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Department Colorectal Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon Yes
Locations Specialties & Treatments

Treatment & Services

  • Abdominal Perineal Resection
  • Abdominal Surgery
  • Advanced Laparoscopic Surgery
  • Advanced Operative Laparoscopy
  • Anorectal Fistula Treatment
  • Anorectal Surgery
  • Anoscopy
  • Clinical Trials
  • Colectomy
  • Colon And Rectal Surgical Procedures
  • Colon Surgery
  • Colonoscopy
  • Colorectal Cancer - Prevention
  • Colorectal Cancer Diagnosis
  • Colorectal Cancer Research
  • Colorectal Cancer Screening Strategies
  • Colorectal Cancer Treatment
  • Colorectal Surgery
  • Colostomy
  • Fecal Diversion
  • Flexible Sigmoidoscopy
  • Hemorrhoidectomy
  • Ileoanal Pouch
  • Ileostomy
  • Intestinal Stomas
  • J Pouch
  • Laparoscopic Abdominal Perineal Resection
  • Laparoscopic Colectomy
  • Laparoscopic Colon Resection
  • Laparoscopic Colon Surgery
  • Laparoscopic Colorectal Surgery
  • Laparoscopic Fecal Diversion
  • Laparoscopic Ileocolectomy
  • Laparoscopic J-pouch Surgery
  • Laparoscopic Proctosigmoidectomy
  • Laparoscopic Surgery
  • Laparoscopic Surgery for Digestive Diseases
  • Laparoscopy
  • Lesbian Gay Bisexual and Transgender( LGBT Health)
  • Minimally Invasive Colorectal Surgery
  • Pelvic Pouch Surgery for Ulcerative Colitis
  • Pouch Center
  • Pouchoscopy
  • Rectal Cancer Surgery
  • Rectum Reoperative Abdominopelvic Surgery
  • Re-Do Rectal Surgery
  • Reoperative Abdominal and Pelvic Surgery
  • Reoperative Abdominal Surgery
  • Reoperative Pelvic Surgery
  • Reoperative Surgery
  • Resection of Colon and Rectal Diseases
  • Rigid Sigmoidoscopy
  • Robotic Colorectal Surgery
  • Robotic Female Surgery
  • Robotic Surgery
  • Robotic-Assisted Laparoscopic Surgery
  • Rubber Band Ligation Of Hemorrhoids
  • Second Opinion
  • Sphincter Sparing Surgery
  • Stoma Surgery
  • Strictureplasty
  • Surgery
  • Surgery For Carcinoma Of The Colon
  • Surgery For Crohn's Disease
  • Surgery for Crohn's Disease and Ulcerative Colitis
  • Surgery for Rectovaginal Fistula
  • Surgical Management for Ulcerative Colitis
  • Surgical Treatment for Mucosal Ulcerative Colitis
  • Total Abdominal Colectomy
  • Tracheal Intubation
  • Treatment for Anal Fissure
  • Treatment for Anal Fistula
View all 72 Treatment & Services +

Specialty in Diseases & Conditions

  • Abdominal Abscess
  • Adenomatous Polyps
  • Anal Abscesses
  • Anal Cancer
  • Anal Fissures
  • Anal Fistula
  • Benign Anorectal Disease
  • Cancer
  • Cancer of the Colon, Rectum and Anus
  • Carcinoma of the Colon
  • Carcinoma of the small and large bowel
  • Colon Cancer
  • Colon Diseases
  • Colon Polyps
  • Colonic Neoplasia
  • Colovaginal Fistula
  • Colovesticle Fistula
  • Crohn's Disease
  • Diverticulitis
  • Diverticulosis
  • Diverticulum
  • Enterocutaneious Fistula
  • Fissure
  • Hemorrhoids
  • Inflammatory Bowel Disease (IBD)
  • Intestinal Fistula
  • Intestinal Fistulae
  • Intestinal Ischemic Syndrome
  • Large Bowel Cancer
  • Large Intestine Cancer
  • Small Bowel Cancer
  • Small Intestine Cancer
  • Stoma Related Problems
  • Ulcerative Colitis
  • Volvulus
View all 35 Specialties +


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About Amy Lightner, MD

Dr. Lightner is an Associate Professor of Surgery in the Department of Colon and Rectal Surgery at Cleveland Clinic, OH and associate chief of surgical research, and is the Primary Investigator of the surgical inflammatory bowel disease translational laboratory.  Thus, her time is split between operating, conducting research, and overseeing/directing the research fellows in colorectal surgery.

