Nongonococcal urethritis (NGU), sometimes called nonspecific urethritis (NSU), is an infection of the urethra (the tube leading from the urinary bladder to outside the body). The symptoms of NGU are similar to gonorrhea, but the usual treatments for gonorrhea will not work.
NGU is a sexually transmitted infection (STI). It is passed from one person to another by unprotected sexual contact. It can be spread through vaginal sex, oral sex, or anal sex.
NGU is caused by a bacterium called Chlamydia trachomatis. There are several other bacteria—including Ureaplasma urealyticum, _Mycoplasma, _and Trichomonas—that can cause symptoms similar to those of NGU.
It usually takes one to three weeks after the infection occurs before a man develops any symptoms of NGU. The first symptom is usually a leakage of milky fluid (discharge) from the tip of the penis. The amount of discharge may vary from a little to quite a lot. There also may be mild burning in the penis during urination. If the symptoms are ignored, the discharge may decrease although the infection is still present. Sometimes there are no symptoms.
If the infection is not treated, it may move up around the testicles, causing pain, swelling, and sterility. The infection also may spread to other parts of the body, causing severe illness. A similar infection can occur in females and potentially lead to pelvic inflammatory disease (severe infection in the pelvis and reproductive organs) and sterility.
If you think you have NGU, or any STI, contact your health care provider. He or she will examine you and perform tests, if necessary. A sample of fluid is taken from the penis and tested for the germs that cause gonorrhea and chlamydia. (Notably, 20% of men with gonorrhea are also infected with chlamydia.) Testing for HIV and other STIs should also be done in confirmed cases of NGU because they can be acquired at the same time, or may already be present.
NGU is usually treated with antibiotics, which kill the germs that are causing the infection. The antibiotics most commonly used to treat NGU are doxycycline, which is taken twice a day for a week, or macrolide antibiotics, such as azithromycin, given as a single dose. This treatment cures the infection about 90% of the time. If you are allergic to doxycycline, or if doxycycline does not cure your infection, other medicines may be used.
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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or healthcare provider. Please consult your healthcare provider for advice about a specific medical condition. This document was last reviewed on: 03/01/2017