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Research & Clinical Trials

Elucidation of the Risk of Sleep Apnea in Atrial Fibrillation

(NHLBI 1 R01 HL 109493- 01, 2011-2016, PI: R Mehra): Relationships of sleep disordered breathing (SDB) and paroxysmal atrial fibrillation (PAF) will be investigated. Data is collected in order to: clarify the extent that respiratory event frequency, apnea subtype (obstructive versus central), and hypoxia are associated with PAF independent of cardiac structural abnormalities (i.e. systolic dysfunction and increased left atrial volume); explore the extent to which cardiac morphology, pathways of inflammation, oxidative stress and autonomic dysfunction mediate the SDB-PAF relationship and identify whether temporal patterns of AF paroxysms differ in patients with SDB. We will also examine the extent of improvement in AF burden with sleep apnea treatment.

This study is currently active. If you would like more information on this study please contact Joan Aylor, Research Coordinator, at 216.445.1698.

Oxidative Stress in Sleep Apnea and Cardiac Disease

(NIH/NHLBI HL079114 K23 Mentored Patient-Oriented Clinical Research Career Development Award, 2006-2011, PI: R Mehra) The goal is to assess changes in oxidative stress and intermediate cardiovascular measures including vascular stiffness in patients with sleep-disordered breathing who receive CPAP and sham CPAP in a randomized parallel design study.

This study is in analysis phase. If you would like more information on this study please contact Joan Aylor, Research Coordinator, at 216.445.1698.

Phase II Trial of Sleep Apnea Treatment to Reduce Cardiovascular Morbidity

(1RC2HL101417-01, 2009-2012 NHLBI, PI: S Redline, Site PI: R Mehra, Co-Director Electrophysiology Core: R Mehra): The study aims to evaluate the utility of a novel application of nocturnal supplemental oxygen in treating patients at high risk for cardiovascular disease (CVD) events with sleep apnea. This will identify which pathophysiological pathways may be improved by blunting the physiological stress of intermittent hypoxemia compared to improving airway patency. The study will lay the ground work for a definitive Phase 3 study that will address the role of sleep apnea interventions in CVD risk reduction.

This study is in analysis phase. If you would like more information on this study please contact Joan Aylor, Research Coordinator, at 216.445.1698.

Sleep-Related Respiratory and Electrophysiological Atrial Fibrillation Predictors

(NHLBI 1 R21 HL108226-01A1, PI: R Mehra). Perform detailed analysis of the baseline ECG and respiratory data collected from ~3000 MrOS Sleep Study participants and relate these markers of electrical stability (p/t wave propagation) and respiratory related phenotypes to incident arrhythmia.

This study is currently active. If you would like more information on this study please contact Joan Aylor, Research Coordinator, at 216.445.1698.

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