How is myelofibrosis diagnosed?

Your doctor will perform a physical examination and ask about your medical history, including any symptoms you are experiencing. The doctor will check for signs of an enlarged spleen or anemia.

Diagnostic tests that may be performed include:

  • Complete blood count (CBC): An elevated number of white blood cells and platelets and a lower than normal number of red blood cells may suggest myelofibrosis.
  • Blood tests: Elevated levels of uric acid, bilirubin, and lactic dehydrogenase may mark the presence of myelofibrosis.

Additional tests may be needed to confirm the diagnosis, including

  • Gene mutation analysis: Blood cells may be examined for certain mutations associated with myelofibrosis.
  • Bone marrow biopsy: A sample of bone marrow may be removed for examination under a microscope.
  • Imaging tests: An ultrasound test may be performed to check for enlargement of the spleen.

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