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About Transplant Center

Cleveland Clinic's Transplant Center provides the highest quality of transplantation procedures. These life-transforming surgeries take place everyday here in the hands of our experts.

At Cleveland Clinic's Transplant Center, world-class experts perform a variety of transplantation procedures. Each year, thousands of lives are saved and transformed because of our innovative transplant expertise. Combining quality, excellence and the top transplant physicians and specialists, Cleveland Clinic Transplant Center is proud to be a leader in organ transplantation. We offer one of the most comprehensive transplant programs in the world and perform a variety of transplantations including:

In 2011, Transplant Center staff completed more than 600 organ and bone marrow transplants, including nine pediatric transplants, and used approximately 6,500 tissue segments in surgical reconstruction. All of our efforts are aimed at helping our patients live the healthiest lives possible and to make organ transplantation more widely available to victims of disease and traumatic injury.

The Center is led by Director Kareem Abu-Elmagd, MD, PhD. Dr. Abu-Elmagd led the Intestinal Rehabilitation and Transplant Center at the University of Pittsburgh Medical Center (UPMC) since its establishment in 1999 and earned an international reputation for clinical and technical contributions to the field of transplantation since then. He is an active member of 13 prominent professional and scientific societies, and is the current president of the Intestinal Transplantation Association.

Cleveland Clinic's Transplant Center participates in numerous scholarly training and teaching opportunities each year resulting in staff publications, lectures and abstracts. These opportunities include the work of medical students, Lifebanc employees, transplant coordinators, medical technologist students, other Cleveland Clinic residents and fellows and more.

The Transplant Center works closely with Lifebanc, Northeast Ohio's federally designated, nonprofit organ procurement organization (OPO). Increasing organ and tissue donation for those awaiting transplant is one of Lifebanc's main goals. Working with more than 80 hospitals, Lifebanc is responsible for all aspects of the organ and tissue recovery and donation processes, public and professional education programs, and bereavement services for donor families. Lifebanc is a member of the United Network of Organ Sharing (UNOS) and an accredited member of the Association of Organ Procurement Organizations (AOPO) and the American Association of Tissue Banks (AATB).

2013 Allogen Laboratories Report

Allogen Laboratories is a wholly owned subsidiary of the Cleveland Clinic Foundation, and performs testing and validation studies for different Cleveland Clinic institutes and centers.

Training
  • Transfusion Medicine CCF: 2 fellows
  • City Wide Transfusion Medicine: 1 fellow
  • International Observers/visitors: 5 observers
  • Metro Pathology Residents: 4 residents
  • Others: 22 including medical students, CCF residents and fellows, Lifebanc employees, transplant coordinators, medical technologist students, etc.
Teaching
  • Immunology block, first year medical curriculum, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University (2008 – present)
  • Invited Lectures (2013 only)
International

The GPS for Transplant Immunologic Risk Assessment: The 25th Congress of The Southern African Transplantation Society. Durban, South Africa, July 29- Aug. 2, 2013

Tissue Typing: Laboratory Requirements for Transplantation: The Global Alliance for Transplantation (GAT) Workshop. Durban, South Africa, July 29-30, 2013

Innovative Approaches To Induce Immunologic Tolerance in Face and Limb transplantation: Cairo University CLINCHEM Meeting: Is Regenerative Medicine a hope or hype? Cairo, Egypt, April 28-29, 2013

Clinical Implications Of HLA Antibodies In Thoracic Organ Transplantation: The Saudi International Congress on New Frontiers in Organ Transplantation. Riyadh, Saudi Arabia, March 4-7, 2013

Flow Cytometric Crossmatch: Technical Considerations and Clinical Relevance in the Context of Transplant Immunologic Risk Assessment: The Saudi International Congress on New Frontiers in Organ Transplantation. Riyadh, Saudi Arabia, March 4-7, 2013

The Concept of The Educational Academy From The Transplantation Society: The Saudi International Congress on New Frontiers in Organ Transplantation. Riyadh, Saudi Arabia, March 4-7, 2013

National

HLA and Transplant Immunology: Clinical Laboratory Immunology Review Course, Association of Medical Laboratory Immunology. Savannah, GA, Aug. 9, 2013

Local

HLA and Immunogenetics: Molecular & Genetic Pathology Fellowship Conference Series, Cleveland Clinic, Cleveland, OH, July 17, 2013

Histocompatibility & Immunogenetics Testing in Heart Transplantation. Advanced Heart Failure Fellowship Lecture Series, Cleveland Clinic, Cleveland, OH, May 16, 2013

Histocompatibility Evaluation and Hematopoietic Stem Cell Transplantation: Principles and Practices.  Allergy Immunology Fellowship Conference, May 15, 2013

