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SCC 1510 Tissue Source Site Network for The Cancer Genome Atlas Project (TCGA)
- To prospectively collect frozen samples of lung carcinoma as well as adjacent grossly uninvolved lung tissue obtained from surgical tissue specimens of patients with lung cancer to send to TCGA for whole genome sequencing.
- To enhance the availability of archived tissue specimens from patients with prior surgery.
- To collect blood samples from the same patients to provide a source of reference DNA for TCGA.
- To provide de-identified historical, clinical, pathologic and outcome information to the TCGA for each submitted specimen.
Prospective Tissue Collection Participants
- Patient must have suspected or histologically documented lung cancer or mesothelioma. Patients may have a history or prior malignancy provided they meet criteria 3.1.2 and 3.1.6.
- Patient may not have received prior systemic therapy for any malignancy
- Patient must be ≥ 18 years of age.
- Patient must have had or be scheduled to have surgery or biopsy as a matter of standard of care.
- For patients with lung cancer, tumor histology should be either adenocarcinoma or squamous cell carcinoma.
- Patients may not have received radiation therapy to the site where the sample for TCGA submission is located. Patients also may not have received systemic radiation
- Patient must be able to understand and willing to sign an IRB-approved informed consent document.
Retrospective Tissue Collection Participants
- Patients must have met the criteria specified in section 3.1.1-3.1.6 at the time of sample collection.
- Patients must be able to understand and willing to sign an IRB-approved informed consent document.
- Patients must have an archival fresh frozen tissue sample available for shipment that meets the criteria specified in section 5.3.
- Patients must either have 2mL of frozen whole blood available for shipment or agree to have an additional blood sample collected as described in section 5.2.
Exclusion Criteria Not Available
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