How is MGUS treated?

Most people with MGUS do not need treatment. Your doctor or healthcare provider will monitor your blood M-protein levels every 6 to 12 months. Monitoring M-protein levels allows your doctor to determine if your condition is changing. Doctors and healthcare providers especially watch to see if MGUS develops into another problem, like multiple myeloma.

What complications are associated with monoclonal gammopathy of undetermined significance (MGUS)?

For a small percentage of individuals, MGUS progresses into certain types of blood cancers, including multiple myeloma, certain lymphomas, or a rare condition called amyloidosis. Also, the condition raises the risk of bone loss and bone fractures in some people. In cases where bone loss happens, your doctor or healthcare provider might tell you to take bone strengtheners to improve bone density.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy