Most breast cancers (about 95 percent) develop in specialized cells called epithelial cells that line the milk ducts of the breast. Each breast has 6 to 9 separate ducts, which function independently of each other. Cancer that begins in one duct may be contained to that duct if caught early, making treatment more effective and increasing survival. By the time cancer is detected, however, it often has progressed beyond a single duct. (Experts estimate that it takes 8 to 10 years for cancer to grow from 1 cell to a mass large enough to be detected on a mammogram—about 1 billion cells.) Current research is seeking ways to identify women at highest risk for breast cancer so that proactive risk management may be started to help prevent the development of breast cancer.

What is ductal lavage?

Ductal lavage is a procedure for collecting cells from the milk ducts of the breast for analysis. The procedure is used to identify cells in a pre-cancer stage, called atypical cells. Ductal lavage currently is performed on women who have multiple risk factors for breast cancer. (A risk factor is a condition or behavior that puts a person at risk for developing a disease.)

Ductal lavage is a minimally invasive procedure that may be performed in a doctor’s office or outpatient center. It is performed in three steps:

  • Step 1 — An anesthetic cream is applied to numb the nipple area. Gentle suction is used to withdraw a small amount of fluid from the milk ducts. This is done to locate the opening of the ducts on the nipple’s surface and to identify ducts to be tested. Ducts that do not produce fluid generally are not tested with the lavage procedure, since atypical cells are more commonly found in ducts that produce fluid.
  • Step 2 — A hair-thin catheter (small tube) is inserted into the natural opening of the duct. Additional anesthetic is delivered into the duct. A saline (salt and water) solution is then infused through the catheter to rinse the duct, which loosens cells from the duct lining. The solution containing the loosened cells is withdrawn through the catheter. (The word "lavage" is French for "wash" or "rinse.")
  • Step 3 — The sample is sent to the laboratory for analysis to determine if the cells are normal or abnormal (atypical cells). Women with atypical cells have an increased risk of developing breast cancer.

Who is a candidate for ductal lavage?

Ductal lavage is recommended only for women who are at high risk for breast cancer. There are several factors that put a woman at high risk for developing breast cancer, including:

  • A personal history of breast cancer
  • A family history of breast cancer, particularly in a mother, daughter or sister
  • Evidence of a specific gene (BRCA1/BRCA2 mutation)
  • A Gail Index score of at least 1.7 percent (The Gail Index uses risk factors such as age, family history of breast cancer, age of first menstrual period and first pregnancy, and number of breast biopsies to calculate a woman’s risk of developing breast cancer within the next five years.)

What happens if atypical cells are found?

Not all atypical cells are destined to become cancer; they are cells that have begun to change and are at risk of becoming cancerous. Knowing that you have atypical cells can help you and your doctor plan a strategy to reduce your risk of developing breast cancer. A risk management strategy may include:

  • Increased breast health monitoring, such as more frequent clinical breast exams
  • Medication, such as tamoxifen, that lowers breast cancer risk
  • Surgery such as prophylactic mastectomy (surgery to remove a breast before cancer develops)

What will I feel during the procedure?

Most women do not find the procedure to be painful, saying it is no more uncomfortable than a mammogram. You may feel temporary sensations such as fullness, pinching and tingling in the breast. However, numbing medications (anesthetics) are used to help reduce discomfort during the procedure.

Is ductal lavage used instead of a mammogram?

No. Ductal lavage is used as an adjunct, or addition, to regular breast health practices—such as breast self-exams, annual clinical exams and mammography—not in place of these screening tools. In addition, ductal lavage is not recommended for women with a low risk for breast cancer.

What risks are associated with this procedure?

There are few risks associated with ductal lavage. Rarely, an infection may develop at the site of the catheter insertion. It is possible to perforate, or puncture, the milk duct, although perforation is rare and generally causes no permanent damage to the breast.

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This information is provided by the Cleveland Clinic and is not intended to replace the medical advice of your doctor or health care provider. Please consult your health care provider for advice about a specific medical condition. This document was last reviewed on: 1/2/2008…#10741