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Department Epilepsy Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Clinical Trials
  • Early Epilepsy Surgery
  • Epilepsy Pharmacotherapy with Call Office
  • Epilepsy Surgery
  • Epilepsy Surgery And Video Eeg Evaluation
  • Epilepsy Surgery Evaluation
  • Epilepsy Surgery in Adolescents
  • Epilepsy Surgery In Children
  • Pediatric Neurology
  • Signal Analyses of Subdural Recordings
  • Specialized EEG with Stereotactic Depth Electrodes
  • Specialized EEG With Subdural Grids
  • Surgery In Brain Malformations
  • Vagal Nerve Stimulation
  • Video EEG Monitoring
View all 15 Treatment & Services +

Specialty in Diseases & Conditions

  • Autoimmune Epilepsy
  • Benign Focal Epilepsies and Variants
  • Brain Tumor-Related Epilepsy
  • Clinical Neurophysiology
  • Complex Partial Seizures
  • Cortical Brain Mapping
  • Developmental Disorders Of The Brain
  • Dravet and Doose Syndrome and other Myoclonic Epilepsies
  • Electroencephalogram (EEG)
  • Epilepsy
  • Epilepsy in Adolescents
  • Epilepsy in Children
  • Epilepsy in Infants
  • Epileptic Encephalopathies
  • First Seizure Assessment
  • Focal Cortical Dysplasia
  • Frontal Lobe Epilepsy
  • Genetic & Metabolic causes of Epilepsy
  • Hemispheric Epilepsy
  • Infantile Spasm
  • Intractable (Drug Resistant) Epilepsy
  • Ketogenic Diet
  • Landau–Kleffner Syndrome (LKS)
  • Lennox-Gastaut Syndrome
  • Lissencephaly
  • Malformations Of Cortical Development
  • Medically Refractory Status Epilepticus
  • Mitochondrial Causes of Epilepsy
  • Myoclonic Epilepsy
  • Neurodegenerative Diseases
  • Neurofibromatosis
  • Non-epileptic seizure disorder
  • Post-traumatic Epilepsy
  • Rasmussen Encephalitis
  • Refractory Epilepsy
  • Seizure Manifestations
  • Seizures
  • Seizures - Febrile
  • Seizures After Traumatic Brain Injury
  • Sleep and Epilepsy Issues
  • Status Epilepticus (continuous Seizures)
  • Stroke Causing Seizures
  • Sturge-Weber Syndrome
  • Temporal Lobe Epilepsy (TLE)
  • Tuberous Sclerosis Complex
  • West Syndrome
View all 46 Specialties +


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About Elaine Wyllie, MD

Dr. Elaine Wyllie is Professor of Neurology at the Cleveland Clinic Lerner College of Medicine and a world-renowned epilepsy specialist at Cleveland Clinic who provides treatment for children from around the world.   Her honors include the highly competitive Epilepsy Research Award from the American Epilepsy Society, the Jasper Award from the American Clinical Neurophysiology Society, and the Cleveland Clinic Award for Master Clinician.  She is editor of “Wyllie’s Treatment of Epilepsy”, the standard in the field through seven editions, and author of “The Cleveland Clinic Guide to Epilepsy”, an authoritative book for the lay public.

Dr. Wyllie has published over 250 reports on her scientific research.  Throughout her career she has championed offering early surgery to infants and children with uncontrolled seizures, to improve quality of life and maximize developmental potential. Her current research, expanding and redefining key aspects of the selection criteria for epilepsy surgery candidates, is influencing clinical practice at epilepsy centers throughout the world. She lectures extensively and has presented her research at over 500 scientific meetings and visiting professorships worldwide.  You may view the experience of two of her patients in the CNN-produced video Cleveland Clinic: A Culture of Breakthroughs.

Dr. Wyllie has mentored hundreds of epilepsy fellows, many of whom are now leaders of their own programs.  She is also committed to conversation with patients and families, and authors a regular blog on epilepsy for US News & World Report.  She enjoys a balanced life with her husband, Dr. Robert Wyllie, and now that their two sons are grown, their passionate hobby is ballroom dancing.  If you are interested to see another side of her life, you may view some of Dr. Wyllie’s dance videos at, and if you would like to hear an interview with Dr. Wyllie about her life in medicine and how dancing has influenced her work, visit Cleveland Clinic: Insights and Inspiration.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Epilepsy and Clinical Neurophysiology
Cleveland, OH USA

Residency - Cleveland Clinic
Pediatric Neurology
Cleveland, OH USA

Residency - Case Western Reserve University - University Hospitals of Cleveland
Cleveland, OH USA

Residency - Indiana University Medical Center
Indianapolis, IN USA

Medical Education - Indiana University School of Medicine
Indianapolis, IN USA

Professional Highlights

  • Professor, Cleveland Clinic Lerner College of Medicine with Case Western University.
  • Certified by the American Boards of Pediatrics and Psychiatry and Neurology, with Special Competencies in Pediatric Neurology and Epilepsy
  • Editor of the leading medical textbook in the field, Wyllie’s Treatment of Epilepsy, now in its sixth edition.
  • Author of The Cleveland Clinic Guide to Epilepsy, an authoritative book for the lay public.
  • A world renowned thought leader in epilepsy medicine who lectures widely and has published over 250 reports on her research in epilepsy in scientific journals.
  • Recipient of many honors and awards, including the prestigious Career Award for Outstanding Work in Epilepsy Research from the American Epilepsy Society.
  • An active clinician who cares for children with all forms of epilepsy and attracts personal referrals from physicians worldwide for consultation on the most challenging cases.
  • A champion for recognizing opportunities for offering early epilepsy surgery to infants and children with uncontrolled seizures, to reduce suffering and maximize developmental potential.


