Department Mellen Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No

Additional Locations

Mellen Center

Fairview Hospital

18101 Lorain Avenue
Cleveland, OH 44111
Driving Directions

Specialties & Treatments

Treatment & Services

  • Botulinum Toxin Injections
  • Consultation and Long-term Care
  • Intrathecal Baclofen Pump
View all 3 Treatment & Services +

Specialty in Diseases & Conditions

  • Acute Disseminated Encephalomyelitis (ADEM)
  • Devic's Disease (Neuromyelitis Optica)
  • Multiple Sclerosis
  • Neuroimmunology
  • Optic Neuritis
  • Transverse Myelitis
View all 6 Specialties +


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About Mary Willis, MD

Mary Alissa Willis, MD is a Staff Neurologist in the Neurological Institute's Mellen Center for Multiple Sclerosis at Cleveland Clinic. She graduated summa cum laude from the University of Mississippi Medical Center in Jackson, Mississippi, where she developed an interest in multiple sclerosis as a medical student working with Dr. Robert Herndon. Dr. Willis served as Chief Resident of her neurology residency program before moving to Cleveland for fellowship training in Clinical Neuroimmunology.

In addition to caring for people with multiple sclerosis, Dr. Willis participates in clinical trials at the Mellen Center and enjoys opportunities to teach medical students and neurology residents. She is the Chair of the Outcomes and Quality Committee at the Mellen Center and serves on a national committee to develop standards of care for MS.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - University of Mississippi Medical Center
Jackson, MS USA

Internship - University of Mississippi Medical Center
Internal Medicine
Jackson, MS USA

Medical School - University of Mississippi Medical Center
Jackson, MS USA

Undergraduate - Mississippi State University
Chemical Engineering
Mississippi State, MS USA


  • Neurology

Specialty Interests

Multiple sclerosis and other demyelinating disorders Spasticity management Medical student and resident education

Awards & Honors

  • 2011 Alpha Omega Alpha Resident Teacher of the Year
    2011 Jackson VA Medical Center Neurology Resident of the Year
    2010, 2011 Gold Foundation Humanism and Excellence in Teaching Award
    2007 AAN Medical Student Prize for Excellence in Neurology
    2007 Neuroscience Critical Care Achievement Award
Research & Publications

Research & Publications

See publications for Mary Willis, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/20/2017, Dr. Willis has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Willis receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Genzyme Corporation
  • Biogen Idec, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

148 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.9
Courtesy, Respect & Concern 4.9
Knows Medical History 4.9
Time Spent with Patient 4.9
Patient Rating of Doctor 4.9

18 Patient Comments

Reviewed on Jan 18, 2018

I left hopeful about finally having a tool to control my chronic nerve pain, as several drugs were discussed that would be conducive to maintaining my weight, while even stabilizing my mood.

Reviewed on Jan 4, 2018

Dr Mary Willis always takes as much time with me as I need. she is very thorough and answers any questions I may have. Dr. Willis is the most caring and compassionate doctor I have ever had.

Reviewed on Jan 4, 2018

Dr. Willis is very thorough in answering medication questions and explanations as well as long-term care plan.

Reviewed on Dec 29, 2017

*Dr. Willis was very direct and compassionate. One could tell she cared.

Reviewed on Dec 7, 2017

This doctor,(Dr. Willis), is absolutely the finest and most caring physician I have ever had provide medical care for me.

Reviewed on Oct 16, 2017

Dr. Willis gave me options about 2 possible medications. She asked me to go home and look them up, discuss them with my husband and get back to her once I come off my current med. She didn't decide for me. She gave me her recommendation but wants me to be part of decision. No doctor has ever really done that before

Reviewed on Sep 22, 2017

I left completely satisfied with our action plan, which is unfortunately rare in my past experiences with other doctors.

Reviewed on Aug 24, 2017

I abslutely LOVE Dr. WIllis. She has a very calm bedside manner and makes me feel like she genuinely care about y health and wellbeing rather than just another face. She is attentive to me and answers my questios in a way that is easy for a non-medical professional to understand.

Reviewed on Aug 24, 2017

Dr. Willis is an excellent doctor. I only see her twice a year but I feel like she reviews my records prior to each of my appointments so she knows exactly our plan and what we discussed at the last appointment. She explains everything so thoroughly and offers great advice and treatments. I would be hard pressed to find another provider that is better than Dr. Willis.

Reviewed on Aug 14, 2017

Dr. Willis is exceptional. My husband and I are so happy with my care. She is personable, kind, and seems genuinely concerned for my well-being. So professional and knowledgeable. I am so confident in her care for me. I feel blessed to have the ability to drive two hours to be seen at the Mellen center because I truly believe that there is no better place to receive care for my diagnosis. Thank you Dr Willis, Malissa, Marie, and the rest of your team.

Reviewed on Aug 11, 2017

dr Willis is phenomenal. She is thorough, patient, and clearly has a passion for her field and her patients.

Reviewed on Aug 8, 2017

Dr. Willis is always very attentive to what I'm saying and very thorough in her explanations.

Reviewed on Jul 7, 2017

Dr. Willis is the most compassionate, caring and understanding Physician I have ever met. I am so grateful to have found her. I feel my health is finally in control because of her!!

Reviewed on Jul 6, 2017

Dr really listens when we ( me and my husband) asks questions

Reviewed on Jun 29, 2017

never had a bad experience always good. love Dr. Willis.

Reviewed on Jun 15, 2017

Dr. Willis is the most attentive and detail oriented clinician I have had the pleasure to have.. many physicians could learn from her. she is wonderful.

Reviewed on Mar 27, 2017

Best doctor I could ask for.

Reviewed on Feb 9, 2017

Dr. Willis stayed in touch with me through MyChart, answering questions and offering support.

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