How is mononucleosis treated?

There are no medications that can treat mononucleosis, because antibiotics and antiviral drugs are not effective against the virus. If you are diagnosed with mononucleosis, here are some suggestions for how to deal with it:

  • Get lots of rest, preferably bed rest, especially the first week or two.
  • Drink plenty of water and other fluids.
  • Take nonprescription pain relievers, such as ibuprofen (or
    acetaminophen, if you cannot take ibuprofen) to help relieve the fever and
    muscle aches that are common symptoms.
  • To help soothe a painful sore throat, use throat lozenges, drink cold
    beverages, or eat frozen desserts, such as popsicles.
  • Gargle with salt water several times a day if your throat feels sore.
    Prepare the salt water solution by dissolving about one-half teaspoon of
    salt in 8 ounces of warm water.
  • Avoid any strenuous physical activity, such as exercise, heavy lifting, or contact sports, for at least 4 to 6 weeks after being diagnosed with mononucleosis. This is to prevent rupture of the spleen, which is fragile during mononucleosis.

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