How is sclerosing mesenteritis treated?

Your doctor may prescribe medications to relieve symptoms, but if the sclerosing mesenteritis leads to a bowel blockage, you will need surgery. The medications your doctor may prescribe are glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.

Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs. Cyclophosphamide and thalidomide have also been used, although their success is not well proven.

The medications may take several weeks to work. You may need to take the medication on an ongoing basis because stopping treatment may lead to return of the disease.

Last reviewed by a Cleveland Clinic medical professional on 11/02/2016.


  • Akram S, Pardi DS, Schaffner JA, Smyrk TC. Sclerosing mesenteritis: Clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatol 2007;5:589-596.
  • Bala A, Coderre SP, Johnson DR, Nayak V. Treatment of sclerosing mesenteritis with corticosteroids and azathioprine. Can J Gastroenterol 2001;15:533.

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