Prior to coming to Cleveland Clinic, she completed her surgical training in General Surgery at University of California at Los Angeles and post-doctoral work at Stanford University under a California Institute of Regenerative Medicine Training Grant focused on the differentiation pathways of embryonic stem cells.  After completing her fellowship at Mayo Clinic, she stayed on as surgical faculty and was the Director of the Translation, Implementation and Practice Platform within the Center for Regenerative Medicine at Mayo Clinic, enterprise-wide. She was recruited to Cleveland Clinic for her translational laboratory work and clinical trial work in stem cell therapy for Crohn’s disease.

Dr. Lightner has received an extramural career development award to study the use of stem cell based therapies for IBD and has received additional internal funding for ongoing clinical trials in stem cell based therapy for perianal and rectovaginal fistulizing Crohn’s disease.  In addition, she is currently the primary investigator of a multi-center international randomized control trial studying a variation in surgical technique for ileocolic Crohn’s disease and the primary investigator for an industry sponsored trial for stem cell therapy in Crohn’s disease. she is a member of the editorial board of Inflammatory Bowel Diseases, Colorectal Disease and Diseases of the Colon and Rectum, is the surgical chair for the Crohn’s and Colitis Foundation annual meeting, and is the associate chair of the IBD committee within the American Society of Colon and Rectal Surgeons. She is considered a leading expert in regenerative surgery and how it applies to IBD and is regularly invited to give talks nationally and internationally on this topic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Mayo Clinic
Colon & Rectal Surgery
Rochester, MN USA

Residency - David Geffen School of Medicine @ UCLA
General Surgery
Los Angeles, CA USA

Medical Education - Boston University School of Medicine
Boston, MA USA

Undergraduate - Stanford University School of Medicine
Human Biology
Stanford, CA USA

Additional Training

  • Postdoctoral fellowship in Stem Cell Biology at Stanford University

Professional Highlights

  • Stem cell therapy for Crohn's disease
  • Reconstructive pouch surgery


  • Surgery - General Surgery
  • Colon and Rectal Surgery

Specialty Interests

inflammatory bowel disease, stem cell therapy, pouch reconstruction

Awards & Honors

  • Sherman Prize for Emerging Leader in Inflammatory Bowel Disease. Awarded to an emerging leader in inflammatory bowel disease with monetary support for research endeavors. 2018.

    2018 Transform the Practice Award, Translational work cost for “The intra-arterial delivery of mesenchymal stem cells for the treatment of luminal Crohn’s disease: safety, efficacy, and its implications for disease discovery.” Primary Investigator, Mayo Clinic, Rochester MN, 2019-2021.

    Center for Regenerative Medicine Research Award, The local delivery of mesenchymal stem cells for the treatment of fistulas related to Crohn’s disease of the pouch” Primary Investigator, Mayo Clinic, Rochester MN, 2019-2021.

    Center for Regenerative Medicine Research Award, The local delivery of mesenchymal stem cells for the treatment of rectovaginal fistulas related to Crohn’s disease” Primary Investigator, Mayo Clinic, Rochester MN, 2019-2021.

    2018 Department of Surgery Small Research Grant, Translational work cost for Mesenchymal Stem Cells for Fistulizing Crohn’s Disease: Optimizing the Cellular Product for Future Investigation.”Primary Investigator, Mayo Clinic, Rochester MN, 2018-2020.

    2018 Research Career Support and Advancement Award, Translational work cost for “The intra-arterial delivery of mesenchymal stem cells for the treatment of luminal Crohn’s disease: safety, efficacy, and its implications for disease discovery.”, Primary Investigator, Mayo Clinic, Rochester MN, 2018-2020.

    American Society of Colon and Rectal Surgeons Career Development Award, Targeted, intra-arterial delivery of mesenchymal stem cells for the treatment of luminal Crohn’s disease, Primary Investigator, Mayo Clinic, Rochester MN, 2018-2020.

