Questions about vaccines, timing, boosters and more? Us, too

COVID-19 vaccines are safe and effective. Everyone five years and older is now eligible to get a free COVID-19 vaccination. See below for information on Pfizer, Moderna and Johnson & Johnson (J&J) vaccines, including timing and dosing.

If you are immunocompromised, please review the specific guidance detailed below.

Pfizer

The Pfizer-BioNTech vaccine, an mRNA vaccine, is recommended for people five years and older.

  • Primary series: two doses, 21 days apart
  • Booster: It is now recommended to receive a booster shot at least five months after the completion of the primary series of Pfizer-BioNTech COVID-19 vaccine for people 12 years and older.
  • Doses for ages 12 and older: Both doses in the primary series as well as boosters are the same product and amount (30 micrograms each).
  • Pediatric dose: Both doses in the primary series for children 5-11 years old is a lower dose (10 micrograms) than the dose used for people 12 years and older (30 micrograms).

Moderna

The Moderna vaccine, an mRNA vaccine, is recommended for people 18 years and older.

  • Primary series: two doses, 28 days apart
  • Booster: People 18 years and older who received a Moderna primary series should get a booster shot at least six months after completing their primary series. You can get any of the COVID-19 vaccines authorized in the United States for your booster shot.
  • Doses: Both doses in the Moderna primary series are the same (100 micrograms each). The booster dose is 50 micrograms.

J&J

In most situations, Pfizer-BioNTech or Moderna COVID-19 vaccines are preferred over the J&J COVID-19 vaccine for primary and booster vaccination due to their reduced risk of serious adverse events. The J&J COVID-19 vaccine may be considered in some situations, including for persons who had a severe reaction after an mRNA vaccine dose or who have a severe allergy to an ingredient of Pfizer-BioNTech or Moderna.

  • Primary series: one dose
  • Booster: Everyone 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna at least two months after receiving the J&J vaccine, in most situations.

Immunocompromised

Pfizer

  • Moderately or severely immunocompromised people 5 years and older should get an additional dose in their primary series at least 28 days after their second dose for a total of three doses.

Moderna

  • Moderately or severely immunocompromised people 18 years and older should get an additional dose in their primary series (third dose) at least 28 days after their second dose.
  • For caregivers who are immunocompromised and are receiving a third dose in their Moderna primary series, please alert the individual administering your vaccine, as the dose amount is different. The Moderna immunocompromised third dose (primary series) is 100 micrograms, whereas the Moderna booster dose is 50 micrograms.

Cleveland Clinic is working to expand vaccine appointments to all populations in the coming weeks. We will provide updates as they become available.