Department Epilepsy Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Both Adults and Children & Adolescents
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Clinical Trials
  • Early Epilepsy Surgery
  • Epilepsy Pharmacotherapy with Call Office
  • Epilepsy Surgery
  • Epilepsy Surgery And Video Eeg Evaluation
  • Epilepsy Surgery Evaluation
  • Epilepsy Surgery in Adolescents
  • Epilepsy Surgery In Children
  • Pediatric Neurology
  • Signal Analyses of Subdural Recordings
  • Specialized EEG with Stereotactic Depth Electrodes
  • Specialized EEG With Subdural Grids
  • Surgery In Brain Malformations
  • Vagal Nerve Stimulation
  • Video EEG Monitoring
View all 15 Treatment & Services +

Specialty in Diseases & Conditions

  • Autoimmune Epilepsy
  • Benign Focal Epilepsies and Variants
  • Brain Tumor-Related Epilepsy
  • Clinical Neurophysiology
  • Complex Partial Seizures
  • Cortical Brain Mapping
  • Developmental Disorders Of The Brain
  • Dravet and Doose Syndrome and other Myoclonic Epilepsies
  • Electroencephalogram (EEG)
  • Epilepsy
  • Epilepsy in Adolescents
  • Epilepsy in Children
  • Epilepsy in Infants
  • Epileptic Encephalopathies
  • First Seizure Assessment
  • Focal Cortical Dysplasia
  • Frontal Lobe Epilepsy
  • Genetic & Metabolic causes of Epilepsy
  • Hemispheric Epilepsy
  • Infantile Spasm
  • Intractable (Drug Resistant) Epilepsy
  • Ketogenic Diet
  • Landau–Kleffner Syndrome (LKS)
  • Lennox-Gastaut Syndrome
  • Lissencephaly
  • Malformations Of Cortical Development
  • Medically Refractory Status Epilepticus
  • Mitochondrial Causes of Epilepsy
  • Myoclonic Epilepsy
  • Neurodegenerative Diseases
  • Neurofibromatosis
  • Non-epileptic seizure disorder
  • Post-traumatic Epilepsy
  • Rasmussen Encephalitis
  • Refractory Epilepsy
  • Seizure Manifestations
  • Seizures
  • Seizures - Febrile
  • Seizures After Traumatic Brain Injury
  • Sleep and Epilepsy Issues
  • Status Epilepticus (continuous Seizures)
  • Stroke Causing Seizures
  • Sturge-Weber Syndrome
  • Temporal Lobe Epilepsy (TLE)
  • Tuberous Sclerosis Complex
  • West Syndrome
View all 46 Specialties +


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About Elaine Wyllie, MD

Dr. Elaine Wyllie, Professor, Cleveland Clinic Lerner College of Medicine, is a world renowned thought leader in neurology and epilepsy. She has been on the Castle Connolly list of America’s Best Doctors for many years, as well as on several other national and regional Top Doctors lists. Her many honors and awards include the highly competitive Award for Outstanding Work in Epilepsy Research from the Milken Family Foundation and the Cleveland Clinic Lifetime Achievement Award for Master Clinician.

Dr. Wyllie is editor of the leading medical textbook in the field, Wyllie's Treatment of Epilepsy, now in its sixth edition, which informs physicians in countries on every continent. She also authored The Cleveland Clinic Guide to Epilepsy, an authoritative book for the lay public.

Dr. Wyllie has published over 250 reports on her research in epilepsy in scientific journals. Throughout her career she has championed offering early surgery to infants and children with uncontrolled seizures, to reduce suffering and maximize developmental potential. Her current research, expanding and redefining key aspects of the selection criteria for epilepsy surgery candidates, is influencing clinical practice at epilepsy centers throughout the world. She lectures extensively and has presented her research at over 500 scientific meetings and visiting professorships worldwide.

