Chronic Variable Immunodeficiency: Percentage of CVID patients who meet diagnostic, evaluation and treatment guidelines (2015-2019)

Percentage of CVID Patients Who Meet Diagnostic, Evaluation, and Treatment Guidelines (2015-2019)


CT = computed tomography, CVID = common variable immunodeficiency, IgA = immunoglobulin A, IgG = immunoglobulin G, IgM = immunoglobulin M, LFT = liver function test, PFT = pulmonary function testing

¹ Immune Deficiency Foundation Diagnostic & Clinical Care Guidelines
for Primary Immunodeficiency Diseases. Buckley et al. IDF Foundation

² How I treat common variable immune deficiency. Cunningham-Rundles
Blood. 2010 Jul 8;116(1):7-15. Carsetti R, Rosado MM, Donnanno S, et al.

³ The loss of IgM memory B cells correlates with clinical disease in common
variable immunodeficiency. J Allergy Clin Immunol. 2005;115(2):412-417.

It is recommended that patients with Common Variable Immunodeficiency have baseline response to multiple vaccines as well as evaluation of B cell subsets at the time of diagnosis.³ Spirometry or a CT scan of the chest, IgG level, liver function tests, and creatinine levels are recommended as yearly follow-up testing. These guidelines are based on expert panel recommendations formulated through the Immune Deficiency Foundation as well as published recommendations of experts in the field.¹,² B cell subsets are recommended in the initial lab testing due to recent publications indicating their value in predicting future clinical course.³

Statistics and outcome measures were gathered from EPIC and local EMR records for patient visits in 2019.