  • Pediatrics
  • Psychiatry and Neurology - Neurology with Special Qualifications in Child Neurology
  • Psychiatry and Neurology - Epilepsy
  • Neurology with Special Qualification in Child Neurology
  • - Pediatrics - General Cert
  • - Neurology with Special Qualifications in Child Neurology - G

Specialty Interests

Children with complex epilepsies, children with epilepsy and Sturge Weber Syndrome, children with first seizure, clinical drug trials, clinical neurophysiology, diagnostic video EEG for pediatric seizure disorders, EEG, Epilepsy, epilepsy and epilepsy surgery in children and adolescents, Epilepsy surgery and medical treatment of epilepsy in children, invasive EEG monitoring for pre-surgical evaluations, Pediatric Epilepsy, pediatric epilepsy and epilepsy surgery, Rasmussen's encephalitis and medically refractory status epilepticus., Seizure disorder treatment and surgery in brain malformations, seizure manifestations, Sturge Weber syndrome, Tuberous Sclerosis Complex, vagus nerve stimulation, Video EEG, brain malformations causing epilepsy

Awards & Honors

  • Epilepsy Association Legacy Award, 2015
  • Cambridge Who's Who Executive and Professional Registry, since 2006
  • Honorary Membership, Canadian Association for Child Neurology, 1999
  • Marquis Who's Who in Science and Engineering, since 1998
  • America’s Top Doctors, Castle Connolly Medical Ltd, since 1998
  • Marquis Who's Who in America, since 1995
  • Marquis Who's Who in the World, since 1995
  • Best Doctors in America, since 1994
  • US News and World Report, Best Doctors in America, since 1994
  • US News and World Report, Best Doctors in Ohio, since 1994
  • Milken Family Foundation / American Epilepsy Society Award for Outstanding Work in Epilepsy Research, 1994

Innovations & Patents

  • Expansion of the pool of pediatric candidates for epilepsy surgery to include carefully selected children and adolescents who have focal lesion seen on MRI, but lack well-localized abnormalities on EEG


  • American Academy of Neurology
  • American Epilepsy Society
  • International League Against Epilepsy   
  • Child Neurology Society
Research & Publications

Research & Publications

See publications for Elaine Wyllie, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 8/11/2021, Dr. Wyllie has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

89 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

20 Patient Comments

Reviewed on Sep 21, 2021

Dr. Wylie is always collaborative with me regarding Justin's health. I appreciate the respect she gives me.

Reviewed on Sep 1, 2021

Our Dr is absolutely amazing!!

Reviewed on Aug 16, 2021

I was very surprised and thankful that we were able to see Dr. Wyllie within a week of calling to schedule.

Reviewed on Aug 16, 2021

My daughter felt so comfortable with Dr. Wyllie. She took the time to explain everything so we could understand what she is going to be looking at and she was very interested in everything we had to say.

Reviewed on Jul 22, 2021

Dr. Wyllie always makes us feel important and takes time to cover any questions we have. We are so fortunate to have her as our daughter's care provider.

Reviewed on Jul 20, 2021

My Virtural appointment experience with Dr.Wyllie was very good! She was very helpful and made me feel comfortable.

Reviewed on Jun 29, 2021

Love Dr Wiley!

Reviewed on Jun 29, 2021

Dr Wiley always listens and helps us make informed decisions

Reviewed on Jun 16, 2021

Dr. Wyllie is very thorough and awesome!

Reviewed on Jun 16, 2021

Jessica loves to see Dr. Wyllie, but phone visits are convenient.

Reviewed on Jun 14, 2021

Dr. Wyllie is the best

Reviewed on Mar 30, 2021

We loved everything especially Dr. Wyllie

Reviewed on Mar 22, 2021

very kind dr who is unparalleled in expertise in pediatric epilepsy.

Reviewed on Mar 18, 2021

Dr. Wylie is very personable and knowledgeable. My son is a new patient of hers, and it appeared she was catching back up on his case by reading notes while on the video with us, which may be normal, but felt like she may have not had a full picture of history in that moment, in order to recommend a plan for him. This has been a very hard year and I don't want anything missed that might change treatment.

Reviewed on Jan 19, 2021

very grateful to get this appointment with Dr. Wyllie for a second opinion.

Reviewed on Jan 8, 2021

We learned more about sons medical concerns in one hour with Dr. Wylie than I had over the past years. She was professional and brought a depth of knowledge.

Reviewed on Dec 30, 2020

Dr. Wyllie is a phenomenal physician. She always LISTENS!!! She has been a continual blessing to my daughter and her health care. I would recommend her to anyone!!!

Reviewed on Dec 30, 2020

Dr. Wyllie is on the short list of one of the best doctors I've experienced in my life.

Reviewed on Nov 27, 2020

Dr. E.Wyllie is amazing her office reached out to us and scheduled an appointment for my son for the same week. Dr. Willie is a very attentive, responsive and caring physician I feel she really cares for her patients and is dedicated to help resolve their seizures.

Reviewed on Oct 7, 2020

Dr. Wyllie is absolutely amazing! She puts our daughter at ease and truly listens to any questions we have!

Related Videos Featuring Elaine Wyllie, MD

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