Histocompatibility & Immunogenetics Testing: Technology & Applications. Summa Health System Pathology Residency Lecture, Akron, OH, April 17, 2013

HLA Antibodies in Solid Organ Transplantation: Laboratory Assessment and Clinical Relevance. Transplant Center Grand Rounds, Cleveland Clinic, Cleveland, OH, Feb. 11, 2013

Publications (2013 Only): 10 Manuscripts + 21 Abstracts, Peer Reviewed Articles

Askar M, Hsich E, Reville P, Daghstani J, Nowacki A, Zhang A, Klingman L, Bakdash S, Baldwin W, Smedira N, Taylor D, Starling R, Gonzalez-Stawinski G. Comparison of HLA & MICA Allosensitization Patterns among Patients Supported by Ventricular Assist Devices (VAD) and Patients with No Devices. In Submission (Submitted to J Heart Lung Transplant) 2013

van Duin D, Avery R, Hemachandra R, Yen-Lieberman B, Zhang A, Jain A, Butler R, Barnard J, Schold J, Fung J, Askar M. KIR and HLA Interaction Predict CMV viremia in High-Risk Solid Organ Transplant Recipients. In Submission (Submitted to Am J Transplant) 2013

Tiriveedhi V, Gautum B, Sarmaa N, Askar M, Budev M, Aloush A, Hachem R, Trulock E, Meyers B, Patterson A, Mohanakumar T. Pre-transplant antibodies to Kα1Tubulin and CollagenV in lung transplant recipients: Correlation to pre-existing disease, implications for development of primary graft dysfunction, alloimmune responses and chronic rejection. In Submission (Submitted to J Heart Lung Transplant) 2013

Edinur H, Chambers; G, Hammond L, Selwyn C, Brescia P, Askar M, Reville P, Velickovic Z, Lea R and Dunn P. HLA and MICA polymorphism in Polynesians and New Zealand Maori: Implications for ancestry and health. In Submission (Submitted to Human Immunology) 2013

Taimur S, Askar M, Sobecks R, Rybicki L, Warshawsky I, Mossad S. Donor T-cell chimerism and Early Post-transplant Cytomegalovirus Viremia in patients treated with Myeloablative Allogeneic Hematopoietic Stem Cell Transplant. Accepted for publication in Transplant Infectious Diseases 2013

Hurley C, Woolfrey A, Wang T, Haagenson M, Umejiego J, Aljurf M, Askar M, Battiwalla M, Dehn J, Horan J, Oudshoorn M, Pidala J, Saber W, Turner V, Lee S, Spellman S. The Impact of HLA Unidirectional Mismatches on the Outcome of Hematopoietic Stem Cell Transplantation with Unrelated Donors. Blood. 2013 May 1. [Epub ahead of print]

Reville P, Zhao C, Perez T, Nowacki A, Phillips D, Bowen G, Starling N, Strickland R, Fung J, Askar M. A Student Leadership Model for Promoting Educational Programs in Organ Donation and Transplantation. In Press (Accepted for publication in Transplant Proceedings) 2013

Cuellar-Rodriguez J, Poggio E, Mossad S, Goldfarb D, Lard M, Askar M, Fatica R, Stephany B, Srinivas T, Braun W, Shoskes D, Schmitt S, Shrestha R, Avery A. Contrasting Patterns of Viral Load Response in Kidney and Kidney-Pancreas Transplant Recipients with BK Polyomavirus DNAemia on Leflunomide Therapy. Clin Transplant. 2013 Apr 3. doi: 10.1111/ctr.12110. [Epub ahead of print]

Askar M. The Role of Professional Societies in Fostering Leadership and Innovations in Health Care Education: A Preliminary Report on The Education Academy Initiative of The Transplantation Society. Ann Saudi Med. Supp Mar 2013: 62

Askar M, Daghstani J, Thomas D, Leahy N, Dunn P, Claas F, Doran S, Saji H, Kanangat S, Karoichane M, Tambur A, Monos D, El-Khalifa M, Turner V, Kamoun M, Mustafa M, Ramon D, Gandhi M, Vernaza A, Gorodezky C, Wagenknecht D, Gautreaux M, Hajeer A, Kashi Z, Fernandez-Vina M. 16th IHIW: Global distribution of extended HLA haplotypes. Int J Immunogenet. 40(1): 31, 2013

Abstracts

Sobecks R, Zhang A, Rybicki L, Thomas D, Kalaycio M, Andresen S, Pohlman B, Dean R, Duong H, Maciejewski J, Bolwell B and Askar M. The Impact of KIR Genotypes And Ligands On Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplant Patients with AML. Submitted to The 55th ASH Annual Meeting, New Orleans, LA, Dec 7 - 10, 2013

