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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Spanish
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Specialties & Treatments

Treatment & Services

  • Cardiovascular Medicine
  • Cardiovascular Medicine Department
  • Debridement of Skin and Wound
  • Non-Invasive Diagnostic Testing
  • Non-invasive Testing for Vascular Disease
  • Pseudoaneurysm Injection
  • Sclerotherapy
  • Thrombolytic Therapy
  • Unna Boot Application
  • Vascular Medicine Section
View all 10 Treatment & Services +

Specialty in Diseases & Conditions

  • Abdominal Aortic Aneurysm
  • Adverse Effects Anticoagulants
  • Antiphospholipid Syndrome
  • Aorta Disease
  • Aortic Aneurysms
  • Aortic Occlusion (blockage)
  • Arteriosclerosis Obliterans
  • Atheroembolism
  • Atherosclerosis (vascular)
  • Axillo Subclavian Vein Thrombosis
  • Bleeding Disorders
  • Blood Clots
  • Cardiovascular Risk Prevention
  • Carotid Artery Disease
  • Cellulitis
  • Cerebrovascular Occlusive Disease
  • Chronic Venous Insufficiency (CVI)
  • Coumadin Skin Necrosis
  • Cystic Adventitial Disease
  • Deep Vein Thrombosis
  • Edema
  • Erythema Ab Igne
  • Erythromelalgia
  • External Iliac Artery Endofibrosis
  • Factor V Leiden
  • Fibromuscular Dysplasia (FMD)
  • Frostbite
  • Heparin-induced Thrombocytopenia
  • Hepatic Artery Aneurysm
  • Iliac Artery Occlusion (blockage)
  • Intestinal Ischemic Syndrome
  • Ischemic Digits (Upper Extremity)
  • Klippel-Trenaunay Syndrome (KTS)
  • Leg Circulation Problems
  • Lipedema
  • Lower Extremity Ulcers
  • Lupus Anticoagulant
  • Lymphedema
  • Marfan Syndrome
  • May-Thurner Syndrome (MTS)
  • Median Arcuate Ligament Syndrome
  • Peripheral Artery Disease
  • Popliteal Artery Aneurysms
  • Popliteal Artery Entrapment Syndrome
  • Post-Phlebitic (Thrombotic) Syndrome
  • Protein C and S Deficiencies
  • Prothrombin Gene Mutation
  • Pulmonary Embolism
  • Raynaud's Phenomenon
  • Renal Artery Aneurysm
  • Renovascular Hypertension
  • Restless Leg Syndrome
  • Splenic Artery Aneurysm
  • Stenosis - Spinal
  • Superior Vena Cava Syndrome
  • Swollen Leg
  • Takayasu's Arteritis
  • Thoracic Outlet Syndrome
  • Thromboangitis Obliterans
  • Ulnar Artery Aneurysm
  • Varicose Veins
  • Vascular Anomalies
  • Vascular Diseases
  • Venous Insufficiency
  • Venous Stasis Leg Ulcers
  • Visceral Artery Aneurysms
  • Visceral Ischemic Syndrome
View all 67 Specialties +


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About John Bartholomew, MD

John R. Bartholomew, MD, is Director of the Thrombosis Center and a staff physician in the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic. He has a joint appointment to the Department of Hematology/Oncology. Dr. Bartholomew is board-certified as a Diplomat of the American Board of Internal Medicine and the American Board of Vascular Medicine. He is a Professor of Medicine for the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

Specialty/Clinical interests: New oral anticoagulants, adverse effects of anticoagulants, heparin-induced thrombocytopenia, blood clots, hypercoagulable states (thrombophilia), deep vein thrombosis (DVT), pulmonary embolism, thrombosis in unusual locations, inferior vena cava filters, general vascular medicine, peripheral arterial disease, unusual vascular disorders including erythromelalgia, pernio, lymphedema and lipedema.

Number of Procedures Performed:  Throughout his career, Dr. Bartholomew has performed more than 20,000 sclerotherapy procedures for patients with varicose and spider veins.

Success Rates: The Section of Vascular Medicine at Cleveland Clinic is one of the most active Vascular Medicine programs in the United States. Our specialists treat patients with a wide variety of vascular problems, including all forms of arterial, venous, and lymphatic disorders, cardiovascular risk factor management, thrombotic disorders, hypercoagulable states and wound care. In addition, we have expertise on the use of the new oral anticoagulants. Cleveland Clinic has specialty clinics for patients with a number of disorders, including fibromuscular dysplasia, retrieval of Inferior vena cava filters, endovenous laser ablation (first nationally accredited academic practice), and lymphedema. Patients also benefit from programs designed as a result of the department’s close collaborations with Medical Genetics, Pulmonary Function lab and Physical Therapy. Success rates for specific procedures are available at

Education and Training: Dr. Bartholomew completed his undergraduate work at Central Michigan University, and received his medical degree from the Autonomous Universidad De Guadalajara, in Guadalajara, Jalisco, Mexico. He completed his internship and residency at Maryland General Hospital in Baltimore, where he was Chief Resident. Dr. Bartholomew was awarded a fellowship by the Johns Hopkins Hospital and appointed Senior Clinical Fellow in the Division of Hematology. While at Johns Hopkins, he received the William Bell Award for Patient Care.

