Department of Vascular Medicine
Research & Publications

Research & Publications

See publications for John Bartholomew, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/9/2020, Dr. Bartholomew has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

176 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

65 Patient Comments

Reviewed on May 11, 2021

I'm dr. Bartholomew patient for 15-16 years and my wish, that all doctors could be like him. He is an excellent, professional and I wish him to stay healthy and serve Cleveland Clinic patients for many many years ahead.

Reviewed on May 11, 2021

Dr. Bartholomew was the kindest doctor I've ever met. He was very knowledgeable about my condition as well.

Reviewed on May 7, 2021

He is a outstanding Doctor.

Reviewed on Apr 28, 2021

Dr Bartholomew is an excellent, very thorough, physician. I felt very confident in his care.

Reviewed on Apr 27, 2021

one of the best doctors I see

Reviewed on Apr 23, 2021

The Dr was excellent.

Reviewed on Apr 13, 2021

Dr. Bartholomew is an excellent diagnostician and, just as importantly, is a very caring individual. He offers time, a listening ear, asks the right questions, and is clear and precise about addressing any problem. He treats a patient with dignity. You leave his presence with a confidence about how to address your medical need.

Reviewed on Apr 13, 2021

coming to the Cleveland clinic what is my best experience with doctors and care not only me but you're also taking care of my wife we are so happy it's overwhelmingThank you so much it's like your people attack our problems to solve them I hopeOther people can see your kindness

Reviewed on Apr 9, 2021

A wonderful doctor

Reviewed on Apr 9, 2021

Dr. Bartholomew is very thorough and cares about you.

Reviewed on Apr 6, 2021

Dr. Bartholomew is always very informative, helpful, courtious, respectful, and thorough. He explains things that regular people wouldn't know. He took the time to show me my ct scan of the blood clots in my lungs, explaining things along the way. And he is a very friendly man. I wish we could fish together sometime.

Reviewed on Mar 10, 2021

I am so fortunate to have such a gifted clinician and specialist looking after my health as Dr. Bartholemew. I appreciate his thorough review of my case, his kind consideration of alternatives, and his wonderful manner in communicating challenging medical information in a way that makes it easy for me to understand and make decisions. What a blessing to have someone of his skill in vascular medicine.

Reviewed on Feb 26, 2021

he is a patient man. excellent provider

Reviewed on Feb 12, 2021

Exceptional! Allotted me time to discuss my concerns and questions! Totally professional! Experienced! Explained the medical problem in detail. Provides a bond between doctor and patient ultimately providing better care.

Reviewed on Feb 12, 2021

Totally satisfied with my doctor appointment!

Reviewed on Feb 12, 2021

ver good access and communications with Dr Bartholomew via MyChart

Reviewed on Feb 12, 2021

Dr Bartholomew is an outstanding care giver. Sadly he is taking part-time retirement.

Reviewed on Jan 20, 2021

doctor b is a very knowledgeable man and he is very thorough.

Reviewed on Jan 19, 2021

Great Doctor & Right Questions, Help Us Get To a Path To Get Answers.

Reviewed on Dec 22, 2020

excellent doctor with obvious thoroughness and complete dedication to making sure the correct decision is made by employing all my doctors together into a decision.

Reviewed on Dec 15, 2020

I have already recommended Dr. Bartholomew to a friend.

Reviewed on Dec 8, 2020

I was very impressed with the amount of time the doctor spent with me examining and explaining my condition.

Reviewed on Dec 2, 2020

Dr. B is one of the best doctors at the Cleveland Clinic.

Reviewed on Nov 24, 2020

I have alway had very good service when working with the Cleveland Clinic. I have been truly lucky to find a doctor who understands lip edema. I wish that the Cleveland Clinic would beef up the Vascular department with more doctors interested in this malady. Perhaps the Cleveland Clinic could become the leader in this area. It is an area that most doctors do not understand and we need more doctors like Dr. Bartholomew to address this misunderstood malady.

Reviewed on Nov 24, 2020

Dr. B is why I selected the Cleveland Clinic.

Reviewed on Nov 20, 2020

Very respectful and great vascular doctor. I wish I had found him sooner.

Reviewed on Nov 17, 2020

Having been in Corporate Management all my life I am a fairly honest grader. I believe it is the responsibility of the individual and their company to have a continuous focus on always improving customer appreciation. That is why there are 5 goods above. Dr. Bartholomew as you know is an outstanding Doctor. Very detailed which I like because I am an Engineer. I felt very comfortable with him and he is the one Doctor in my life that has enumerated most of my medical problems. Thanks for bringing him back.

Reviewed on Oct 2, 2020

the doctor was excellent!

Reviewed on Sep 28, 2020

I appreciate the ease and thoroughness in being abl to discuss my condition with Dr. Bartholomew..

Reviewed on Sep 28, 2020

Of course video contact is not as optimal as in person visit, but provides a valuable experience for me to stay in contact with my Cleveland Clinic provider.

Reviewed on Sep 28, 2020

Dr B is the definition of physician. He is amazing

Reviewed on Sep 21, 2020

I have the utmost confidence in Dr. Bartholomew. I would travel anywhere to continue treatment with him. He is a great communicator, concerned about my progress and positive in his comments and direction. He offered me treatment options and did not pigeon-hole me in one plan.

Reviewed on Sep 11, 2020

always a great experience with Dr Bartholamew

Reviewed on Sep 10, 2020

very pleased over all experience with doctor Bartholomew and office team.

