What is the prognosis for individuals with persistent depressive disorder?

The outlook for individuals with persistent depressive disorder varies. Classified as a form of chronic depression, persistent depressive disorder can last for several years. Although complete recovery is possible, some individuals may continue to experience symptoms despite pharmacotherapy and/or psychotherapy treatment.

Last reviewed by a Cleveland Clinic medical professional on 03/05/2015.


  • American Psychiatric Association. (2103). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
  • Anxiety and Depression Association of America. Depression Accessed 2/15/2015
  • National Institute of Mental Health. What is Depression? Accessed 2/15/2015
  • Kriston, L., von Wolff, A., Westphal, A., Hölzel, L. P. and Härter, M. (2014), Efficacy and Acceptability of Acute Treatments for Persistent Depressive Disorder: A Network Meta-Analysis. Depress. Anxiety, 31: 621–630. doi: 10.1002/da.22236

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