Department Mellen Center
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No

Additional Locations

Mellen Center

Fairview Hospital

18101 Lorain Avenue
Cleveland, OH 44111
Driving Directions

Specialties & Treatments

Treatment & Services

  • Botulinum Toxin Injections
  • Consultation and Long-term Care
  • Intrathecal Baclofen Pump
View all 3 Treatment & Services +

Specialty in Diseases & Conditions

  • Acute Disseminated Encephalomyelitis (ADEM)
  • Devic's Disease (Neuromyelitis Optica)
  • Multiple Sclerosis
  • Neuroimmunology
  • Optic Neuritis
  • Transverse Myelitis
View all 6 Specialties +


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About Mary Willis, MD

Mary Alissa Willis, MD is a Staff Neurologist in the Neurological Institute's Mellen Center for Multiple Sclerosis at Cleveland Clinic. She graduated summa cum laude from the University of Mississippi Medical Center in Jackson, Mississippi, where she developed an interest in multiple sclerosis as a medical student working with Dr. Robert Herndon. Dr. Willis served as Chief Resident of her neurology residency program before moving to Cleveland for fellowship training in Clinical Neuroimmunology.

In addition to caring for people with multiple sclerosis, Dr. Willis participates in clinical trials at the Mellen Center and enjoys opportunities to teach medical students and neurology residents. She is the Chair of the Outcomes and Quality Committee at the Mellen Center and serves on a national committee to develop standards of care for MS.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - University of Mississippi Medical Center
Jackson, MS USA

Internship - University of Mississippi Medical Center
Internal Medicine
Jackson, MS USA

Medical School - University of Mississippi Medical Center
Jackson, MS USA

Undergraduate - Mississippi State University
Chemical Engineering
Mississippi State, MS USA


  • Neurology

Specialty Interests

Multiple sclerosis and other demyelinating disorders Spasticity management Medical student and resident education

Awards & Honors

  • 2011 Alpha Omega Alpha Resident Teacher of the Year
    2011 Jackson VA Medical Center Neurology Resident of the Year
    2010, 2011 Gold Foundation Humanism and Excellence in Teaching Award
    2007 AAN Medical Student Prize for Excellence in Neurology
    2007 Neuroscience Critical Care Achievement Award
Research & Publications

Research & Publications

See publications for Mary Willis, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/22/2018, Dr. Willis has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Willis receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Biogen Idec, Inc.
  • Novartis Pharmaceuticals Corporation
  • Sanofi Genzyme

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

138 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 5
Knows Medical History 4.9
Time Spent with Patient 5
Patient Rating of Doctor 4.9

23 Patient Comments

Reviewed on Mar 18, 2019

great experience and doctor listened, asked questions and genuinely felt she cared

Reviewed on Feb 18, 2019

Dr. was thorough and it was a great first experience with the doctor and her practice.

Reviewed on Jan 28, 2019

I believe that Dr. Willis is genuinely interested in helping me get better.

Reviewed on Dec 31, 2018

Dr. Willis is the most knowledgeable Neurologist that I have seen in the 15 years of having Multiple Sclerosis. She was very informative of every aspect of the disease. She explained my past MRI results in detail, completed a series of exams testing my reactions and balance, and explained to me a detailed treatment plan to work with traveling in excess of 6 hours. She is very professional and gives off an evident vibe of truely caring and understanding what I'm going through on a daily basis.

Reviewed on Dec 14, 2018

Dr Willis is fabulous. I was hoping for a great replacement for my former doctor at the Mellen Center who has retired. I finally found the best possible replacement and feel complete confidence in Dr Willis!

Reviewed on Nov 23, 2018

Dr. Willis was very caring and supportive, and provided excellent advice about my treatment at the Mellen Center and also about its interactions with other serious health problems I have now. She was very knowledgeable about all these other problems, and after consulting with those other providers she gave me very clear and helpful advice about my future treatment regarding MS, Neurology, and related problems. I am very grateful to be under her care.

Reviewed on Nov 6, 2018

This was my first visit with Dr Willis and it was a very good experience for a first time visit .

Reviewed on Nov 1, 2018

Dr. Willis is the best doctor I've seen since my diagnosis. She's courteous, respectful, gentle, EXTREMELY knowledgeable and has a great bedside manner. I really appreciate that she will stop and explain any question I have.

Reviewed on Oct 22, 2018

Dr Willis is professional, knowledgeable, courteous and has changed my life with her recommendations.

Reviewed on Oct 18, 2018

Dr Willis is a genius. She really pays attention to all my different medical issues when she treats my MS. Great listener, and she remembers everything.

Reviewed on Oct 18, 2018

Dr Willis is extremely thorough, yet you never feel like there is too much information.

Reviewed on Aug 31, 2018

Excellent experience every time. I use MyChart often to communicate with my medical provider rather than phone calls. They have excellent response time.

Reviewed on Aug 31, 2018

Dr Willis is very clear when it comes to explaining medications and treatment.

Reviewed on Aug 16, 2018

very happy with Dr. Willis and her expertise.

Reviewed on Aug 9, 2018

I found the doctor I need. She took time to teach me and my wife about MS. My wife and I left feeling hopeful that I can feel better. She listened and heard what I said, I've never had a doctor walk me to the exit and that was a compassionate touch.

Reviewed on Aug 2, 2018

my overall experience was really good and Dr Willis was great. she listened to what I had to say and she was very thorough going over my medical records.

Reviewed on Jul 27, 2018

I have really appreciated Dr. Willis and her team being willing to take adequate time to not only explain the diagnosis, but to listen with compassion and understanding to all of the things that are going on in my life as contributing factories to my illness.

Reviewed on Jul 12, 2018

Every time I see Dr. Willis it is an easy, worry-free appointment. She is, out of the 5 physicians I see for my disease, by far the most personal, professional, and thorough doctor I interact with. From the office staff, to the PA's, to Dr. Willis, I am treated with a friendly, professional courtesy that I am truly greatful for.

Reviewed on Jul 12, 2018

Dr. Willis is the consummate professional. She talks about my health, the procedure I'm having, and any questions I have. She, nor the staff, has never made me feel rushed during my appointments.

Reviewed on Jun 27, 2018

Dr. Willis is absolutely AWESOME. She is definitely a class act. I absolutely LOVE her.

Reviewed on Jun 25, 2018

Dr. Willis exceeded my expectations. she explained more in one visit than several other doctors have. I've been to an Opthamologist, Neurologist, Neuro Optho and always seemed to leave with questions. Dr. Willis answered all of my questions and explained things in a way that not only could I understand, but put my mind at ease!

Reviewed on Jun 8, 2018

Dr. and Resident were very thorough and very caring.

Reviewed on May 21, 2018

Dr. Willis was very caring and supportive and provided very clear and careful advice about my future treatment. I am very grateful to be under her care.

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