Zavier Nagel: Proof Of Bmt’s Potential In Nonmalignant Diseases
Zavier Nagel (right) was born with congenital amegakaryocytic thrombocytopenia (CAMT), a rare hematologic disease that prevented his bone marrow from making platelets. After a couple of misdiagnoses and unsuccessful treatment attempts, Zavier’s parents brought him to Cleveland Clinic Children’s, where Rabi Hanna, MD, identified Zavier’s CAMT and placed him on a regimen of weekly platelet transfusions.
The transfusions gave Zavier energy but put him at high risk of internal bleeding, so Dr. Hanna suggested a bone marrow transplant. Zavier’s older brother, Jeradt (left), was a match, and an initial transplant of healthy bone marrow from Jeradt to Zavier in October 2011 gave the younger brother an initial boost, but it didn’t last.
In July 2012, Dr. Hanna extracted 20 million stem cells from Jeradt through apheresis and gave them to Zavier. After one more platelet transfusion, Zavier’s platelet count rose and remained high.
Now 6 years old, Zavier is healthy and energetic. Dr. Hanna considers him cured. The Nagels say their boys, who were always close, now share a special bond.