How is persistent pulmonary hypertension in the neonate (PPHN) treated?

The treatment of PPHN may include:

  • Use of oxygen.
  • Use of a special ventilator that breathes for the baby at a very fast rate.
  • Blood pressure support, such as giving medicine intravenously (IV or through the vein).
  • Use of nitric oxide, which helps to dilate or open up the pulmonary vasculature (blood vessels in the lungs).
  • Use of a temporary heart-lung bypass, called extracorporeal membrane oxygenation (ECMO), as a rescue therapy.

Last reviewed by a Cleveland Clinic medical professional on 10/01/2019.


  • National Association of Neonatal Nurses. PPHN Parent Info Page.
  • Steinhorn RH. Neonatal pulmonary hypertension. Pediatr Crit Care Med. 2010;11(2 Suppl):S79-84.

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