George Muschler, M.D.
| Appointed: |
1988 |
| Gender: |
Male |
| Languages: |
English |
Orthopaedic Surgery
Transplantation Center
Taussig Cancer Institute
Biomedical Engineering
Biographical Sketch
George Muschler, MD, joined the Department of Orthopaedic Surgery in 1988. Since his arrival, he has developed a regional and national reputation in reconstructive surgery for arthritis, failed joint replacements, treatment of fractures that have failed to heal and treatment of limb deformities. He is recognized and appreciated internationally as a leader in skeletal reconstruction, bone regeneration and fracture repair. In 1999, he was appointed Research Associate in the Cleveland Clinic Office of Clinical Effectiveness, due to his work in establishing a program of patient-oriented outcomes assessment for hip and knee replacements performed in the Department of Orthopaedic Surgery. Dr. Muschler is also a member of Cleveland Clinic Taussig Cancer Center, leading and collaborating in research related to aging and adult stem cell therapies and transplantation.
In addition to his commitment to patient care, Dr. Muschler is a Vice-Chairman of the Department of Biomedical Engineering within the Cleveland Clinic's Lerner Research Institute. There he directs the Bone Biology Laboratory. This laboratory is supported by the National Institutes of Health and other funding agencies, and is focused on development of improved methods for tissue engineering and regenerative medicine. This work has provided insight into the effects of aging on stem cells of bone and cartilage, and the importance and application of these cells in development of osteoporosis, bone diseases and in the broader area of tissue repair, including bone, cartilage, tendon, nerve, muscle and skin.
Dr. Muschler has become a leader in the development of collaborative interdisciplinary programs and research teams in the area of tissue engineering and regenerative medicine, contributing significantly to both regional and national development of translational research leading to new products and therapeutic strategies. In 2005, he and colleagues at Cleveland Clinic, Case Western Reserve University, University Hospitals, NASA Glenn Research Center and the Ohio Super Computer Center established the Clinical Tissue Engineering Center (CTEC), through a grant from the Ohio Third Frontier Program. CTEC continues to serve as a catalyst for research and collaboration in the development and assessment of new therapies between over 70 Ohio investigators and over 10 Ohio institutions.
Dr. Muschler and CTEC participate in the National Center for Regenerative Medicine (NCRM), a collaboration between Cleveland Clinic and Case Western Reserve University, where he serves in the Executive Committee.
Since 2007, Dr. Muschler has served as Vice Chairman of the Orthopaedic and Rheumatologic Institute at the Cleveland Clinic, focusing efforts in the area of Research and Clinical Quality Assessment and Management.
In 2007, Dr. Muschler became Co-Director of the Armed Forces Institute for Regenerative Medicine (AFIRM), which is now an integrated national network of leading scientists and clinicians at 28 other institutions dedicated to developing new methods for treating battlefield injuries sustained by US service members.
Professional Highlights
- Director, Orthopaedic and Rheumatologic Research Center, 2005-Present
- Director, Clinical Tissue Engineering Center (CTEC), 2005-Present
- Vice Chairman, Department of Biomedical Engineering, 2004-Present
- Vice Chairman for Research, Cleveland Clinic Orthopaedic and Rheumatologic Institute, 2007-Present
- Co-Director, Armed Forces Institute for Regenerative Medicine (AFIRM), 2007-Present
Education & Fellowships
| Medical School: | Northwestern University Feinberg School of Medicine, Chicago, IL |
|
| Internship: | University of Texas Southwestern Medical Center at Dallas, Surgical Internship, Dallas, TX |
| Residency: | University of Texas Southwestern Medical Center at Dallas, Orthopedic Surgery, Dallas, TX |
| Fellowship: | Hospital for Special Surgery, Orthopaedic Surgery, New York, NY |
| Fellowship: | Memorial Sloan-Kettering Cancer Center, Musculoskeletal Oncology, New York, NY |
| Other Education: | (Undergraduate) University of Illinois at Urbana-Champaign, Urbana, IL |
Certifications
Specialty Interests
Arthritis surgery, joint replacement of the hip and knee, Treatment Of Fracture Non-union.
Innovations & Patents
- Innovator in both implant design for joint surgery and limb reconstruction, as well as in the application of biological principles to the regeneration of new tissues, particularly bone.
- Responsible for over nine patents and recognized as inventor of the concept of selective retention as a means of rapidly concentrating and delivering a patient's own stem cells for use in tissue-healing applications. This is the basis for the Cellect TM Device, that has now been used in treatment of over 50,000 patients worldwide for bone repair following spine surgery or fractures.
Awards & Honors
- North American Traveling Fellowship, American Orthopaedic Association, 1989
- Career Development Award, Orthopaedic Research and Education Foundation, 1990-1992
- J.P Ranney Award for Innovation in Regenerative Medicine and Stem Cell Research, 2006
- Clevelands Best Doctors, Northern Ohio Live magazine, 2007
Professional Memberships
- American Academy of Orthopaedic Surgeons
- Orthopaedic Research Society
- American Orthopaedic Association
- Association of Bone and Joint Surgeons
- International Society for Tissue Engineering
- International Society for Stem Cell Research
- American Society for Bone and Mineral Research
Specializes in Diseases and Conditions
Specializes in Services
Industry Relationships
Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical education about recent trends. The collaborations are reviewed as part of the Cleveland Clinic’s procedures. The Cleveland Clinic publicly discloses payments to its physicians and scientists for speaking and consulting of $5,000 or more per year, and any equity, royalties, and fiduciary relationships in companies with which they collaborate. In publicly disclosing this information, the Cleveland Clinic tries to provide information as accurately as possible about its doctors’ connections with industry and those of their immediate family members. As of 9/7/2008, Dr. Muschler has reported the financial relationships with the companies listed below. Patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by the Cleveland Clinic. To learn more about the Cleveland Clinic’s policies on collaborations with industry and innovation management, go to our
Integrity in Innovation page.
Royalty Payments. Dr. Muschler has the right to receive royalty payments for inventions or discoveries related to the companies shown below:
Fiduciary Role. Dr. Muschler serves in a fiduciary capacity, such as an officer or director, for the following companies or other entities:
- Orthopaedic Research Society
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