Darlene A. Lobel, MD

Darlene A. Lobel, MD
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Department Center for Neuro-Restoration
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, French
Surgeon Yes
Locations Specialties & Treatments

Treatment & Services

  • Brain Biopsy
  • Brain Surgery
  • Brain Tumor Surgery
  • Deep Brain Stimulation (DBS)
  • Gamma Knife Radiosurgery
  • Gamma Knife Treatment
  • Intrathecal Baclofen Pump
  • Neurological Surgery
  • Spinal Cord Stimulation
View all 9 Treatment & Services +

Specialty in Diseases & Conditions

  • Benign Brain Tumors
  • Brain Metastases
  • Chronic Neuropathic Pain
  • Depression
  • Dystonia
  • Essential Tremor Resources
  • Malignant Tumors of the Brain
  • Obsessive-Compulsive Disorder (OCD)
  • Parkinson's Disease
  • Spasticity
  • Tourette Syndrome
View all 11 Specialties +


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About Darlene A. Lobel, MD

Darlene A. Lobel, MD, is a Staff Neurosurgeon in the Center for Neurological Restoration in the Neurological Institute and an Associate Professor of Surgery at the Cleveland Clinic Lerner College of Medicine. Dr. Lobel performs Deep Brain Stimulation (DBS) surgery for patients with Parkinson's Disease, tremor, dystonia, and psychiatric disorders, as well as procedures for patients with intractable pain syndromes and spasticity. She also performs stereotactic biopsy and resection of brain tumors as well as gamma knife radiosurgery for tumors and movement disorders. She holds joint appointments in the Department of Biomedical Engineering and in the Gamma Knife Center.

Dr. Lobel received her Bachelor of Science degree from Duke University and her Medical Doctorate from the Medical College of Georgia in 2000.  She completed her residency in neurological surgery at MCG in 2006.  She then pursued fellowship training in stereotactic neurosurgery and radiosurgery at UCLA, and further training in functional neurosurgery and epilepsy surgery at Emory University, completing her fellowship there in 2007. She held academic positions at both UCLA and Emory during her fellowship training, dedicating her time to educating residents and other clinicians.

Dr. Lobel was recruited to the University of Florida-Jacksonville in 2007 as an Assistant Professor of Neurosurgery, where she built up a busy subspecialty practice in deep brain stimulation and spinal cord stimulation. In 2009, she was recruited to a practice in Georgia, where she served as Chief of Neurosurgery for her private practice group until 2011. 

In 2011, Dr. Lobel was invited to work in Grenoble, France with Dr. Alim-Louis Benabid, the founder of modern day Deep Brain Stimulation (DBS) for treatment of Parkinson's Disease.  During the 18 months working with Dr. Benabid, Dr. Lobel enhanced her knowledge of DBS, while also working on the development of a Brain Computer Interface (BCI) system for patients with traumatic spinal cord injury.  At Clinatec, a biomedical translational research facility in Grenoble, Dr. Lobel worked closely with a multi-disciplinary team of engineers, technicians, mathematicians, informaticians, biologists, and other medical doctors on the design and implementation of the BCI system conceived by Dr. Benabid. She developed a passion for this research during her tenure in France, and now continues to conduct research in BCI systems at Cleveland Clinic.   

Dr. Lobel was recruited to Mayo Clinic while she was working in France, to serve as a liaison between Clinatec and Mayo Clinic in the development of a clinical research protocol involving both centers.  In addition to facilitating this research collaboration, Dr. Lobel was integrally involving in a preclinical research trial using intraspinal microstimulation (ISMS) to reanimate paralyzed limbs.  She contributed to the ISMS system design, and served as a neurosurgeon for the trial.  She also served as advisor for PhD candidates and medical students in the lab. In addition to her research contributions, she was involved clinically in the Department of Neurologic Surgery at Mayo, participating in DBS patient management conferences and educating neurosurgery residents through lectures and grand rounds presentations.

In addition to pursuing her clinical interests, Dr. Lobel has dedicated her time to resident education, developing the first neurosurgical course at UF-Jacksonville for residents using simulation based training techniques.  She has served as faculty and course director for educational courses at the AANS and CNS national meetings. One of her greatest contributions to neurosurgical education is her integral role in the development of the Congress of Neurological Surgeons Resident Training Program in Neurosurgical Simulation, created in 2010. She continues to serve as Co-director for CNS sponsored resident simulation courses today.

Dr. Lobel has demonstrated her dedication to clinical expertise, research pursuits, and education. She has made major contributions to the medical and biomedical communities. Dr. Lobel is an internationally acclaimed speaker.  She has served as Co-Investigator and Consultant in clinical trials in the US and in France and has authored several publications, including peer-reviewed manuscripts and book chapters.  Her expertise is widely sought after as a reviewer, invited speaker, and as an expert by other scientists and researchers.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Emory University Hospitals and School of Medicine
Functional Neurosurgery
Atlanta, GA USA

Fellowship - UCLA Medical Center
Sterotactic Neurosurgery
Los Angeles, CA USA

Residency - Medical College of Georgia
Neurological Surgery
Augusta, GA USA

Medical School - Medical College of Georgia
Augusta, GA USA

Professional Highlights

  • Board certified, American Board of Neurological Surgery 2013


  • Neurological Surgery

Specialty Interests

Deep Brain Stimulation for movement disorders, neuropsychiatric disorders, and emerging indications; Frameless Deep Brain Stimulation; Stereotactic Neurosurgery; Spinal Cord Stimulation for chronic pain disorders; Surgical management of spasticity

Awards & Honors

  • Alpha Omega Alpha Honor Society

Innovations & Patents

  • Brain Computer Interface systems for the management of spinal cord injury


  • American Association of Neurological Surgeons
  • American Society for Stereotactic and Functional Neurosurgery Education Committee Member
  • Congress of Neurological Surgeons Simulation Committee
  • Council of State Neurosurgical Societies Executive Committee and Medical Practices Committee Chairperson
Research & Publications

Research & Publications

See publications for Darlene A. Lobel, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 9/6/2017, Dr. Lobel has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

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