How could research benefit smokers who want to quit?

Researchers are evaluating different forms of varenicline for quitting smoking. Medications that affect receptors in the central nervous system, such as topiramate (Topamax®) and memantine (Namenda®), are currently being tested in clinical trials as aids to help quit smoking.

In addition, a clinical trial is studying a form of electronic cigarette that does not contain nicotine given along with counseling as an early method to reduce or quit smoking.

Last reviewed by a Cleveland Clinic medical professional on 05/01/2015.


  • Nides M. Update on Pharmacologic Options for Smoking Cessation Treatment. The American Journal of Medicine. (2008). Vol.121(4A)S20-S31.
  • Tom W-C. Smoking Cessation Drug Therapy: An Update. Pharmacist's Letter/Prescriber's Letter. January 2011-Vol.27-No. 270111
  • Leonard M. Medications Used for Smoking Cessation. Pharmacotherapy Update from the Cleveland Clinic Department of Pharmacy Newsletter Volume IX, No. III May/June 2006.
  • FDA updates label for stop smoking drug Chantix (varenicline) to include potential alcohol interaction, rare risk of seizures, and studies of side effects on mood, behavior, or thinking. Accessed 4/20/2015.
  • Nicotine Replacement Therapy Labels to Change. Pharmacist’s Letter/Prescriber’s Letter. June 2013-No. 290602
  • Le Houeze J, Aubin HJ. Pharmacotherapies and harm-reduction options for the treatment of tobacco dependence. Expert Opin Pharmacother 2013;14(14):1959-67.
  • Early smoking reduction or cessation by means of no nicotine electronic cigarette added to standard counseling. Accessed 4/20/2015.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy