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Research & Innovations


MyFamily is a web-based, patient-entered family history disease collection and risk stratification platform which delivers evidence-based, clinically actionable decision support to clinicians at the point-of-care.  Patients who are scheduled for a well-check or annual exam are sent a MyFamily invitation through MyChart to complete a family health history questionnaire prior to visit.  Then, MyFamily uses the information provided by the patient to assess the risk of heritable and genetic diseases.  Finally, clinicians can use the recommendations offered to guide and personalize the care of their patients in the most appropriate and effective way.

Personalized Medication Program

The Personalized Medication Program (PMP) is a program that facilitates the use of genetic information at the point of prescribing medications.  Some genetic markers affect metabolism of medications (also called pharmacogenetics) and can predict the likelihood of having adverse drug events.  PMP alerts clinicians to evidence-based recommendations regarding the use of these genetic markers when prescribing medications and provides them with decision support to aide in ordering and interpreting the tests.  The intended result is improved quality of care with reduction in adverse drug events.  In addition, PMP allows tracking of such pharmacogenetic information and helps to avoid duplicate testing, which results in cost-savings to patients and providers.

Genetics Knowledge & Needs Assessment Survey of Primary Care Physicians at an Academic Medical Center

The overall aim of this study was to assess practicing primary care physicians’ levels of knowledge regarding PHC informed by genetics, genomics, self-efficacy, and educational needs. While the results indicate that there are knowledge gaps among Cleveland Clinic primary care physicians regarding PHC informed by genetics and genomics, the results also indicate that physicians are willing to learn about advanced PHC concepts by attending targeted live educational interventions. In addition, analysis of preference of learning venues for continuing education indicated that approximately 80% of the sample population is interested in conferences, and greater than 80% have no interest in podcasts, newsletters, or mobile applications.

Abdominal Aortic Aneurisms

The aim of this study is to evaluate screening practices for Abdominal Aortic Aneurysm (AAA) in general medicine clinics here at Cleveland Clinic.  AAA is a prevalent disease for which ultrasound screening is available.  We are evaluating screening practices to determine whether our patients are being screened appropriately and which factors are more likely to lead to a referral for screening.  Factors being considered include age, gender, tobacco history, and a family history of AAA.  We are also looking at the outcomes of these screenings in order to evaluate patient characteristics which might be predictive of a positive test.