How can I protect myself from syphilis?

  • Do not have sex with someone who has an open sore on his or her sex organs or whom you know to be infected.
  • Always use a condom during sex. Also use a spermicide that contains nonoxynol-9.
  • Limit your number of sex partners.

Last reviewed by a Cleveland Clinic medical professional on 04/14/2015.


  • Centers for Disease Control and Prevention. Syphilis Accessed 5/8/2015.
  • Augenbraun M. Chapter 19. Syphilis. In: Klausner JD, Hook EW, III. eds. CURRENT Diagnosis & Treatment of Sexually Transmitted Diseases. New York, NY: McGraw-Hill; 2007. Accessed 5/8/2015.
  • National Institute of Allergy and Infectious Disease. Syphilis Accessed 5/8/2015.

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