Dr. Wyllie is certified by the American Boards of Pediatrics, Sleep Medicine, and Psychiatry and Neurology, with Special Competency in Pediatric Neurology. During her training in neurology, epilepsy, and clinical neurophysiology, she won the Cleveland Clinic Neuroscience Residents’ Research Award three years in a row, as well as the Cleveland Clinic Lower Scientific Paper Award. After her training she joined the professional staff of Cleveland Clinic to establish the pediatric epilepsy program, which grew under her leadership into one of the largest and most respected programs in the world. She then led Cleveland Clinic’s Center for Pediatric Neurology through a period of explosive growth to become ranked in 2012 as the number one program in Ohio for the fifth consecutive year and one of the top three programs in the country by US News & World Report.

Together with her colleagues in Cleveland Clinic’s Epilepsy Center, Dr. Wyllie built long referral lines for innovative medical or surgical treatment of children with epilepsy. An active clinician, she attracts personal referrals from physicians worldwide for consultation on the most challenging cases.

Dr. Wyllie has organized and directed over 40 national and international courses and scientific meetings. Her innovations include founding the first annual Cleveland Clinic International Epilepsy Symposium and the first annual American Epilepsy Society Pediatric State-of-the-Art Symposium and Scientific Highlights Session. She has served on the editorial boards of several scientific journals and on the executive boards and committees of several national and international scientific societies.

Dr. Wyllie has trained and mentored hundreds of young physicians in adult and pediatric neurology and epilepsy, many of whom are now recognized as experts and leaders in the field. Trainees presenting her mentored research have won the Thomas Award for Neuroscience Research at Cleveland Clinic, the American Epilepsy Society Young Investigator Award, the Cleveland Clinic Neuroscience Residents’ Research Award, the Cleveland Clinic Epilepsy Fellows Research Award, and the Charles Locok Award for Epileptology from the German Society for Neuropediatrics.

Now that her two sons are grown and pursuing their own exciting careers in science and technology, Dr. Wyllie’s serious hobby is ballroom dancing with coaching on a professional level. She is privileged to share her life with her husband, colleague, and dancing partner, Dr. Robert Wyllie, Professor, Cleveland Clinic Lerner College of Medicine, and Chief of Medical Operations at Cleveland Clinic.  If you are interested to see another side of her life, you may view some of Dr. Wyllie’s dance videos at

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Epilepsy and Clinical Neurophysiology
Cleveland, OH USA

Residency - Cleveland Clinic
Pediatric Neurology
Cleveland, OH USA

Residency - Case Western Reserve University - University Hospitals of Cleveland
Cleveland, OH USA

Residency - Indiana University Medical Center
Indianapolis, IN USA

Medical Education - Indiana University School of Medicine
Indianapolis, IN USA

Professional Highlights

  • Professor, Cleveland Clinic Lerner College of Medicine with Case Western University.
  • Certified by the American Boards of Pediatrics and Psychiatry and Neurology, with Special Competencies in Pediatric Neurology and Epilepsy
  • Editor of the leading medical textbook in the field, Wyllie’s Treatment of Epilepsy, now in its sixth edition.
  • Author of The Cleveland Clinic Guide to Epilepsy, an authoritative book for the lay public.
  • A world renowned thought leader in epilepsy medicine who lectures widely and has published over 250 reports on her research in epilepsy in scientific journals.
  • Recipient of many honors and awards, including the prestigious Career Award for Outstanding Work in Epilepsy Research from the American Epilepsy Society.
  • An active clinician who cares for children with all forms of epilepsy and attracts personal referrals from physicians worldwide for consultation on the most challenging cases.
  • A champion for recognizing opportunities for offering early epilepsy surgery to infants and children with uncontrolled seizures, to reduce suffering and maximize developmental potential.