    Advance the Practice Research Award, Imaging biomarkers derived from integrated Time-of-flight (TOF) FDG PET/MR Enterography for differentiating predominantly fibrotic from predominantly inflammatory enteric strictures in patients with Crohn's disease, Co-Investigator, Mayo Clinic, Rochester MN, 2018-2020.

    Center for Regenerative Medicine 2016 Career Development Regenerative Medicine Award, Career Development Award, Translational work cost for “Angiographic delivery of mesenchymal derived stem cells for the treatment of severe medically refractory Ulcerative colitis (UC)”, Mayo Clinic, Rochester, MN, 2016-2018.

    California Institute of Regenerative Medicine (CIRM) Training Grant, Stem Cell Biology (TG2-01159), 2010-2012.

    Training Grant, Molecular and Cellular Immunobiology (5 T32 AI07290), 2010-2011.


  • 2018-present Associate Editor, Diseases of the Colon and Rectum

    2017-present Associate Editor, Colorectal Disease

    2017-present Associate Editor, Inflammatory Bowel Disease

    2017-present CCF Abstract Review Committee

    2017-present CCF Chair of Surgical Planning Committee

    2017-present ASCRS Practice Guideline Writing Committee

    2017-present ASCRS Associate Chair of the Inflammatory Bowel Disease Committee

    2015-present Member, European Crohn’s and Colitis Organization

    2015-present Member, American Society of Colon and Rectal Surgeons

    2015-present Member, Surgical Society of the Alimentary Tract

    2015-present Member, Crohn’s and Colitis Foundation

Research & Publications

Research & Publications

See publications for Amy Lightner, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 2/15/2022, Dr. Lightner has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Lightner receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Mesoblast, Inc.
  • Ossium Health, Inc.
  • Boomerang Medical

Fiduciary Role. Dr. Lightner serves in a fiduciary capacity, such as an elected officer, director or chief medical officer, for the following companies or other entities:

  • RegenTX, LLC

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

96 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.7 out of 5
Explains 4.7
Listens 4.6
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.7

11 Patient Comments

Reviewed on Aug 23, 2022

Dr Amy Lightner was professional and caring. Very comfortable in her care.

Reviewed on Jul 12, 2022

I am forever grateful for care, and kindness ,as well as the new beginning Dr. Lightner has given me.

Reviewed on Jul 12, 2022

This doctor was fantastic. She was easy to talk to. She listened and answered all my questions and I felt like my quality of life mattered to her. I hope she can help me If I get Into difficulty. Still hoping for transdermal stimulator belt In the future.

Reviewed on Jun 28, 2022

Doctor was very nice and knowledgeable

Reviewed on Feb 8, 2022

Fantastic experience! Dr. Lightner is the absolute best!!

Reviewed on Feb 8, 2022

Dr Lightner is always forthcoming about information, she is down to earth and professional and very easy to talk to. It is frustrating for all of us regarding supply chain and other things holding up her stem cell trial, but she is very open about letting patients know what's going on , to the best of her knowledge.

Reviewed on Feb 8, 2022

Always a great experience from Dr Lightner to her nurse Amy and to the people who schedule appointments.

Reviewed on Jan 11, 2022

Outstanding service! I have recommened the clinic to many! Dr. Amy litghtner an amazing surgeon and dr. She is a talented, informed and caring Dr. She actually saved my life. I would considerner no Dr. Other than her!

Reviewed on Jan 11, 2022

Dr. Lightner is the best CRS that I've had so far and I've now been through 2 others. She is knowledgeable, compassionate and understanding. She always answers my questions and explains the best possible treatment plan for my health issues.

Reviewed on Nov 30, 2021

Dr Lightner was very kind and responsive to my questions and needs. She promptly answered all questions and gave advise for medical needs.

Reviewed on Oct 19, 2021

It was black and white with the doctor, can have surgery or not. Other than saying add more fiber to my diet, offered no other guidance on relief if not wanting to have a procedure done. I brought up a few questions/ideas on relief for my issue and she agreed but was not very pro-active. I kept asking some questions for relief solutions and finally the nurse/assistant offered a compound the pharmacy has that may be helpful. Doctor agreed with that option. I asked for the compound prescription, but felt the doctor really didn't care at all about my situation. Said if I decide to have them removed in the future I would just need to call to schedule. To me, it's very personal but I did not feel to her it mattered.

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