Kane S, Parungao J, Lopez R, Askar M, Zein N. Pathogen recognition receptor polymorphisms and spontaneous bacterial peritonitis in patients undergoing liver transplantation. Submitted to The AASLD - The Liver Meeting, Washington, DC, Nov 1 - 5, 2013

Askar M, Kearns J, McCarro V, Khan S, Klingman L, Flechner S, Fung J and Kamoun K. Complement Fixing Donor-Specific Antibodies Identified By The C1q Assay In Combined Liver-Kidney Transplants With AMR. Submitted to The 39th ASHI Annual Meeting, Chicago, IL, Nov 17-21, 2013

Vernaza A, Moscoso J, Askar M. KIR Haplotype And Genotype Distribution In Hematopoietic Stem Cell Transplant Donors In Panama. Submitted to The 39th ASHI Annual Meeting, Chicago, IL, Nov 17-21, 2013

Vernaza A, Gutierrez Y, Viggiano C, Manzanares J, Cuero C. Askar M. Detection Of MICA Antibodies - In HLA Allosensitized Kidney Transplant Candidates On The Deceased Donor Waiting List In Panama. Submitted to The 39th ASHI Annual Meeting, Chicago, IL, Nov 17-21, 2013

Askar M, Budev M, Klingman L, Zhang A, McCurry K, and Farver C. C4d Staining And Histological Features Of Protocol Lung Biopsies in Patients Who Develop with De Novo Donor HLA Specific Antibodies. Accepted for Presentation in the 12th Banff Conference on Allograft Pathology, Bahia, Brazil, Aug 17-23, 2013

Askar M, Yerian L, Klingman L, Zhang A, Liu X. The Frequency of De Novo Donor HLA Specific Antibodies (DSA) and Their Association with Histological Findings and C4d immunoreactivity in Transplant Liver Biopsies. Accepted for Presentation in the 12th Banff Conference on Allograft Pathology, Bahia, Brazil, Aug 17-23, 2013

Zhang A, Eghtesad B, Miller C, Allen J, Zein N, Tzakis A, Abu Elmagd K, Fung J and Askar M. Multi-Subset Donor Lymphoid Chimerism Patterns during Acute Graft versus Host Disease after Liver Transplant. Accepted for BEST ORAL Presentation in the Joint Meeting of APHIA & HKSHI, Hong Kong, Jul 31 –Aug 2, 2013

Zhang A, Reville P, Dunlap M, Nowacki A, Thomas D, Kawczak P, McMichael J, Sobecks R, and Askar M. Racial Diversity in MICA and Linkage Disequilibrium with HLA-B. Accepted for BEST ORAL Presentation in the Joint Meeting of APHIA & HKSHI, Hong Kong, Jul 31 –Aug 2, 2013

Askar M, Reville P, Daghstani J, Klingman L, McCurry K, and Budev M. Should Repeat HLA mismatches Be Avoided in Lung ReTransplants? Am J Transplant 13 (S5): 159, 2013

Askar M, Reville P, Klingman L, Schold J, Daghstani J, Budev M, McCurry K, and Farver C. Do commonly evaluated Histological finings in Bronchial Biopsies correlate with De Novo DSA after Lung Transplantation? Am J Transplant 13 (S5): 226, 2013

Moussa O, Askar M, and Srinivas T. Proteasome Inhibition and Novel Therapeutic Pathways Targeting Both AMR And Mixed ACR/AMR. Am J Transplant 13 (S5): 535, 2013

Lauterbach N, Voorter C, Rybicki L, Wieten L, Groeneweg M, Sobecks R, Kalaycio M, Tilanus M, Askar M. HLA-E Polymorphism Is An Important Factor In Patient Outcome In Unrelated Hematopoietic Stem Cell Transplantation. Tissue Antigens 81 (5): 291, 2013

Fernandez-Vina M, Setterholm M, Haagenson M, Wang T, Askar M, Woolfrey A, Marsh S, Gandhi M, Lee S, Spellman S. Mismatches For HLA-C*03:03 vs. 03:04 May Be Better Tolerated Than Other Mismatches In Unrelated Donor Hematopoietic Stem Cell Transplantation. Tissue Antigens 81 (5): 292, 2013

Dunn P, Edinur H, Hammond L, Selwyn C, Brescia P, Askar M, Reville P, Velickovic Z, Lea R, Chambers G. High Resolution HLA And MICA Alleles And Haplotypes In Maori And Polynesians Tissue Antigens 81 (5): 368, 2013

A. Aziz N, Edinur H, Dunn P, Hammond L, Selwyn C, Brescia P, Askar M, Reville P, Velickovic Z, Lea R, Chambers G. HLA And MICA Alleles And Haplotypes: Disease Association In Maori And Polynesians. Tissue Antigens 81 (5): 368, 2013