Prior to joining the Cleveland Clinic in 1988, Dr. Bartholomew was the Assistant Director of Internal Medicine Education at St. Joseph Hospital at Michigan State University, where he was given the Instructor of the Year Award for the Family Practice Residency Program. He also served as Director of the Eastern Michigan Hemophilia Center.

Dr. Bartholomew is the Director of the Vascular Medicine Section’s anticoagulation clinic. In 2003, Dr. Bartholomew was part of the clinical faculty for the Joint Commission Resources, Inc., for the Joint Commission on Accreditation of Hospital Organizations (JCAHO). He has also been a member of the Deep Vein Thrombosis Steering Committee for the National Quality Forum, which sets the national standards for the care of patients with Deep Vein Thrombosis and Pulmonary Embolism. He currently serves as the Director of the Cleveland Clinic Health Systems efforts to prevent and treat deep vein thrombosis and pulmonary embolism. He has a joint clinic with Interventional Radiology to evaluate patients for retrieval of their inferior vena cava filters and is Co-Director of the Pulmonary Embolism Response Team.

Research, Publications and Speaking: Dr. Bartholomew has published numerous articles and abstracts in professional scientific journals, including the Annals of Internal Medicine, Journal of Thrombosis and Hemostasis, Journal of Thrombosis and Thrombolysis, Transfusion, Cardiovascular Surgery, Circulation, the Cleveland Clinic Journal of Medicine, Chest, Archives of Internal Medicine, American Journal of Cardiology, Journal of American College of Cardiology, Journal of Pediatrics, Vascular and Endovascular Surgery, and Vascular Medicine. His publications focus on topics related to smokeless tobacco and cardiovascular risk, peripheral artery disease, pulmonary embolism, and heparin-induced thrombocytopenia, and deep vein thrombosis, among others. He has written more than 45 chapters in medical textbooks related to atheromatous embolization, stasis leg ulcers, hypercoagulable states, heparin-induced thrombocytopenia, and peripheral arterial disease.

Dr. Bartholomew has spoken at many major national meetings, workshops, symposiums and conferences about the diagnosis and treatment of patients with deep vein and pulmonary embolism and peripheral arterial disease, and the diagnosis and management of patients with hypercoagulable states and heparin-induced thrombocytopenia, as well as patients with unusual vascular disorders and lymphedema and lipedema.

About Dr. Bartholomew: “I enjoy my field because many of the patients I treat have disorders that are not well known to other physicians. In that way, patients are extremely thankful that there are physicians that deal with these unusual and often complicated diseases. Many of our patients go from doctor to doctor before they find the right answer to their medical problems, and it is gratifying to let them know that someone understands what is wrong with them. In addition, I like the opportunity to use the newer anticoagulants to treat patients who have blood clots and to help advance the field of medicine related to those events.”

Leisure Activities: In his spare time, Dr. Bartholomew enjoys fishing, hiking, skiing, writing and reading.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Johns Hopkins Hospital
Baltimore, MD USA

Residency - Maryland General Hospital
Internal Medicine
Baltimore, MD USA

Internship - Maryland General Hospital
Fifth Pathway
Baltimore, MD USA

Medical Education - Universidad Autonoma De Guadalajara
Guadalajara, Jalisco, Mexico

Undergraduate - Central Michigan University
Mt. Pleasant, MI USA


  • Internal Medicine

Specialty Interests

New oral anticoagulants, adverse effects of anticoagulants, heparin-induced thrombocytopenia, blood clots, hypercoagulable states (thrombophilia), deep vein thrombosis (DVT), pulmonary embolism, thrombosis in unusual locations, inferior vena cava filters, general vascular medicine, peripheral arterial disease, unusual vascular disorders including erythromelalgia, pernio, lymphedema and lipedema

Awards & Honors

  • 2014 Regional Top Doctor, Castle Connolly
  • Cleveland’s Best Doctors, Cleveland Magazine
  • Teacher of the Year, Cleveland Clinic Department of Vascular Medicine
Research & Publications

Research & Publications

See publications for John Bartholomew, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/9/2020, Dr. Bartholomew has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

104 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

37 Patient Comments

Reviewed on Dec 28, 2022

Dr Bartholomew is an amazing doctor he has always provided me with exceptional care .

Reviewed on Dec 14, 2022

The personnel at the clinic including doctors nurses and staff were very interested in helping me with my needs. Hoping we find a solution to my problem.

Reviewed on Nov 15, 2022

As always, Dr B was thorough. Professional & caring. One of the best.

Reviewed on Nov 15, 2022

Dr. B is very caring and very thorough. He knows my history and he checks my progress with my problems.

Reviewed on Oct 25, 2022

Always pleasant, concerned and respectful; I would recommend him to others. My wife and I both like him and respect him!

