Details

IRB Study Number 17-976

Status Not yet recruiting

Location Cleveland Clinic Main Campus

Institute Neurological Institute

Description

Description

The study will conduct validation and assess the utility of the central neurological exam (EDSS, MSFC, 25-foot walk, 9-Hole Peg test, and visual contrast sensitivity test) and undergo an MRI. The study visit will take approximately 2 hours. Participants will receive a parking voucher after their visit is completed.

Inclusion Criteria

Inclusion Criteria

  • Age 18 to 65 inclusive
  • Referral to the academic site for a new clinical or radiological suspicion of multiple sclerosis
  • Not on disease modifying therapy for multiple sclerosis
  • Cranial MRI scan demonstrating T2-hyperintensities
  • Able to provide writen informed consent to participate in the study

Exclusion Criteria

Exclusion Criteria

  • Contraindication to MRI studies, metal or metal implants incompatible with MRI
  • Not be able to tolerate MRI due to claustrophobia or excessive movement related to tremor
  • Contraindication to use of gadolinium contraining contrasts agents (allergy or renal failure)
  • Treatment with systemic corticosteroids in the 4 weeks preceding enrollment