What is this medicine?
PAPAIN; UREA (puh PAHY in; yoo REE uh) is a debriding agent. It is used on wounds to remove dead tissue and improve healing.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Accuzyme, AllanEnzyme, AllanZyme 650, Ethezyme, Ethezyme-650, Ethezyme-830, Gladase, Kovia, Paptase
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- an unusual or allergic reaction to papain, urea, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?
This medicine is for external use only. Follow the directions on the prescription label. Wash your hands before and after use. Before using this medicine, clean the wound as directed by your doctor or health care professional. Do not use hydrogen peroxide. Apply the ointment directly to the wound, cover with an appropriate dressing, and secure into place. If possible, change the dressing 1 to 2 times per day. Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water. Do not use your medicine more often than directed. Finish the full course of medicine prescribed by your doctor or health care professional even if you think your condition is better.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What may interact with this medicine?
- hydrogen peroxide
- medicines that contain heavy metals such as lead, silver and mercury
Do not use any other medicines on the treated area without asking your doctor or health care professional.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. The drainage from the wound may cause irritation. You may need to change your dressing more frequently until the drainage stops. This will help to soothe the irritation.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- continued swelling, burning, itching, stinging, or pain
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- burning after using ointment
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store in a cool place between 8 and 15 degrees C (46 and 59 degrees F) or refrigerated between 2 and 8 degrees C (36 and 46 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy