How is ulcerative colitis treated?

Treatment can include drug therapy, dietary modifications and/or surgery. Though treatments cannot cure ulcerative colitis, they can help most people lead normal lives.

It is important for you to seek treatment as soon as you start having symptoms. If you have severe diarrhea and bleeding, hospitalization may be necessary to prevent or treat dehydration, reduce your symptoms and ensure that you receive proper nutrition.


Several medications, including 5-aminosalicylic drugs, corticosteroids, immunosuppressive agents and antibiotics, are used to reduce inflammation of the bowel tissue, allowing it to heal and relieve symptoms.

  • 5-aminosalicylic acid (5-ASA): Sulfasalazine is one of the treatments for ulcerative colitis. Let your doctor know if you are allergic to sulfa before taking this medication since it contains sulfa. He or she can prescribe a sulfa-free 5-ASA.
  • Corticosteroids: Anti-inflammatory medications can be used when 5-ASA is ineffective. Corticosteroids are also used to treat people who have more severe disease. The use of corticosteroids is limited by side effects and the potential of long-term complications. In general, corticosteroids are used for short periods of time to cause remission. Remission is maintained with a 5-ASA medication.
  • Immunosuppressants: If corticosteroids or 5-ASA are not effective, immunosuppressants, such as 6-mercaptopurine (6-MP), or azathioprine may be prescribed.
  • Biologic agents: Infliximab (Remicade®) is a monoclonal antibody directed against tumor necrosis factor. It is used in ulcerative colitis patients to treat those with severely active disease. Other biologic agents available for ulcerative colitis patients are Humira®, Simponi®, and Entyvio®.


For mild to moderate ulcerative colitis, your doctor or dietitian may recommend a diet high in protein and calories and low in fiber.


Surgery, in which the entire colon is removed, may be necessary when medications are not effective or if you have severe complications of the disease.

Surgery to remove the entire large intestine (colectomy),or both the colon and rectum (proctocolectomy) removes the threat of colon cancer.

If the entire colon is removed, the operation may create an opening, or stoma, in the abdominal wall, to which a bag is attached (ileostomy). The tip of the lower small intestine is brought through the stoma. Stools pass through this opening and collect in an external pouch, which is attached to the stoma and must be worn at all times.

The pelvic pouch, or ileal pouch-anal anastomosis (IPAA), is a procedure that does not require a permanent stoma. In this procedure, the colon and rectum are removed, and the small intestine is used to form an internal pouch or reservoir that will serve as a new rectum. This pouch is connected to the anus. The reservoir is called a J-pouch. This procedure is frequently done in two to three operations and requires a temporary ileostomy in between.

The continent ileostomy (Kock pouch) is an option for people who would like their old-style ileostomy converted to an internal pouch and for people who don't qualify for the IPAA procedures. In this procedure, there is a stoma but no bag. The colon and rectum are removed, and an internal reservoir is created from the small intestine. An opening is made in the abdominal wall, and the reservoir is then joined to the skin with a nipple valve. To drain the pouch, you insert a catheter through the valve into the internal reservoir.

If you have been told you need surgery to treat ulcerative colitis, you may want to seek a second opinion to ensure the treatment prescribed is the most appropriate. Make sure your diagnosis is confirmed by experts at an institution experienced in identifying and treating digestive disorders.

Last reviewed by a Cleveland Clinic medical professional on 03/20/2016.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy