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A Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma


A Phase 2 Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL)




This is an open-label, multicenter, phase 2 clinical trial to evaluate the efficacy and safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of brentuximab vedotin in combination with rituximab in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of CD30 expression and response in DLBCL (Part C).

Study Status: Recruiting

Elizabeth Gazdick 216-445-8907

Condition Intervention Phase
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Non-Hodgkin
Lymphoma, T-Cell
Drug: brentuximab vedotin
Drug: rituximab
Phase 2

Verified by Seattle Genetics, Inc. December, 2013

Sponsored by: Seattle Genetics, Inc.
Information provided by: Seattle Genetics, Inc. identifier: NCT01421667

Study Type: Interventional

Study Design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic, The
Cleveland, Ohio 44195
United States

Dana Kennedy, PharmD., Study Director

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