How is Behçet's disease treated?

Different drugs are used to treat Behçet's disease, depending on how severe the illness is:

  • Corticosteroids, such as prednisone, are the main treatment. These drugs suppress inflammation and immune function.
  • Colchicine (Colcrys) may help with mouth and genital sores.
  • Other drugs that suppress the immune system, such as: methotrexate (Trexall, Rasuvo), azathioprine (Imuran, Azasan), and cyclophosphamide (Cytoxan, Neosar); and anti-TNF biologics, such as infliximab (Remicade) and etanercept (Enbrel), are useful in more severe cases.
  • Recently, Apremilast (Otezla), an oral medication (taken by mouth), was found to be effective in controlling mouth ulcers in Behçet's disease.

Last reviewed by a Cleveland Clinic medical professional on 02/21/2017.


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