  • Pediatrics
  • Psychiatry and Neurology - Neurology with Special Qualifications in Child Neurology
  • Psychiatry and Neurology - Epilepsy
  • Neurology with Special Qualification in Child Neurology
  • - Pediatrics - General Cert
  • - Neurology with Special Qualifications in Child Neurology - G
  • - Epilepsy - Subspecialty Cert

Specialty Interests

Children with complex epilepsies, children with epilepsy and Sturge Weber Syndrome, children with first seizure, clinical drug trials, clinical neurophysiology, diagnostic video EEG for pediatric seizure disorders, EEG, Epilepsy, epilepsy and epilepsy surgery in children and adolescents, Epilepsy surgery and medical treatment of epilepsy in children, invasive EEG monitoring for pre-surgical evaluations, Pediatric Epilepsy, pediatric epilepsy and epilepsy surgery, Rasmussen's encephalitis and medically refractory status epilepticus., Seizure disorder treatment and surgery in brain malformations, seizure manifestations, Sturge Weber syndrome, Tuberous Sclerosis Complex, vagus nerve stimulation, Video EEG, brain malformations causing epilepsy

Awards & Honors

  • Epilepsy Association Legacy Award, 2015
  • Cambridge Who's Who Executive and Professional Registry, since 2006
  • Honorary Membership, Canadian Association for Child Neurology, 1999
  • Marquis Who's Who in Science and Engineering, since 1998
  • America’s Top Doctors, Castle Connolly Medical Ltd, since 1998
  • Marquis Who's Who in America, since 1995
  • Marquis Who's Who in the World, since 1995
  • Best Doctors in America, since 1994
  • US News and World Report, Best Doctors in America, since 1994
  • US News and World Report, Best Doctors in Ohio, since 1994
  • Milken Family Foundation / American Epilepsy Society Award for Outstanding Work in Epilepsy Research, 1994

Innovations & Patents

  • Expansion of the pool of pediatric candidates for epilepsy surgery to include carefully selected children and adolescents who have focal lesion seen on MRI, but lack well-localized abnormalities on EEG


  • American Academy of Neurology
  • American Epilepsy Society
  • International League Against Epilepsy   
  • Child Neurology Society
Research & Publications

Research & Publications

See publications for Elaine Wyllie, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 8/22/2019, Dr. Wyllie has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

63 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.8

12 Patient Comments

Reviewed on Jun 22, 2020

I love this physician and her staff. They have been wonderful to work with. we couldn't ask for a better outcome!

Reviewed on Jun 10, 2020

Dr Wyllie was very clear about everything and made sure we understood and were comfortable

Reviewed on May 26, 2020

We cannot thank Dr. Wyllie enough. Her grace, depth of experience, and decency are peerless. Although we had been more than willing to take the trip to see her in person, we respect the need for telehealth. Even on the screen, all of her positive qualities shined through. We do hope that the Clinic recognizes and honors the gem that you have in Dr. Wyllie.

Reviewed on May 15, 2020

Outstanding care provider. Incredibly attentive and thorough.

Reviewed on May 13, 2020

Dr. Wyllie is the consummate personal!

Reviewed on Apr 17, 2020

Dr. Wylie is the best!

Reviewed on Apr 1, 2020

I LOVE that appointments can be scheduled through his doctors office and not having to call a central scheduling

Reviewed on Apr 1, 2020

Dr. Wyllie is the best. We came to her from Cincinnati Children's years ago and it was the best decision we ever made regarding the care of our son. She always has a clear plan of action, explains everything, and asks for our input. We are so thankful she is our sons doctor.

Reviewed on Dec 4, 2019

If I could give Dr. Wylie a 10 rating, I would. She is an amazing Doctor. I wish more doctor's were like her!

Reviewed on Dec 2, 2019

Dr Wylie is very good in her field and we respect that. However, she never greeted our child or interacted with her. She did no observable neurological exam. She thoroughly communicated with us as parents, and attended well to us. However, after driving an hour, waiting in a sterile white waiting room with no toys for 45 minutes, not being welcomed by staff, and then being ignored by a doctor, she had nothing to engage her at all for this appointment. We were turned off by the entirety of our experience.

Reviewed on Nov 11, 2019

Our testing ended earlier than expected and Dr. Wyllie was able to accommodate our schedule and see us 4 hours earlier than originally scheduled to see her.

Reviewed on Aug 5, 2019

the doctor is typically amazing, however this date she was short with us and seemed rushed.

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