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Ulf Knothe, MD


Ulf Knothe, MD
Department: Orthopaedic Surgery
Location: Cleveland Clinic Main Campus
Mail Code A41
9500 Euclid Avenue
Cleveland, OH 44195
Ulf Knothe, MD
Department: Orthopaedic Surgery
Location: Euclid Medical Office
Mail Code A41
99 Northline Circle
Euclid, OH 44119
Adults Only

Biographical Sketch

Ulf Knothe, MD, specializes in adult reconstruction, particularly hip and knee replacement. He joined Cleveland Clinic in 2002. His specialty interests include adult reconstructive surgery, hip and knee replacement, orthopaedic research and development of new treatments and prophylactic measures for bone diseases such as osteoporosis (bone loss) and osteonecrosis as well as reconstruction procedures associated with osteoarthritis and musculoskeletal oncology.
As an active clinician and researcher, Dr. Knothe has developed new implants and instrumentation, as well as innovative orthopaedic surgical procedures. His basic research focuses on new treatments for bone diseases, such as osteoporosis, implant loosening and fracture healing. He is investigating a treatment to prevent bone loss in space with support from NASA.

Dr. Knothe has presented his development and research work at local, national and international conferences, and he is well-published. He is a member of the American Medical Association, the International Society for Technology in Arthroplasty and the Orthopaedic Research Society.

Professional Highlights

  • Internationally trained at top U.S. and European orthopaedic centers
  • Active in research and development of state of the art and cutting edge implants and surgical procedures
  • Collaboration with leading biomedical research groups and translation of newly developed technologies in the United States and abroad
  • Extensive experience in trauma and reconstructive orthopaedic procedures, including revision of joint replacement surgeries

Education & Fellowships

Fellowship - Cleveland Clinic
Orthopaedic Surgery
Cleveland, OH USA
Fellowship - The Mount Sinai School of Medicine
Orthopaedic Research
New York, NY USA
Doctorate - University of Bern Faculty of Medicine
Bern Switzerland
Residency - Hospital Centre Biel/Bienne
Ortho Surgery/Hand Surgery
Residency - Inselspital University Hospital Bern, Switzerland
Ortho Surgery/Hand Surgery
Bern Switzerland
Residency - University of Bern/AO ASIF Research Institute
Implant Development
Davos Switzerland
Internship - Regional Hospital
General Surgery
Interlaken Switzerland
Medical School - University of Bern Faculty of Medicine
Bern Switzerland
Graduate - Gymnasium Biel/Bienne


  • Swiss Medical Association- Orthopaedic Surgery

Specialty Interests

Hip and knee replacement and revision surgery, knee arthroscopy, hip and knee total joint replacement revisions and infections, hip resurfacing

Awards & Honors

Wallace  H. Coulter Award for Innovation and Entrepreneurship. Semi-Finalist, 8/2002

Additional Training

  • Birmingham Hip Resurfacing Procedure training, 2007
  • Human Subjects Research Training, Collaborative Institutional Review Board Training
  • Initiative Human Subjects Research Training Program, 2007
  • Educational Commission for Foreign Medical Graduates, Steps 1-3, Clinical Skills Assessment, 2000-2001

Innovations & Patents

  • Preliminary patent application, “BonePrimer” Technology, February 20, 2002
  • IISIS, Intraoperative In Situ Imaging System, preliminary disclosure, April 2002
  • Full Utility Patent Application for “BonePrimer” technology: Composition and Method for Inducing Bone Growth and Healing,  February 20, 2003


  • American Medical Association
  • Ohio State Medical Association
  • International Society for Technology in Arthroplasty
  • American Society for Cell Biology 

Treatment & Services

  • Arthritis Surgery
  • Arthroplasty
  • Birmingham Resurfacing Procedure of the Hip
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Core Decompression Surgery
  • Fracture Non-union
  • Fracture Reconstruction
  • Hip & Knee Surgery
  • Hip Replacement
  • Hip Resurfacing
  • Hip Revision
  • Joint Aspiration
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroscopy
  • Knee Revision
  • Knee Surgery
  • Minimally Invasive Surgery
  • Orthopaedic Surgery
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Resurfacing Total Hip Arthroplasty
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Shock Wave Treatment
  • Therapeutic Injections
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
  • Total Knee Replacement
  • Viscosupplementation

Specialty in Diseases and Conditions

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. The Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, the Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/23/2014, Dr. Knothe has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers’ discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Languages Spoken

  • English
  • French
  • German