What are the treatments for common variable immunodeficiency (CVID)?

If a diagnosis of CVID is made, a doctor will prescribe immunoglobulin (IgG) replacement therapy to try to prevent infections. People who need IgG therapy have it throughout their whole lives — it’s not a one-time treatment.

IgG therapy replaces your missing immunoglobulin with antibodies from the blood of a pool of healthy donors. You’ll receive this treatment intravenously (through a needle inserted into the vein) or by an injection under the skin (subcutaneous).

Your doctor may also prescribe medications called antibiotics to treat infections related to CVID, and other medications to manage complications of CVID.

What are the complications associated with common variable immunodeficiency (CVID)?

People with CVID have an increased risk of developing complications including:

  • Autoimmune disorders: Conditions where the body’s immune system harms its own cells. Some people with CVID develop immune thrombocytopenia (a low level of platelets in the blood) or autoimmune hemolytic anemia (when the body’s immune system destroys red blood cells).
  • Bronchiectasis: Permanent damage to the lungs from recurrent infections.
  • Cancers: Conditions including lymphoma and stomach cancer.
  • Granulomas: Inflamed cells in the skin, lungs, and other organs.

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