Study:
Creatine Metabolism in Humans:Effect of Creatine and Amino Acid Supplement
Rationale:
n/a
Purpose:
The goal of the present study is to quantify the rate of synthesis of creatine in healthy
controls and endurance trained subjects. In addition, the effect of oral creatine supplement
for seven days on creatine kinetics will be examined.
Ten healthy controls (age 20-35 years) and ten endurance trained subjects will be recruited
by advertisement. Endurance trained subjects will be recruited from health clubs. They
will be screened for absence of any chronic disease (history, physical examination, CBC,
metabolic and liver panel, urinalysis). A DEXA measurement will be done to quantify whole
body skeletal muscle mass.
For five (5) days prior to the study, they will be placed on a creatine-free (essentially
meat-free) diet. Dietary compliance will be ensured by repeated communication with the
subject, by nurse coordinator and the CRU Nutritionist. Subject will maintain daily record
of the food intake for validation. On the last day, i.e. 24 hours prior to the tracer study,
subject will collect the 24 hours urine sample and bring it to the CRU on the day of the
study.
Study Status: Recruiting
Recruiting:
Satish Kalhan, MD 216-444-4225 kalhans2@ccf.org
| Condition |
Intervention |
Phase |
|
Creatine Synthesis in Healthy Subjects |
Dietary Supplement: Creatine and Amino Acid supplement |
N/A |
Verified by
The Cleveland Clinic
November, 2012
Sponsored by: The Cleveland Clinic
Information provided by: The Cleveland Clinic
ClinicalTrials.gov identifier: NCT01725503
Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Cleveland Clinic
Cleveland, Ohio 44195
United States
Satish Kalhan, MD., Principal Investigator