Askar M, Rodriguez R, Reville P, Gatto J, Schold J, Daghstani J, Zhang A, Klingman L, Hsich E, Starling R, Smedira N, Moazami N, Taylor D, Tan C. Predictive Value Of HLA Antibody Characteristics In Progression Of Subclinical Antibody Mediated Rejection In Heart Transplant Recipients. J Heart Lung Transplant 32 (4S): S87, 2013

Askar M, Hsich E, Reville P, Daghstani J, Nowacki A, Zhang A, Klingman L, Bakdash S, Baldwin W, Smedira N, Taylor D, Starling R, Gonzalez-Stawinski G. Comparison of HLA & MICA Allosensitization Patterns Among Patients Supported By Ventricular Assist Devices (VAD) and Patients with No Devices. J Heart Lung Transplant 32 (4S): S74, 2013

Hachem R, Kamoun M, Budev M, Askar M, Ahya V, Levine D, Pollack M, Dhillon G, Schechtman K, Leard L, Baxter-Lowe L, Mohanakumar T, Tyan D, Yusen R. HLA Antibodies after Lung Transplantation: Early Results of the HALT Study. J Heart Lung Transplant 32 (4S): S76, 2013

Tiriveedhi V, Bhaskar G, Sarma N, Askar M, Budev M, Aloush A, Hachem R, Trulock E, Meyers B, Paterson A, and Mohanakumar T. Pre-Transplant Antibodies to Kα1Tubulin and Collagen V in lung transplant recipients: Correlation to disease, implications for development of Primary Graft Dysfunction, Alloimmune responses and chronic rejection. J Heart Lung Transplant 32 (4S): S75, 2013

Zeltzer S, Askar M, McCurry K, and Budev M. HLA Allosensitization in ECMO as a Bridge to Lung Transplantation. J Heart Lung Transplant 32 (4S): S170, 2013

News Archives

2014

Doctor reunites with his patient five years after heart transplant

Cleveland Clinic's Dr. Gerald Boyle is featured.

2013

December

A double cornea transplant gives one woman new sight

Cleveland Clinic's Dr. Allen Roth comments.

Dr. Charles Modlin talks about the importance of organ donation

Man receives transplanted kidney from girlfriend.

Cleveland Clinic physician named to committee that will develop face, hand transplant policies

Dr. John Fung is named to committee.

November

Childhood cancer survivors and Cleveland Clinic heart transplant patients share their stories

Drs. Juan Carlos Plana, Randall Starling and David Taylor comment on two transplant patient's journey.

October

Rocky River woman continues to thrive with Cleveland Clinic’s oldest transplanted kidney

Kidney transplant recipient continues to thrive after receiving a kidney from her mother 45 years ago. Dr. David Goldfarb comments.

Cleveland Clinic caregiver donates kidney to save her daughter and becomes part of second-largest paired kidney exchange

Donors and recipients met up at an event celebrating Cleveland Clinic's 50th anniversary of kidney transplantation.

Cleveland Clinic celebrates fifty years of successful kidney transplants

Dr. Robert Heyka comments on 50 years of kidney transplant experience.

Man receives kidney from friend

Man donates kidney to best friend, Cleveland Clinic physicians performed life saving surgery.

September

Cleveland Clinic researchers study health of living kidney donors following surgery; results are reassuring

Cleveland Clinic researchers find a decline in risks for kidney donors. Jesse Schold, PhD. assistant staff at Cleveland Clinic Lerner Research Institute comments and Cleveland Clinic patients are featured.

Living liver donors can help ease the transplant waiting list

Cleveland Clinic patients and Dr. Federico Aucejo talk about the incredible journey.

July

Stem cell therapy for transplants may end need for long-term immunosuppressive drugs: Discoveries

Cleveland-based Athersys, Inc. is developing stem cell therapies that may free transplant patients from the lifelong use of immunosuppressant drugs. Dr. Kareem Abu-Elmagd, director of the transplantation center at the Cleveland Clinic, discusses his expectations.

Live liver donors could ease U.S. organ shortage crisis, adopted siblings show

Dr. Cristiano Quintini, Cleveland Clinic transplant surgeon, talks about performing live donor transplants and the benefits it can provide to patients searching for options other than the waiting list.

Double lung transplant recipient Michelle Green ready for Progressive Field spotlight

Marie M. Budev, Medical Director of the Lung and Heart Transplant Program at the Cleveland Clinic discusses Green's incredible transplant journey.

June

Rock legend Lou Reed underwent liver transplant at Cleveland Clinic

The heart of rock and roll may be in Cleveland, but Lou Reed came for a liver transplant.

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