Study:
Treatment of Children With All Stages of Hepatoblastoma
Rationale:
Drugs used in chemotherapy work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Giving more than one
drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether
surgery is more effective with or without chemotherapy or which chemotherapy regimen may be
more effective in treating young patients with liver cancer.
Purpose:
This phase III trial is studying the side effects of giving doxorubicin
hydrochloride together with combination chemotherapy and to compare different chemotherapy
regimens to see how well they work in treating young patients with newly diagnosed liver
cancer.
Study Status: Recruiting
Recruiting:
Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente 866-223-8100
| Condition |
Intervention |
Phase |
|
Liver Cancer |
Drug: cisplatin
Drug: doxorubicin hydrochloride
Drug: fluorouracil
Drug: irinotecan hydrochloride
Drug: vincristine sulfate
Procedure: liver transplantation
Procedure: therapeutic conventional surgery |
Phase 3 |
Verified by
Children`s Oncology Group
November, 2012
Sponsored by: Children`s Oncology Group
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov identifier: NCT00980460
Study Type: Interventional
Study Design: Masking: Open Label, Primary Purpose: Treatment
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio 44195
United States
Howard M. Katzenstein, MD., Study Chair