Reviewed on Sep 8, 2020

Dr Bartholomew provides excellent personal care. Very thorough, listens and asks questions. Best Dr and best facility I have ever visited. Everyone I come in contact with is friendly, polite, on time and respectful.

Reviewed on Sep 2, 2020

Dr. Bartholomew is an excellent doctor . I would recommend him to anyone.

Reviewed on Sep 2, 2020

I could not have been happier with the appointment that I had with Dr. Bartholomew. I scheduled the appointment to address a number of issues including a pre-existing condition that I had been seen at the clinic for previously (my past physician had left the clinic). He spent time on all of the issues and provided a complete physical exam and conversation to address them. He was thorough in addressing and listening to my questions and concerns and provided needed tests and materials that assisted me in understanding all of the issues. Following the appointment, he followed up to make sure I understood the treatment, tests and further recommendations for the conditions we discussed. His kindness, professional manner and sense of humor made what can be a stressful situation, much more relaxing.

Reviewed on Aug 26, 2020

Dr. B. was very good and caring. he discovered blood clots in my wife's leg. started immediately treatment. He was very busy and was rushed but I think he did the best he could under the circumstances. He did not have time to address all my wife's issues in this visit.

Reviewed on Aug 26, 2020

Dr. Bartholomew was exceptionally kind, patient and took a lot of time with me. he and his staff are amazing.

Reviewed on Aug 26, 2020

Dr. Bartholomew is amazing!

Reviewed on Aug 26, 2020

Dr. Bartholomew and his team are just incredible. They are so kind and patient with me. Dr. Bartholomew takes his time with me, let's me ask as many questions as I need, and never rushes me. I know how busy he must be, and I am so impressed with the time and attention he provides. It is an exceptional level of care. I am also so impressed with how the entire department runs. Communication is prompt and clear, wait times are almost non-existent, and every person you encounter is respectful and kind. It makes such a difference especially when you are nervous/anxious for the appointment.

Reviewed on Aug 26, 2020

Please see previous response. I can't say enough good things about Dr. Bartholomew and his staff!

Reviewed on Aug 26, 2020

I had a great experience at Cleveland Clinic and with Dr. Bartholomew and his team. I would highly recommend to anyone.

Reviewed on Aug 12, 2020

I love that doctor Bartholomew is very open and thorough

Reviewed on Aug 5, 2020

Dr. Bartholomew and his Team are awesome!

Reviewed on Aug 3, 2020

we love Dr Barthalowmew and his staff and ALWAYS HAVE A VERY GREAT EXPERIENCE!

Reviewed on Aug 3, 2020

Dr. Bartholomew was very thorough in discussing options for my Reynaud's.

Reviewed on Jul 28, 2020

The office staff was very kind. Dr. Bartholomew did not make me feel rushed at all. He seemed to have a genuine concern for my current condition. He provided me with a folder of information that included education. very much appreciated. He was a very kind man with wonderful bed side manner!

Reviewed on Jul 27, 2020

Dr. Bartholomew was outstanding in all respects.

Reviewed on Jul 21, 2020

I live in Indianapolis and drive to Cleveland for my appointments. The doctor and staff are always very helpful in coordinating my tests and doctor's visits so I can complete everything the same day and early enough in the day should anything else arise such as lab work for any studies I participate in.

Reviewed on Jul 14, 2020

CC changing the doctor experience. much appreciated. gone are the waiting lines ...

Reviewed on Jul 14, 2020

dr bartholomew is retiring. his approach is worth emulating by his replacement

Reviewed on Jul 13, 2020

Dr. Bartholomew is hands down one of the best physicians I have ever had

Reviewed on Jul 1, 2020

I would recommend Dr. Bartholomew to anyone....kindest and most professional doctor ever!

Reviewed on Jul 1, 2020

my appointment with Dr. Bartholomew was wonderful and he is very knowledgeable with lymphedema and was very supportive in providing me with the proper information and did a very thorough exam. Also gave me information to educate myself to slow the growth of my condition.

Reviewed on Jun 29, 2020

Even if I have to wait weeks, Dr. Bartholomew is worth waiting for..

Reviewed on Jun 29, 2020

Dr. B is one of the best physicians at the Clinic. He is thorough and reviews our cases and knows our history. We have been with him for 16 years.

Reviewed on Jun 22, 2020

Dr B has always been a pleasure to work with

Reviewed on Jun 19, 2020

Dr. Bartholomew answered all of my questions completely, explained the purpose of tests and did a good exam of leg circulation.

Reviewed on Jun 18, 2020

Dr Bartholomew is one of the most patient centric clinicians I've ever known. He deals in reality with the most phenomenal level of patient care and concern.

Reviewed on Jun 15, 2020

I have most utmost respect and confidence in Dr. Bartholomew and the staff.

Reviewed on Jun 15, 2020

just a wonderful caring and through

Reviewed on Jun 9, 2020

I have always had good visits with Dr. Bartholomew. He is kind and caring. Also, I brought up a procedure that he said he hadn't heard of before, but while we were talking, he looked it up on the computer and remembered being at a seminar where it was discussed. He also said he would check with the surgeons to see if they performed it.

Reviewed on Jun 3, 2020

wonderful meeting Dr. Bartholomew. I had a great level of comfort discussing my medical conditions with him. Excellent professional that I have recommended to several friends. His demeanor made me feel very comfortable during my visit.

Reviewed on Jun 3, 2020

I live 35 minutes from Pittsburgh and yet it is my choice to seek treatment from physicians that provide a level of comfort.

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