Kidneys for transplantation come from two sources: living donors and deceased (non-living) donors. Living donors are usually immediate family members or sometimes spouses. Deceased donor kidneys usually come from people who have willed their kidneys before their death by signing organ donor cards. Permission for donation can also be given by the deceased person's family at the time of death.
All donors are carefully screened to make sure there is a suitable match and to prevent any transmissible diseases or other complications.
Kidney transplantation involves placing a healthy kidney into the body, where it can perform all of the functions that a failing kidney cannot.
The new kidney is placed on the lower right or left side of your abdomen where it is surgically connected to nearby blood vessels. Placing the kidney in this position allows it to be easily connected to blood vessels and the bladder. The vein and artery of your new kidney are attached to your vein and artery. The new kidney's ureter is attached to your bladder to allow urine to pass out of your body.
In most cases, the diseased kidneys are not removed. There are three conditions that might require your diseased kidneys to be removed:
A successful kidney transplant gives you increased strength, stamina, and energy. After transplantation, you should be able to return to a more normal lifestyle and have more control over your daily living. You can have a normal diet and more normal fluid intake.
If you were dependent on dialysis before the transplant, you'll have more freedom because you won't be bound to your dialysis schedules.
Anemia, a common problem with kidney failure, might be corrected after transplantation. If you have hypertension (high blood pressure), you could be on fewer blood pressure medications after transplantation.
The risks of kidney transplantation are the same as those of any surgery. There is the risk of bleeding, infection or breathing problems. You also might experience some side effects from the medications, and you could be more prone to infections, since the medicine you will take after transplantation lowers your body's ability to fight infection.
There is also the risk of rejection. Since the body recognizes the new kidney as a foreign object, it will normally try to get rid of it or "reject" it. However, you are given medicine to prevent rejection.
Because of years of experience, research, and improved medicines that prevent rejection, kidney transplants are very successful with few complications after transplantation.
You can resume your previous activities as soon as you feel better — and you might even feel good enough to add some new activities. A daily exercise program will continue to improve your health and help you maintain a positive attitude.
You will not injure yourself or your new kidney if you follow some of these general guidelines:
Many kidney transplant patients are able to return to work within a few months following a successful surgery. However, various aspects of the recovery process can affect the timing of your return.
You will need to discuss returning to your job with the Transplant Team. When the time approaches, a “return to work” letter will be provided. This will let your employer know when you may begin working and what limitations, if any, you have.
You may travel after 12 weeks when you are feeling better, but always let the Transplant Team know when you plan to go, and provide a phone number where you can be reached. By remembering these traveling tips, your vacation will be worry free:
There are a few foods and other substances that you should avoid after a kidney transplant. These items can hurt your kidney function and put you at risk for complications. It’s important to follow your healthcare provider’s recommendations on what you should and shouldn’t consume after your transplant. Dietary changes can sometimes be necessary after a kidney transplant, on a short-term basis. If your transplant is working well, you’ll also need to learn about possible interactions with transplant-sustaining drugs. If your new kidney is not doing well, dietary recommendations might be similar to those for chronic kidney disease (CKD).
It’s important that you practice good hygiene to avoid infections when you’re eating. In the first 90 days after surgery, your weakened immune system puts you at high risk for infectious diseases. Your provider will likely advise you to avoid close crowds where contact with an infected person is more likely. When you do go out, be sure to wash your hands frequently and stay away from people who are ill.
When it comes to the food and drinks you consume, there are a few tips you should follow, including:
Although a kidney transplant can cause many life changes, it does not affect a woman’s desire to become pregnant or hinder a man’s ability to father a child.
Although fertility is not a problem, rejection or high blood pressure are both complications a woman might experience for at least one year after transplant surgery. Therefore, it is important to prevent a pregnancy during this time by using birth control.
Women who have a kidney transplant can have a healthy pregnancy later. Talk to the Transplant Team about the timing of your pregnancy after your transplant. Also, know the risks and make sure your obstetric provider is experienced in dealing with transplant patients.
A female transplant patient who becomes a new mother should not breastfeed her baby. The immunosuppressive medicines prescribed after transplantation can be passed through the mother’s breast milk and can cause harm to the baby.
Female transplant patients should be sure to have a yearly Pap test (a test for cancer of the cervix) and a mammogram. Immunosuppressive medicines could cause increased susceptibility to various types of cancer. Pap tests and mammograms are preventive measures that can help your healthcare providers detect any problems.
Cleveland Clinic Transplant Center
9500 Euclid Ave., Desk Q8 Cleveland, OH 44195
216.444.8949 or 1.800.223.2273 ext. 48949
American Society of Transplantation
1120 Route 73, Suite 200
Mt. Laurel, NJ 08054
American Society of Transplant Surgeons
2461 South Clark Street, Ste. 640
Arlington, VA 22202
A collaborative project of the American Society of Transplant Physicians and the American Society of Transplant Surgeons Features Transplant News Network, an online broadcasting service that publishes monthly news reports on recent developments in transplant medicine.
Children's Organ Transplant Association, Inc.
2501 West COTA Drive
Bloomington, IN 47403
International Society of Nephrology
340 North Avenue, 3rd floor
Cranford, NJ 07016
Organ Procurement Organization Serving Northeast Ohio
4775 Richmond Road
Cleveland, OH 44128
1.888.558.LIFE (5433) or 216.752.LIFE (5433)
Nephron Information Center
This is not a complete list and inclusion does not imply endorsement by Cleveland Clinic.
Last reviewed by a Cleveland Clinic medical professional on 03/20/2019.