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Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases


A Phase II Trial of Hippocampal Avoidance During Whole Brain Radiotherapy for Brain Metastases


Radiation therapy uses high energy x-rays to kill tumor cells.


This phase II trial is studying how well avoiding the hippocampus during whole-brain radiation therapy works in treating patients with brain metastases.

Study Status: Active, not recruiting


Condition Intervention Phase
Cognitive/Functional Effects
Metastatic Cancer
Unspecified Adult Solid Tumor, Protocol Specific
Other: laboratory biomarker analysis
Other: questionnaire administration
Procedure: cognitive assessment
Procedure: quality-of-life assessment
Radiation: intensity-modulated radiation therapy
Radiation: whole-brain radiation therapy
Phase 2

Verified by Radiation Therapy Oncology Group January, 2014

Sponsored by: Radiation Therapy Oncology Group
Information provided by: Radiation Therapy Oncology Group identifier: NCT01227954

Study Type: Interventional

Study Design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States

Minesh P. Mehta, MD., Principal Investigator

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