How is hypercalcemia treated?

Treatment of hypercalcemia depends on what is causing the disorder and how severe it is. Often the doctor may tell you calcium levels can be lowered if you:

  • Drink more water
  • Switch to a non-thiazide diuretic or blood pressure medicine
  • Stop calcium-rich antacid tablets
  • Stop calcium supplements

If the hypercalcemia is due to an overactive parathyroid gland, your doctor can consider several options:

  • Close monitoring of the calcium level
  • Referral to surgery to have the overactive gland(s) removed
  • Starting a medication such as cinacalcet (Sensipar®), which is used to manage hypercalcemia
  • Using bisphosphonates, osteoporosis drugs given intravenously (with a needle through the veins) that treat hypercalcemia due to cancer
  • Using denosumab (XGEVA®), another bone-strengthening drug for patients with cancer-caused hypercalcemia who don’t respond to bisphosphonates

If the hypercalcemia is severe, and/or causing significant symptoms, your doctor may recommend immediate hospitalization for intravenous fluids and other treatments.

Last reviewed by a Cleveland Clinic medical professional on 07/02/2018.


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