Cleveland Clinic Amyloidosis Center

Cleveland Clinic Center for Personalized Genetic Healthcare

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Amyloid Foundation

Amyloidosis Support Groups

Amyloidosis Research Consortium

Cleveland Clinic Appointments: 866.320.4573

Cleveland Clinic Questions: 800.223.227

Glossary of Terms

Amyloid Fibril: A rigid stack of amyloid proteins that build up in the organs.

Amyloidosis: A disease caused by a buildup of abnormally shaped proteins (amyloid proteins) in organs.

Atrial Fibrillation: An irregular heart rhythm.

Biopsy: A small piece of tissue that is removed and examined under a microscope.

Cardiac magnetic resonance imaging (MRI): A scan that creates detailed pictures of the heart and shows how well it is working.

Echocardiogram: An ultrasound of the heart to show how well it is working.

Electrocardiography (EKG): A recording of the heart’s electrical activity.

Proteins: Large molecules that control the structure and function of the body’s tissues and organs.

Technetium Pyrophosphate Scan (TcPYP): A bone scan that can tell if there is ATTR in the heart.

Transthyretin: A protein produced by the liver.

Last reviewed by a Cleveland Clinic medical professional on 06/02/2020.


  • Cleveland Clinic Amyloidosis Center. Accessed 6/2/2020.
  • Donnelly JP, Hanna M. Cardiac amyloidosis: An update on diagnosis and treatment. CCJM 2017;84(12 suppl 3):12-26. Accessed 6/2/2020.
  • The National Kidney and Urologic Diseases Information Clearinghouse: Amyloidosis and Kidney Disease. Accessed 6/2/2020.
  • Amyloidosis Foundation. FAQs. Accessed 6/2/2020.
  • National Organization for Rare Disorders. Amyloidosis. Accessed 6/2/2020.

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