Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, Greek
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • General Rheumatology
  • General Rheumatology including Lupus
  • Joint Aspiration
  • Medical Management of Early Osteoarthritis
  • Musculoskeletal Evaluation
  • Musculoskeletal Treatment For Joint Pain
  • Pericardial Diseases Center
  • Rheumatology
View all 8 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Onset Still's Disease
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis of the Foot and Ankle
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Autoinflammatory Syndromes
  • Blau Syndrome
  • Bursitis
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryopyrin Associated Periodic Syndromes (CAPS)
  • Familial Cold Urticaria
  • Familial Mediterranean Fever
  • Familial Mediterranean Fever (FMF) Syndrome
  • Fever of Unknown Origin (FUO)
  • Hip Pain
  • Hyper IgD syndrome (HIDS)
  • Inflammatory Arthritis
  • Joint Disorders
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Majeed Syndrome
  • Muckle-Wells syndrome (MWS)
  • Musculoskeletal Disorders
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis Of The Hips And Knees In The Elderly
  • Osteopenia
  • Painful Joints
  • Periodic Fever Syndromes
  • Periodic Fevers, Aphthous Stomatitis, Pharyngitis, and Adenopathy (PFAPA) Syndrome
  • Rheumatoid Arthritis: How to Treat
  • SAPHO syndrome
  • Schnitzler Syndrome
  • Seronegative Spondyloarthropathies
  • Shoulder Arthritis
  • Spondylitis
  • TNF-Receptor Associated Periodic Syndrome (TRAPS)
View all 41 Specialties +


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About Apostolos Kontzias, MD

Apostolos Kontzias, MD, is a Staff Physician in the Orthopedic and Rheumatologic Institute at Cleveland Clinic. Dr. Kontzias is also an Assistant Professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Dr Kontzias has a research focus on autoinflammatory syndromes which are conditions of innate immunity frequently genetically inherited presenting with fever, rash and arthritis. He is the Director of the Autoinflammatory Clinic which operates within the The R. J. Fasenmyer Center for Clinical Immunology. He has established a biobank registry in collaboration with the Genomics Institute at the Cleveland Clinic and has forged national and international collaborations to study these conditions.
Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - National Institutes of Health
Bethesda, MD USA

Residency - Lincoln Medical and Mental Health Center
Internal Medicine
Bronx, NY USA

Medical School - University of Athens Faculty of Medicine, National & Kapodistrian
Athens, Greece


  • Internal Medicine
  • Internal Medicine - Rheumatology

Specialty Interests

Autoinflammatory diseases Innate Immunity diseases Periodic Fever syndromes Fever of Unknown Origin Familial Mediterranean Fever TNF receptor associated periodic syndrome Cryopyrin associated periodic syndromes (Muckle Wells, Familial cold urticarial, NOMID) Adult onset Still's Disease Spondyloarthritis Ankylosing spondylitis

Research & Publications

Research & Publications

See publications for Apostolos Kontzias, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/24/2017, Dr. Kontzias has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

250 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 5
Knows Medical History 4.8
Time Spent with Patient 4.9
Patient Rating of Doctor 4.8

7 Patient Comments

Reviewed on Feb 26, 2018

Dr. Kontzias is the best! I can't say enough good things about him. When I was so very sick, he took the time to pick apart this big medical mystery, and finally provide the care and answers that my family & I had been searching for. Now, I am free to live life to the fullest, knowing that Dr. Kontzias has everything under control.

Reviewed on Jan 30, 2018

This doctor explained everything so I could understand it and also explained all of the medications and how to take them and what to do with the ones I am presently on by a different provider. Great experience.

Reviewed on Oct 4, 2017

Dr. K was very thorough and helpful,! his colleagues as well

Reviewed on Aug 25, 2017

this physician is the best Rheumatologist I have seen. he explains and listens to your needs as a patient

Reviewed on May 30, 2017

Dr Kontzias is GREAT! I really enjoyed meeting him and talking with him. L feel confident in him.

Reviewed on Mar 22, 2017

Dr. Kontzias was the first doctor who was able to diagnosis my condition (SAPPHO) after 7 months of pain and visits to 10+ doctors at Emory, MD Anderson, and other centers of excellence. He is a hero in my family!

Reviewed on Mar 1, 2017

Dr. Kontzias and his fellow were both wonderful. They both were sincere in their concern for my health and asked questions I would have never thought were of importance. They also explained WHY those questions were important and Dr. Kontzias explained what labs he was ordering and why, as well as what medication he was changing and why.

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