Reviewed on Oct 21, 2022

Dr. Bartholomew was WONDERFUL!!!! I was referred to him by a family friend with same condition as me. He made me feel heard, he was so thorough, cared and helpful. Gave me good advice and started a plan for my treatment. I am grateful to him because he is so skilled in his field and I needed his expertise. He showed compassion and I felt that he was definitely advocating for me. I had been waiting months for this appt. I felt so good leaving and some relief and it made my day, week, month. I am so grateful to be under his care.Thank you Dr. Bartholomew!!

Reviewed on Oct 4, 2022

Dr. Bartholomew is outstanding.

Reviewed on Sep 20, 2022

I dont think Dr. Bartholomew really understands eating disorders- which is true of most doctors. I dont think that the doctor really had a thorough understanding of my entire health picture and how that impacts ability to manage the condition for which I was seeking help. That is frequently a problem given the fractured nature of health care. I also have a complicated set of interacting problems. Many health care providers do not get the full picture. Given the interaction of my health care problems, it is getting harder for me to comply with all aspects of my treatment as well as I should. Weight loss is particularly hard for me, which I am sure Dr. Bartholomew hears often.

Reviewed on Sep 20, 2022

Doc was excellent

Reviewed on Aug 26, 2022

I owe Dr Bartholomew so mush, as he motivated me into a much needed exercise program, which has greatly improved my health level and how well I constantly feel.

Reviewed on Aug 26, 2022

I look forward to all visits with Dr. Bartholomew. He is a fabulous doctor.

Reviewed on Aug 16, 2022

Dr. Bartholomew explained and answered my concerns plus put to rest concerns that did not apply.

Reviewed on Aug 12, 2022

Doctor has always been attentive to my needs.

Reviewed on Aug 12, 2022

One of the most dedicated doctors I have ever seen.

Reviewed on Aug 12, 2022

If someone is lucky enough to have Dr. Bartholomew as a doctor I rate him aA+++!

Reviewed on Jul 20, 2022

Dr. Bartholomew has to be the kindest, friendliest doctor I have ever met! He is an asset to Cleveland Clinic and to mankind as a whole. If there was ever anyone meant to be a doctor, it is Dr. Bartholomew! He is truly a blessing on this earth!

Reviewed on Jul 15, 2022

Dr. Bartholomew is an outstanding doctor. He is caring and very thorough. One of the best that I have seen at CC

Reviewed on Jul 13, 2022

Dr. Barrhemew was wonderful, caring, informative and presented the first hope I've received regarding this disorder

Reviewed on Jun 21, 2022

One of the best providers I've seen. Very professional and thorough.

Reviewed on Jun 10, 2022

Although I was not able to get an appointment for some time, it was not necessarily with *Dr. Bartholomew. I was trying to get appointment with Vascular Medicine.

Reviewed on Jun 10, 2022

*Dr. Bartholomew was the last of several doctors trying to treat a rash on my foot for 2 years, while he appeared to rule out vascular problems, he gave me a prescription for an ointment which may help. Yet to see if it cures it.

Reviewed on Jun 8, 2022

Dr. Bartholomew is always great. He is very considerate, thorough, and knowledgeable about his patients' condition.

Reviewed on Jun 1, 2022

Dr Bartholomew was awesome!

Reviewed on May 31, 2022

Fabulous team working rith Dr.B.He is my favorite physician.

Reviewed on May 24, 2022

He is a wonderful doctor. Incredibly knowledgeable, detailed, diligent, kind. I really trust him and the care he provides.

Reviewed on May 11, 2022

Doctor Bartholomew was wonderful. He Listened , gave advice, has followed through asking other doctors about my condition , truly made me feel like he wants to help me with my Lipadema issues.

Reviewed on May 11, 2022

Just wish we had this kind of medical care here where we live in Evansville, Indiana! No wonder we've heard so many people give merit to Dr Bartholomew! We truly appreciate the time he spent with us! You can tell his dedication to helping people!!

Reviewed on May 10, 2022

Dr. Bartholomew deserves a 10, not a 5!

Reviewed on May 6, 2022

Dr. Bartholomew was wonderful

Reviewed on Apr 12, 2022

Dr. Barthalomew explains every clearly and in detail. The doctor calls my daughter with my updated medical concerns and treatment. Completely feel in the best of hands.

Reviewed on Apr 1, 2022

I find Dr Bartholomew is a great Doctor, He is very thorough and nice to deal with

Reviewed on Mar 29, 2022

Dr. Bartholemew is the best! His nurse Kathy is too!

Reviewed on Mar 29, 2022

Dr. Bartholomew is probably THE BEST doctor I've ever seen. He took his time asking so many questions and listening to my replies. Although I've researched a lot about Lipedema on my own, he's the first doctor I've seen that was so thorough and efficient. He gave me so much more information that I didn't even know. Plus he sent me home with a packet of excellent information that I can refer back to. I would highly recommend him and look forward to the next visit I have with him.

Reviewed on Mar 4, 2022

Doctor very good. Very thorough

Reviewed on Feb 23, 2022

Dr. Bartholomew was the kindest, most humble doctor I have ever met!

Reviewed on Feb 22, 2022

Dr. Bartholomew was my caregiver. He is an exceptional physician, able to answer and explain all questions the patient may have at a level he or she completely understands. No issues.

Reviewed on Jan 26, 2022

Just the greatest and caring doctor

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