What is this medicine?
CHLORPHENIRAMINE; GUAIFENESIN; HYDROCODONE; PSEUDOEPHEDRINE (klor fen IR a meen; gwye FEN e sin; hye droe KOE done; soo doe e FED rin) is a combination of an antihistamine, an expectorant, a cough suppressant, and a decongestant. It is used to treat the cough and congestion of colds and other respiratory infections. This medicine will not treat an infection.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): DroTuss, ZTuss Expectorant
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- drug abuse or addiction
- heart disease
- high blood pressure
- if you have taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
- kidney disease
- liver disease
- lung or breathing disease, like asthma
- recent head injury
- stomach problems
- trouble passing urine
- an unusual or allergic reaction to chlorpheniramine, codeine, guaifenesin, hydrocodone, pseudoephedrine, other medicines, foods, dyes or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?
Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
- MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
- stimulant medicines for attention disorders, weight loss, or to stay awake
This medicine may also interact with the following medications:
- antihistamines for allergy, cough, and cold
- barbiturates like phenobarbital
- certain medicines for bladder problems like oxybutynin, tolterodine
- certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
- certain medicines for stomach problems like dicyclomine, hyoscyamine
- certain medicines for travel sickness like scopolamine
- medicines for blood pressure
- medicines for depression, anxiety, or psychotic disturbances
- medicines for sleep
- muscle relaxants
- narcotic medicines (opiates) for pain
- phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Tell your doctor or health care professional if your symptoms do not start to get better in 5 days, if they get worse, or if you have a high fever.
Use exactly as directed by your doctor or health care professional. Do not take more than the recommended dose. You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse.
Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a nonmedical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- changes in vision
- fast, irregular heartbeat
- fear, anxiety, or restless
- feeling faint or lightheaded, falls
- high or low blood pressure
- trouble passing urine or change in the amount of urine
- unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- dry mouth, nose, or throat
- increased sensitivity to sunlight
- loss of appetite
- nausea, vomiting
- trouble sleeping
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.
This medicine may cause accidental overdose and death if taken by other adults, children, or pets. Mix any unused medicine with a substance like cat littler or coffee grounds. Then throw the medicine away in a sealed container like a sealed bag or a coffee can with a lid. Do not use the medicine after the expiration date.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Keep container tightly closed.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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