Study:
Randomized Phase III Study of Maintenance Therapy With Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC
Rationale:
Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the
growth of non-small cell lung cancer by blocking blood flow to the tumor. Pemetrexed
disodium may stop the growth of tumor cells by blocking some enzymes needed for cell growth.
It is not yet known whether giving bevacizumab or pemetrexed disodium alone or in
combination is more effective in treating non-squamous non-small cell lung cancer.
Purpose:
This randomized phase III trial is studying bevacizumab and pemetrexed disodium
alone or in combination after induction therapy to see how well they work in treating
patients with advanced non-squamous non-small cell lung cancer.
Study Status: Recruiting
Recruiting:
Clinical Trials Office - Cleveland Clinic Florida - Weston 954-659-5705
Anjali S. Advani 216-839-3200
Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente 866-223-8100
Clinical Trials Office - Cleveland Clinic Cancer Center at Fai 216-476-9362
Anjali S. Advani 216-524-7979
Anjali S. Advani 440-878-2500
Clinical Trials Office - Cleveland Clinic - Wooster 800-862-7798
| Condition |
Intervention |
Phase |
|
Lung Cancer |
Biological: bevacizumab
Drug: pemetrexed disodium |
Phase 3 |
Verified by
Eastern Cooperative Oncology Group
December, 2012
Sponsored by: Eastern Cooperative Oncology Group
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov identifier: NCT01107626
Study Type: Interventional
Study Design: Allocation: Randomized, Masking: Open Label, Primary Purpose: Treatment
Cleveland Clinic Florida - Weston
Weston, Florida 33331
United States
Cleveland Clinic Beachwood Family Health and Surgery Center
Beachwood, Ohio 44122
United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio 44111
United States
Cleveland Clinic Cancer Center
Independence, Ohio 44131
United States
Cleveland Clinic Foundation - Strongsville
Strongsville, Ohio 44136
United States
Cleveland Clinic - Wooster
Wooster, Ohio 44691
United States
Suresh Ramalingam, MD., Principal Investigator