Graft vs Host Disease: An Overview in Bone Marrow Transplant: Prevention
How can graft versus host disease prevented?
Tissue typing labs have been developing and using more precise DNA level tests to enable your BMT Team to select the best HLA matched donor for you.
We try to lower your risk of developing GvHD by giving you preventive (prophylactic) immunosuppressive medicines after your transplant. These medicines will decrease the ability of your donor's T cells to start an immune response against your own tissues.
Fungal, bacterial, and viral infections are major risks with this prophylactic medicine regimen, since your immune system will be suppressed and have a decreased ability to fight infection.
New, and hopefully better, methods to prevent GvHD are being studied in clinical trials. The use of photopheresis, different immunosuppressive drugs, and new monoclonal antibodies given to recipients after transplant, as well as methods to remove donor T cells prior to transplant, are examples of some of that research.